Lower apoptosis rate and higher CD69 expression in neutrophils from atopic individuals

Nopp, Anna; Stridh, Hélène; Grönneberg, R.; Lundahl, Joachim

doi:10.1007/pl00012424

Cited by 3 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wedi and co-workers [43] reported that prolonged peripheral blood eosinophil survival is a feature of inhalant allergy and extrinsic and intrinsic atopic dermatitis as compared with nonatopic subjects. Similarly, a more recent study suggested that eosinophils from atopic individuals display significantly higher viability as compared with non-atopic individuals in the absence of and in the presence of GM-CSF [44]. Furthermore, in mild asthmatic patients demonstrating a late asthmatic response, allergen challenge prolongs the survival of peripheral blood eosinophils [45].…”

Section: Delayed Eosinophil Apoptosis In Asthmamentioning

confidence: 96%

Pharmacological Regulation of Human Eosinophil Apoptosis

Kankaanranta

Moilanen²,

Zhang

2005

CDTIA

View full text Add to dashboard Cite

Eosinophilic inflammation of the airways is a key characteristic of asthma. The balance between eosinophil recruitment into the lung and their removal from the lungs determines the number of eosinophils in the airways. Apoptosis or programmed cell death is of importance in the removal of eosinophils from the lungs. In asthma, eosinophil apoptosis is delayed. Glucocorticoids enhance eosinophil apoptosis, whereas beta(2)-agonists may delay apoptosis in eosinophils. Detailed knowledge on the mechanisms that regulate this process gives an opportunity to develop specific asthma therapies targeting the eosinophil. This review aims to focus on the signalling leading to or preventing apoptosis in human eosinophils as well as reviews the current evidence on the regulation of eosinophil apoptosis and/or survival in allergic diseases.

show abstract

Section: Delayed Eosinophil Apoptosis In Asthmamentioning

confidence: 96%

Pharmacological Regulation of Human Eosinophil Apoptosis

Kankaanranta

Moilanen²,

Zhang

2005

CDTIA

View full text Add to dashboard Cite

show abstract

“…It is noteworthy that some molecular regulators of neutrophil apoptosis, such as CD69, SAA, and SHP, are practically not detectable in healthy people, but their count increases dramatically in some diseases. At the same time, increased CD69 and SAA expression is associated with suppression of apoptosis [ 91 , 96 , 97 ], while SHP, on the contrary, with its activation [ 76 , 46 ] ( Table 1 ). Local tissue lesions associated with acute circulatory disorders or trauma is the cause of the development of sterile inflammation accompanied by DAMP release and neutrophilic infiltration.…”

Section: Apoptosis Disturbances In Pathologymentioning

confidence: 99%