Low Wall Shear Stress and High Intra-aneurysmal Pressure are Associated with Ruptured Status of Vertebral Artery Dissecting Aneurysms

Wei, Heng; Yao, Kathy; Tian, Qi; Han, Shoumeng; Gao, Weiwei; Han, Wenrui; Liu, Sheng; Wang, Guijun; Chen, Qianxue; Li, Mingchang

doi:10.1007/s00270-022-03353-2

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…There are two views on WSS research at present. One is that low WSS causes endothelial cell dysfunction, affects the endothelial cell secretion mode, leads to increased production of vasoconstriction and in ammatory substances, decreases vasodilators and antioxidants, and increases the susceptibility of vessels to rupture [7]. The other is that high WSS often causes chronic damage to endothelial cells in vessel walls, resulting in decreased endothelial cells, increased permeability, elastic layer degeneration, and medial layer thinning of arterial vessel walls, which are also the main factors involved in aneurysm formation and growth [8][9].…”

Section: Discussionmentioning

confidence: 99%

Correlation analysis of vertebral artery hemodynamic differences and clinical symptoms due to craniocervical junction abnormalities: based on computational fluid dynamics

Zhang,

Ai,

et al. 2024

Preprint

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Background and purpose Patients with craniocervical junction abnormalities (CJA) often exhibit vertebral artery (VA) abnormalities, and identifying these abnormalities can be beneficial for assessing patient symptoms and developing treatment plans. Material and Methods Sixty patients with CJA were admitted to our department from January 2018 to June 2022. Sixty healthy people were selected to undergo combined head and neck CTA, and the CTA images were imported into CFD-related software. The results were used to visualize and derive the lumen diameter (D), peak systolic velocity (PSV), mean blood flow velocity (MV), wall pressure (WP), wall shear stress (WSS) and other related data of vertebral arteries in different segments, and cross-sectional planes of the vertebral arteries at different segments were constructed to calculate the quantity of blood flow (Q) and the ratio of each index in each segment. The dizziness handicap inventory (DHI) was chosen to assess patient dizziness symptoms, and a multinomial logistic model was used to analyze the correlation between differences in vertebral artery hemodynamics due to patients with CJA and clinical symptoms such as dizziness. Results Compared with those in the control group, the mean DV3−V4, D\(\frac{\text{V}3-\text{V}4}{\text{V}1-\text{V}2}\)、QV3−V4、Q\(\frac{\text{V}3-\text{V}4}{\text{V}1-\text{V}2}\) of VA in the CJA group were significantly lower; the PSVV3−V4, PSV\(\frac{\text{V}3-\text{V}4}{\text{V}1-\text{V}2}\)、MVV1−V2、MVV3−V4、MV\(\frac{\text{V}3-\text{V}4}{\text{V}1-\text{V}2}\), WP and WSS in the CJA group were significantly greater; and the difference was statistically significant (P<0.05). According to the multinomial logistic regression analysis, for every 0.02 unit decrease in QV3−V4, the risk of increasing the DHI score to a higher grade increased by 40.49% compared with the original basis. Conclusions The V3-V4 segment of the vertebral artery in patients with CJA differs from that in the normal population in terms of hemodynamics, such as D, V, WP, and WSS, especially Q, and these differences lead to the occurrence of clinical symptoms such as dizziness and vertigo. The quantity of blood flow is negatively correlated with DHI, and age is positively correlated with DHI.

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Section: Discussionmentioning

confidence: 99%

Correlation analysis of vertebral artery hemodynamic differences and clinical symptoms due to craniocervical junction abnormalities: based on computational fluid dynamics

Zhang,

Ai,

et al. 2024

Preprint

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“…However, more recent research has determined that it is, in fact, low WSS values which are the primary indicators of future CVD [11]. Low WSS values have also consistently been associated with increased risk of saccular aneurysm rupture [12].…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of a Multifrequency Ultrafast Doppler Spectral Analysis (MFUDSA) Algorithm for Wall Shear Stress Measurement: A Simulation and In Vitro Study

et al. 2023

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Cardiovascular pathology is the leading cause of death and disability in the Western world, and current diagnostic testing usually evaluates the anatomy of the vessel to determine if the vessel contains blockages and plaques. However, there is a growing school of thought that other measures, such as wall shear stress, provide more useful information for earlier diagnosis and prediction of atherosclerotic related disease compared to pulsed-wave Doppler ultrasound, magnetic resonance angiography, or computed tomography angiography. A novel algorithm for quantifying wall shear stress (WSS) in atherosclerotic plaque using diagnostic ultrasound imaging, called Multifrequency ultrafast Doppler spectral analysis (MFUDSA), is presented. The development of this algorithm is presented, in addition to its optimisation using simulation studies and in-vitro experiments with flow phantoms approximating the early stages of cardiovascular disease. The presented algorithm is compared with commonly used WSS assessment methods, such as standard PW Doppler, Ultrafast Doppler, and Parabolic Doppler, as well as plane-wave Doppler. Compared to an equivalent processing architecture with one-dimensional Fourier analysis, the MFUDSA algorithm provided an increase in signal-to-noise ratio (SNR) by a factor of 4–8 and an increase in velocity resolution by a factor of 1.10–1.35. The results indicated that MFUDSA outperformed the others, with significant differences detected between the typical WSS values of moderate disease progression (p = 0.003) and severe disease progression (p = 0.001). The algorithm demonstrated an improved performance for the assessment of WSS and has potential to provide an earlier diagnosis of cardiovascular disease than current techniques allow.

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Low shear stress induces macrophage infiltration and aggravates aneurysm wall inflammation via CCL7/CCR1/TAK1/ NF-κB axis

Wei,

Wang,

Tian

et al. 2024

Cellular Signalling

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Low Wall Shear Stress and High Intra-aneurysmal Pressure are Associated with Ruptured Status of Vertebral Artery Dissecting Aneurysms

Cited by 4 publications

References 40 publications

Correlation analysis of vertebral artery hemodynamic differences and clinical symptoms due to craniocervical junction abnormalities: based on computational fluid dynamics

Correlation analysis of vertebral artery hemodynamic differences and clinical symptoms due to craniocervical junction abnormalities: based on computational fluid dynamics

Development and Evaluation of a Multifrequency Ultrafast Doppler Spectral Analysis (MFUDSA) Algorithm for Wall Shear Stress Measurement: A Simulation and In Vitro Study

Low shear stress induces macrophage infiltration and aggravates aneurysm wall inflammation via CCL7/CCR1/TAK1/ NF-κB axis

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