Lower cumulative live birth rates in cured endometrial tuberculosis patients after one ART cycle including all subsequent frozen-thaw cycles: A matched-pair study

Lin, Mingmei; Yang, Wenling; Du, Xiaoguo; Song, Xueling; Qiao, Jie; Li, Rong

doi:10.1016/j.eurox.2019.100104

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…According to a report by the World Health Organization (WHO) in 2020, the global TB incidence rate is ~130 per 100,000 ( 1 ). TB may affect the reproductive ability of women and is a common cause of infertility due to blockage of the fallopian tubes or through the involvement of endometrium or ovarian functions ( 3 , 4 ). Early identification of active TB cases and active anti-TB treatment are essential.…”

Section: Introductionmentioning

confidence: 99%

Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study

et al. 2021

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Introduction: Tuberculosis (TB) is a major infectious disease that seriously endangers human health and female reproduction. In our previous study, 10.4% of infertile patients preparing for In vitro fertilization and embryo transfer (IVF-ET) had prior pulmonary TB (PTB) as detected on chest X-ray (CXR) screening. Among them, 81.8% did not receive anti-TB treatment. It remains unclear whether infertile women with untreated prior PTB have latent TB infection (LTBI) and whether LTBI affects IVF-ET outcomes. In this study, we aim to analyze the relationship between LTBI and pregnancy outcomes following IVF-ET in patients with untreated prior PTB.Methods and Analysis: We designed a prospective cohort study of 1,200 infertile women with CXR findings suggestive of old-healed untreated TB, who are preparing for IVF-ET. Patients with a history of active TB and anti-TB treatment will be excluded. Interferon-gamma release assay (IGRA) will be used in patients with CXR findings suggestive of old-healed untreated TB to construct a cohort of IGRA-positive and IGRA-negative patients. Participants will undergo IVF-ET. General information, including age, body mass index, infertility causes, and controlled ovarian hyperstimulation protocol, will be recorded. Participants will be followed up during pregnancy. The primary outcome is live birth. Secondary outcomes include the numbers of retrieved oocytes, high-quality embryo rate, clinical pregnancy, number of active TB cases during pregnancy, and miscarriage.Ethics and Dissemination: The study was approved by the Ethics Committee of Peking University Third Hospital [approval number (2020)218-01; approval date: June 19, 2020]. The research results will be disseminated through scientific/medical conferences and published in academic journals.Trial Registration:ClinicalTrials.gov; identifier: NCT04443283.

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Section: Introductionmentioning

confidence: 99%

Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study

et al. 2021

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“…Therefore, some cases of spontaneous abortion may have been induced by the reactivation of tubal TB. Lin et al reported that cured endometrial TB was also associated with a low live birth rate ( 23 ). We reviewed the medical records of all IVF-TB cases (including ultrasound, magnetic resonance imaging, computed tomography, and gynecologic examination report findings) to assess the possibility of pre-existed endometrial TB, but the evidence was quite limited.…”

Section: Discussionmentioning

confidence: 99%

Association of in vitro fertilization with maternal and perinatal outcomes among pregnant women with active tuberculosis: A retrospective hospital-based cohort study

Xia

Mijiti

Liu

et al. 2022

Front. Public Health

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BackgroundStudy on effect of fertilization methods on maternal and perinatal outcomes with respect to TB during pregnancy was scarce. This study aimed to analyze maternal and perinatal outcomes in active TB cases after in vitro fertilization (IVF) treatment vs. normal pregnancy.MethodsClinical data of 80 pregnant women with active TB hospitalized at Shanghai Public Health Clinical Center between June 1st, 2014 and November 30th, 2020 were extracted and retrospectively analyzed. History of receiving IVF was recorded at admission and its association with maternal and perinatal outcomes were assessed using multivariable logistic regression models with adjustment for potential confounders.ResultsOf the 80 pregnant women with active TB, 28 (35.0%) received IVF treatment and 52 (65.0%) did not receive IVF treatment. After adjusting for potential confounders, receiving IVF was associated with worse maternal and perinatal outcomes, including maternal criticality (21.4 vs. 2.0%, adjusted OR = 28.3, P = 0.015), miliary TB (89.3 vs. 13.5%, adjusted OR = 75.4, P < 0.001), TB meningitis (32.1 vs. 7.7%, adjusted OR = 6.2, P = 0.010), and perinatal mortality (64.3 vs. 28.8%, adjusted OR = 9.8, P = 0.001).ConclusionThe additional risk of TB to women receiving IVF treatment is a public health challenge specific to countries with a high tuberculosis burden. Increased awareness of latent tuberculosis infection in women receiving IVF treatment is needed.

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“…(p value -0.434)This can be correlated with the study by Bapna et al and Shende P etal.where the pregnancy rate was 19.1% per transfer, live birth was about 24.4% and 16% respectively. [39,40,41] Risk of ETP increases by 7-to 13-fold after one episode of tubal ectopic pregnancy. A patient with prior pregnancy has a 50%-80% chance of having a subsequent intrauterine pregnancy (IUP) and a 10%-25% risk of a future tubal pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Latent Genital Tuberculosis – A Causative Factor for Ectopic Pregnancy- A Retrospective Analysis

Chatterjee¹

2020

JCRR

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Background: Ectopic tubal pregnancy (ETP) is a dreadful situation for both the patient and the doctor. Prevalence of ETP is increasing because of availability of convenient and modern modalities for the diagnosis of ectopic pregnancy. Patients are aware of the condition and many lives can be saved when diagnosed and managed at an early stage; still almost 10% of maternal deaths are due to ETP. The etiology of ETP remains unknown in almost half of the cases and hence the risk of recurrence remains high. The present study has been conducted to screen patients with history of tubal ectopic pregnancyand to determine the role of tubercular infestation of the eutopicendometrium as an important etiological factor in ‘unexplained’ ectopic. Results: This retrospective analysis was conducted at Calcutta Fertility Mission in Kolkata, India, from January 2010 to December 2018. Of 282 patients with history of ETP,who were selected, 109 were in Group A, 72 of them in Group B and 101 in Group C. Tubercular infestation of the endometrium (DNA-PCR positive) was found in all (109) patients in Group A, and others in Group B and C had previous history of pelvic surgery or endometriosis, pelvic infection or unexplained infertility associated with tubercular infestation of the endometrium. In our study latent genital tuberculosis has been proved to be a statistically significant factor for ETP. (p value - <0.001) Moreover other factors like tubal surgeries (p value - <0.001) or correction of minor tubal defects (p value – 0.024); endometriosis (p value- <0.001) and pelvic inflammatory disease (p value -<0.001), have shown statistical significance in causing ectopic pregnancy. Clinical pregnancy rate (p value -0.002) and live birth rate (p value-<0.001) has been proved to be statistically significant after treatment of ETP. Conclusion: Along with the documented causes of ETP tubercular infestation of the endometrium should be considered as an important etiology for ectopic pregnancy and should be screened on a routine basis for early intervention and treatment.

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Lower cumulative live birth rates in cured endometrial tuberculosis patients after one ART cycle including all subsequent frozen-thaw cycles: A matched-pair study

Cited by 6 publications

References 16 publications

Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study

Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study

Association of in vitro fertilization with maternal and perinatal outcomes among pregnant women with active tuberculosis: A retrospective hospital-based cohort study

Latent Genital Tuberculosis – A Causative Factor for Ectopic Pregnancy- A Retrospective Analysis

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