Low Vitamin D Status Among Obese Adolescents: Prevalence and Response to Treatment

Harel, Zeev; Flanagan, Patricia; Forcier, Michelle; Harel, Dalia

doi:10.1016/j.jadohealth.2011.01.011

Cited by 83 publications

(77 citation statements)

References 35 publications

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“…The lower serum 25(OH)D levels in overweight individuals has been reported previously in the scientific literature (8,9,35) . It is believed that low serum vitamin D levels in the obese are not just a consequence of reduced sun exposure.…”

Section: Discussionsupporting

confidence: 65%

“…However, recent studies have indicated that deficiency of this vitamin may confer a risk factor for the development of endocrine and metabolic diseases (6,7) . Studies suggest that vitamin D may be involved in various processes, such as cell differentiation/proliferation and hormone secretion, as well as in the immune system and in chronic diseases such as obesity, glucose intolerance, increased blood pressure and lipid abnormalities (7)(8)(9) . Despite the scientific interest in the topic, most studies investigating the consequences of hypovitaminosis D in relation to metabolic disorders have focused their attention on adults and the elderly.…”

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confidence: 99%

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Association of vitamin D insufficiency with adiposity and metabolic disorders in Brazilian adolescents

Oliveira

Novaes

Azeredo

et al. 2013

Public Health Nutr.

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Objective: The present study aimed to evaluate the frequency of deficiency/ insufficiency of vitamin D in adolescents and its relationship to overweight and metabolic disorders. Design: Cross-sectional study. Nutritional status was assessed by BMI according to WHO recommendations. Dietary intake was evaluated using a 3 d dietary record. The biochemical evaluation comprised measurements of serum lipids, lipoproteins, glucose, insulin, calcidiol (25(OH)D) and parathyroid hormone. Insulin resistance was calculated using the homeostasis model assessment. Body composition and blood pressure were assessed. Setting: Fifteen schools (eight public and seven private) in the central city of Juiz de Fora, Brazil. Subjects: The analysis included a study population of 160 adolescents (seventyseven eutrophic and eighty-three overweight) aged 15 to 17 years. Results: Vitamin D deficiency and insufficiency was observed in 1?25 and 70?6 % of adolescents, respectively. Serum 25(OH)D levels were statistically lower in adolescents with weight excess, abdominal obesity, hypercholesterolaemia, higher levels of parathyroid hormone, insulin resistance, hyperinsulinaemia and hypertension (P , 0?05). Lower BMI and waist circumference were observed in the third (highest) tertile of vitamin D intake for all adolescents. The high prevalence of vitamin D insufficiency is primarily nutritional and reflects a low vitamin D intake. Conclusions: Our results support the negative association among serum 25(OH)D levels and vitamin D intake with non-skeletal outcomes in Brazilian adolescents. Vitamin D fortification of foods and/or the use of vitamin D supplements need to be considered to raise vitamin D intake in the adolescent population, even in a sunny country like Brazil.

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Section: Discussionsupporting

confidence: 65%

mentioning

confidence: 99%

Association of vitamin D insufficiency with adiposity and metabolic disorders in Brazilian adolescents

Oliveira

Novaes

Azeredo

et al. 2013

Public Health Nutr.

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“…Furthermore, the odds of vitamin D deficiency and insufficiency were raised significantly in the higher BMI and BF% Z-score categories, which include those with BMI and BF% values above the 85th and/or 95th percentile as compared with the Center for Disease Control and Prevention BMI charts and published body fat reference curves in children (Table 3) (27) . Vitamin D inadequacy among obese individuals of all ages including adolescents has been described by several studies (13,(31)(32)(33) . This is attributed to the decreased bioavailability of vitamin D in the obese due to sequestration in body fat stores (34) .…”

Section: Predictors Of Vitamin D Levels and Statusmentioning

confidence: 94%

Association of vitamin D with adiposity measures and other determinants in a cross-sectional study of Cypriot adolescents

Kolokotroni

Papadopoulou

Yiallouros

et al. 2014

Public Health Nutr.

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“…Furthermore, these knockout mice had higher inflammation, demyelination, and axonal injury rates [88]. Moreover, obesity has been correlated with vitamin D deficiency, a known modulator of MS [89][90][91].…”

Section: Macrophagesmentioning

confidence: 99%

Elucidating the Molecular Basis of Multiple Sclerosis and Understanding the Disease Pathophysiology

Eiman¹

2016

Immunome Res

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Multiple sclerosis (MS) is a complex, multifactorial autoimmune disorder of the central nervous system (CNS) that causes inflammation, demyelination and neurodegeneration. The increased prevalence of this disease in Arabian Gulf Countries (AGCs) has captivated the author. The following is a deliberative review of the disease with respect to its molecular basis. Briefly, it considers disease pathophysiology though the molecular composition of the cell; the genome, epigenome and mitochondrial genome; and relates these factors to environmental, etiological factors, including: vitamin D, UVR, EBV infection, smoking and obesity. All in all, this review aims to explain the reasons underlying the increasing prevalence of MS in AGCs.

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Low Vitamin D Status Among Obese Adolescents: Prevalence and Response to Treatment

Cited by 83 publications

References 35 publications

Association of vitamin D insufficiency with adiposity and metabolic disorders in Brazilian adolescents

Association of vitamin D insufficiency with adiposity and metabolic disorders in Brazilian adolescents

Association of vitamin D with adiposity measures and other determinants in a cross-sectional study of Cypriot adolescents

Elucidating the Molecular Basis of Multiple Sclerosis and Understanding the Disease Pathophysiology

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