Low- vs high-dose aspirin. Effects on platelet function in hyperlipoproteinemic and normal subjects

Zucker, Marjorie L.; Trowbridge, Cynthia A.; Woodroof, Janet; Chernoff, S B; Reynoso, Lance; Dujovne, Carlos A.

doi:10.1001/archinte.146.5.921

Cited by 10 publications

(5 citation statements)

References 24 publications

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“…In a separate study, McLeod et al used doses ranging from 50 to 3900 mg of aspirin and monitored platelet function, bleeding time, and concluded that maximum dysfunction was obtained with daily doses of about 100 mg and no further changes were observed in these studies with higher doses [17]. Several workers have demonstrated the efficacy of low-dose oral aspirin in preventing platelet thromboxane production [2–4, 17, 43]. Indeed one of these studies has demonstrated beneficial effect of a dermal aspirin preparation on selective inhibition of platelet prostaglandin synthase, sparing the prostacyclin biosynthesis [31].…”

Section: Studies On the Use Of Aspirin As An Inhibitor Of Cyclooxymentioning

confidence: 99%

“…However, earlier studies did not report prevalence of any aspirin resistance. Zucker et al evaluated the effect of low-dose aspirin (0.45 mg/kg/day) and a high dose (900 mg/day) in type 11 hyperlipoproteinemic subjects [43]. They found that low-dose aspirin effectively inhibited platelet function in these patients.…”

Section: Clinical Studies On the Use Of Aspirinmentioning

confidence: 99%

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Aspirin Prophylaxis for the Prevention of Thrombosis: Expectations and Limitations

Rao

Fareed

2012

Thrombosis

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Platelets play a very important role in the pathogenesis of acute vascular events leading to thrombosis of the coronary and cerebral arteries. Blockage of these arteries leading to regional ischemia of heart and brain tissues precipitate heart attacks and stroke. Acetyl salicylic acid (Aspirin) has been the drug of choice for over half a century for the primary and secondary prophylaxis of thrombotic events. In spite of its extensive use as an antiplatelet drug for the prevention of vascular thrombosis, there is considerable concern about the degree of protection it offers, to patients under aspirin therapy. In this paper, we explain the phenomenon of aspirin resistance, discuss the limitations of aspirin therapy, and suggest methods to monitor “at-risk” individuals. Ability to monitor and determine at risk patients will provide opportunities for the clinicians to customize antiplatelet therapies.

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Section: Studies On the Use Of Aspirin As An Inhibitor Of Cyclooxymentioning

confidence: 99%

Section: Clinical Studies On the Use Of Aspirinmentioning

confidence: 99%

Aspirin Prophylaxis for the Prevention of Thrombosis: Expectations and Limitations

Rao

Fareed

2012

Thrombosis

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“…24,[27][28][29][30][31][32][33][34][35] This finding, however has not been confirmed by other studies. [36][37][38][39][40] Several reasons may explain this discrepancy. Among these are the criteria for patient selection.…”

Section: Studies In Human Hypercholesterolemia Platelet Aggregation Smentioning

confidence: 99%

Hypercholesterolemia and Platelets

Tremoli¹,

Colli²,

Maderna³

et al. 1993

Semin Thromb Hemost

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“…Infections such as dengue virus, chickenpox, rubella and bacteria effect the circulating platelet number in the blood [132]. Antiplatelet drugs like aspirin impairs platelet aggregation therefore over dosage of aspirin can cause hemorrhage [133]. Acquired platelet disorders are analyzed by platelet count and their aggregation properties.…”

Section: Acquired Disorders Of Platelet Functionmentioning

confidence: 99%

Understanding the Clotting Cascade, Regulators, and Clinical Modulators of Coagulation

Pilli¹

2018

Hematology - Latest Research and Clinical Advances

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The circulatory system plays a vital role in the survival of an organism by supplying it with essential nutrients, signaling molecules and eliminating the waste or toxic products from the body. This flow is tightly regulated by various factors, procoagulants support the formation of hemostatic plugs to prevent the leakage or blood loss and anticoagulants prevent the formation of unwanted clots. Disruption or dysregulation of procoagulants and anticoagulants lead to clinical complexities. In this chapter defects in the coagulation system, hereditary, acquired coagulation disorders, their diagnosis and recent clinical modulators of the coagulation system are discussed.

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Low- vs high-dose aspirin. Effects on platelet function in hyperlipoproteinemic and normal subjects

Cited by 10 publications

References 24 publications

Aspirin Prophylaxis for the Prevention of Thrombosis: Expectations and Limitations

Aspirin Prophylaxis for the Prevention of Thrombosis: Expectations and Limitations

Hypercholesterolemia and Platelets

Understanding the Clotting Cascade, Regulators, and Clinical Modulators of Coagulation

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