Low zinc status: a new risk factor for pneumonia in the elderly?

Barnett, Junaidah B.; Hamer, Davidson H.; Meydani, Simin Nikbin

doi:10.1111/j.1753-4887.2009.00253.x

Cited by 120 publications

(105 citation statements)

References 106 publications

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“…Previous findings linked zinc deficiency to immune cell dysfunction, and to increased susceptibility to airway infections (45,73). In murine polymicrobial sepsis (67), zinc deficiency produced increased inflammation similar to that evoked here by MV.…”

Section: Discussionmentioning

confidence: 61%

“…Zinc is an essential micronutrient (34,(40)(41)(42), and its tissue and plasma levels are influenced by dietary intake (38,42). While severe zinc deficiency is rare in the developed world, moderate zinc deficiency is widespread, concentrated in elderly populations (42)(43)(44)(45), and can be exacerbated in critically ill patients (33,(46)(47)(48)(49). We demonstrate that both genetic MT deficiency and dietary zinc deficiency potentiate lung injury in mechanically ventilated mice, consistent with an essential role for the zinc/MT system in protecting the lung from injurious stretch.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Zinc deficiency primes the lung for ventilator-induced injury

Boudreault¹,

Vera²,

Englert³

et al. 2017

JCI Insight

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Section: Discussionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Zinc deficiency primes the lung for ventilator-induced injury

Boudreault¹,

Vera²,

Englert³

et al. 2017

JCI Insight

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“…Several other studies showed that underweight and micronutrient deficiencies were associated with higher odds of respiratory infections [23–25]. …”

Section: Introductionmentioning

confidence: 99%

One-fourth of the prisoners are underweight in Northern Ethiopia: a cross-sectional study

Abera

Adane

2017

BMC Public Health

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BackgroundDespite the fact that prisoners are exposed to different health problems, prison health problems are often overlooked by researchers and no previous study has investigated nutritional problems of prisoners in Ethiopia.MethodsCross-sectional data were collected from 809 prisoners from nine major prison setups in the Tigray region of Ethiopia. A proportional stratified sampling technique was used to select the total number of participants needed from each prison site. The outcome of this study was underweight defined as body mass index (BMI) of less than 18.5 kg/m2. Multivariable binary logistic regression was performed to identify determinants of underweight at a p-value of less than 0.05.ResultsThe prevalence of underweight was 25.2% (95% CI; 22.3%- 28.3%). Khat Chewing (OR = 2.08; 95% CI = 1.17, 3.70) and longer duration of incarceration (OR = 1.07; 95% CI = 1.01, 1.14) were associated with a significantly increased risk of underweight. Additionally, previous incarceration (OR = 1.54; 95% CI = 0.99, 2.42) was a relevant determinant of underweight with a borderline significance. In contrast, family support (OR = 0.61; 95% CI = 0.43, 0.85) and farmer occupation (OR = 0.59; 95% CI = 0.36, 0.98) compared to those who were unemployed were important protective determinants significantly associated with lower risk of underweight.ConclusionIn summary, the burden of underweight was higher among prisoners in Tigray region who had respiratory tract infections. The study has enhanced our understanding of the determinants of underweight in the prison population. We strongly recommend that nutritional support, such as therapeutic feeding programs for severely or moderately underweight prisoners, and environmental health interventions of the prison setups should be urgently implemented to correct the uncovered nutritional problem and its associated factors for improving the health status of prisoners.

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“…Optimal daily level of zinc supplementation ranges from 30 to 85 mg [12,13,14]. Although it is not known whether dietary zinc intake affects intraprostatic zinc levels, our earlier studies on rats have indicated that oral administration of zinc significantly increases its concentration in the prostate, but its availability in this organ varies based on individual zinc preparations, which may be based on differences in absorption associated with zinc preparations [15].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Zinc and Selenium Supplementation Mode on Their Bioavailability in the Rat Prostate. Should Administration Be Joint or Separate?

et al. 2016

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It is thought that zinc and selenium deficiency may play a significant role in the etiology of prostate cancer. Although joint zinc and selenium supplementation is frequently applied in the prevention of prostate diseases, the bioavailability of these elements in the prostate after co-administration is still unknown. The study examines the effect of subchronic supplementation of zinc gluconate and selenium compounds (sodium selenite or selenomethionine), administered together or separately, on their bioavailability in the prostate, as well as the induction of metallothionein-like proteins (MTs) bound to zinc in the prostate and liver. Zinc concentration in the dorso-lateral lobe of the prostate was significantly elevated already after the first month of supplementation of zinc alone. In the supplementation period, the MTs level increased together with zinc concentration. In contrast, the ventral lobe of the prostate did not demonstrate significantly higher levels of zinc until after three months of supplementation, despite the MTs induction noted after one-month supplementation. Increased selenium levels in the dorsolateral lobe were observed throughout the administration and post-administration periods, regardless of the selenium compound used or whether zinc was co-administered. The results of our studies suggested for the first time that these elements should not be administered jointly in supplementation.

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Low zinc status: a new risk factor for pneumonia in the elderly?

Cited by 120 publications

References 106 publications

Zinc deficiency primes the lung for ventilator-induced injury

Zinc deficiency primes the lung for ventilator-induced injury

One-fourth of the prisoners are underweight in Northern Ethiopia: a cross-sectional study

The Effect of Zinc and Selenium Supplementation Mode on Their Bioavailability in the Rat Prostate. Should Administration Be Joint or Separate?

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