Lower AMP-activated protein kinase level is associated with the vulnerability of coronary atherosclerotic plaques by attenuating the expression of monocyte autophagy

Abstract

Therefore, our work is novel in showing that AMPK of PBMs may decrease plaque vulnerability and subsequent plaque rupture through activation of autophagy.

Ginsenoside Rb1 Enhances Atherosclerotic Plaque Stability by Improving Autophagy and Lipid Metabolism in Macrophage Foam Cells

“…AMPK is an evolutionarily conserved sensor of cellular energy receptor and plays a critical role in glucose and lipid metabolism, as well as the induction of autophagy ( Kahn et al, 2005 ; Zhang et al, 2016 ). Our previous studies have shown that a lower AMPK activation level was associated with coronary atherosclerotic plaque vulnerability by attenuating autophagy in peripheral blood monocytes ( Cheng et al, 2015 ). In addition, Rb1 has also been shown to be able to promote AMPK phosphorylation in rats ( Shen et al, 2013 , 2015 ).…”

Ogg1 -Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis

“…The expression of AMPKα is diminished during atherogenesis, which leads to decreased autophagy and paradoxical upregulation of SREBP-1c and SREBP-2, as well as further progression of atherosclerosis 79, 80 . Restoring AMPKα expression protects from atherogenesis 81, 82 .…”

Resveratrol protects neuronal cells from isoflurane‑induced inflammation and oxidative stress‑associated death by attenuating apoptosis via Akt/p38 MAPK signaling

“…It is therefore widely employed in surgical anesthesia and operations of diagnosis and treatment, such as minor surgery, gastrointestinal endoscopy and interventional therapy (4). Animal studies have demonstrated that isoflurane and inhalation anesthetics induce apoptosis of neurocytes in neonatal animals and further damage cognitive function (3).…”