Low-volume oral colonoscopy bowel preparation: Sodium phosphate and magnesium citrate

Berkelhammer, Charles; Ekambaram, Anita; Silva, Rogelia G.

doi:10.1067/mge.2002.125361

Cited by 76 publications

(53 citation statements)

References 24 publications

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“…On the basis of data from previous studies [20][21][22] , a sample size of 200 patients was estimated to give an 80% power at a two-sided alpha of 0.05% to detect a 15% difference in the Ottawa bowel preparation quality scale. Bowel preparation scores measured by the Ottawa Scale were compared between the morning and splitdose groups using the Mann-Whitney U test.…”

Section: Discussionmentioning

confidence: 99%

“…Prior studies have demonstrated that split dosing not only to improves patient acceptability, but also cleans the colon better [8] . Of 13 prospective, randomized studies done previously, 12 showed superior cleansing when whole or part of the bowel preparation was given in the morning of the scheduled colonoscopy [9][10][11][12][13][14][15][16][17][18][19][20][21] . However colonoscopies are often scheduled in the afternoon, and split dosing may not leave a clean colon by afternoon.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of split-dosingvsnon-split (morning) dosing regimen for assessment of quality of bowel preparation for colonoscopy

Shah

Desai

Samant

et al. 2014

WJGE

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AIM: To compare (using the Ottawa Bowel PreparationScale) the efficacy of split-dose vs morning administration of polyethylene glycol solution for colon cleansing in patients undergoing colonoscopy, and to assess the optimal preparation-to-colonoscopy interval. METHODS:Single-centre, prospective, randomized, investigator-blind stud in an academic tertiarycare centre. Two hundred patients requiring elective colonoscopy were assigned to receive one of the two preparation regimens (split vs morning) prior to colonoscopy. Main outcome measurements were bowel preparation quality and patient tolerability. RESULTS:Split-dose regimen resulted in better bowel preparation compared to morning regimen [Ottawa score mean 5.52 (SD 1.23) vs 6.02 (1.34); P = 0.017].On subgroup analysis, for afternoon procedures, both the preparations were equally effective (P = 0.756). There was no difference in tolerability and compliance between the two regimens. CONCLUSION:Overall, previous evening -same morning split-dosing regimen results in better bowel cleansing for colonoscopy compared to morning preparation. For afternoon procedures, both schedules are equally effective; morning preparation may be more convenient to the patient. Key words: Bowel preparation; Colonoscopy; Morning preparation; Split dose preparation; Preparation to colonoscopy interval Core tip: Split bowel reparation compared to single dose morning preparation resulted in a better bowel cleansing using the Ottawa Bowel Preparation Scale. The average score (± SD) using the Ottawa Scale was 6.02 ± 1.34 when morning preparation was given and 5.52 ± 1.23 when split preparation was given (P = 0.017). However, there was no statistical difference in the mean Ottawa score when the procedures were done in the afternoon with either the morning or the split preparation (6.09 vs 5.94, P = 0.756). Hence, AM only dosing is as effective as split dosing for patients scheduled for a colonoscopy in the afternoon.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of split-dosingvsnon-split (morning) dosing regimen for assessment of quality of bowel preparation for colonoscopy

Shah

Desai

Samant

et al. 2014

WJGE

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“…Bisacodyl causes histologic and macroscopic changes in the colonic mucosa. Phosphate preparation has been noted to induce rectosigmoid aphthous ulcerations, and in one study, aphthous ulcers occurred in 5.5% of patients receiving sodium phosphate preparation [50].…”

Section: Histologymentioning

confidence: 99%

Bowel preparation for gastrointestinal procedures

Brown

DiPalma

2004

Curr Gastroenterol Rep

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Adequate colonic cleansing is essential for accurate and safe colonic procedures. Common preparations for cleansing include diet in combination with a cathartic agent, gut lavage, and phosphate preparations. The diet used with a cathartic consists of clear liquids or is designed to leave a minimal colonic fecal residue with laxatives. Gut lavage solutions wash out the colon in a safe and effective manner. Phosphate preparations offer an attractive alternative due to smaller volumes required for ingestion; however, electrolyte disturbances can occur. This review discusses the development and clinical experience with various colon cleansing regimens and efforts to improve the tolerability and safety of preparation for colonoscopy, virtual colonoscopy, colon surgery, barium enema, and flexible sigmoidoscopy.

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“…However, poor tolerance and adverse effect were often found in the bowel preparation of colonoscopy for elderly patients and those with constipation, since they are often required to drink larger volumes of lavage solution prior to the bowel cleansing procedure. Both polyethylene glycol (PEG) electrolyte solution and magnesium citrate (MGC) solution have been widely used in Japan as lavage solutions for bowel cleansing [1,2,3,4]. About 2,000 ml of these solutions are usually required for adequate bowel preparation.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Prokinetic Agents in Improving Bowel Preparation for Colonoscopy

Mishima

Amano²,

Okita³

et al. 2008

Digestion

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Background and Aim: Colonoscopy plays an important role in the diagnosis and treatment of gastrointestinal illness in both Western countries and Japan. However, preparative bowel cleansing for colonoscopy is frequently troublesome for elderly and/or constipated patients, since they must drink larger volumes of lavage solution for adequate cleansing. We investigated the use of prokinetic agents for improving the efficacy and tolerability of bowel cleansing prior to colonoscopy. Methods: 613 patients were divided into two groups according to oral lavage solution used (polyethylene glycol or magnesium citrate), and were further randomized to receive either vehicle (100 ml water) alone, vehicle with 5 mg mosapride citrate, or vehicle with 50 mg itopride hydrochloride 30 min before administration of lavage solution. Experimental parameters included bowel cleansing quality, times to first defecation and completion of bowel cleansing, and incidence of uncomfortable abdominal symptoms during colonoscopy preparation. Results: Administration of mosapride citrate or itopride hydrochloride prior to oral lavage solution did not significantly improve bowel cleansing quality. However, statistically significantly fewer uncomfortable abdominal symptoms were found in patients who received mosapride citrate or itopride hydrochloride versus vehicle alone. Conclusion: Prokinetic agents effectively decreased the incidence of uncomfortable abdominal symptoms experienced during colonoscopy preparation.

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Low-volume oral colonoscopy bowel preparation: Sodium phosphate and magnesium citrate

Cited by 76 publications

References 24 publications

Comparison of split-dosingvsnon-split (morning) dosing regimen for assessment of quality of bowel preparation for colonoscopy

Comparison of split-dosingvsnon-split (morning) dosing regimen for assessment of quality of bowel preparation for colonoscopy

Bowel preparation for gastrointestinal procedures

Efficacy of Prokinetic Agents in Improving Bowel Preparation for Colonoscopy

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