Low vitamin D levels are not a contributing factor to higher prevalence of depressive symptoms in people with Type 2 diabetes mellitus: the Hoorn study

Westra, Sanne; Şimşek, Suat; Rutters, Femke; Krul-Poel, Yvonne H M; Stehouwer, Coen D. A.; Dekker, Joost; Pouwer, Frans

doi:10.1111/dme.13265

Cited by 8 publications

(5 citation statements)

References 18 publications

(21 reference statements)

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“…In Paper III, we found an inverse association between serum 25(OH)D3 and poor mental health at baseline, but not at follow-up on mental well-being after four years. The finding that vitamin D was associated with mental health at baseline is in line with one (140) of the two previous studies confined to populations with diabetes (140,141). We found no association between serum 25(OH)D3 and vitality at baseline, and the association first seen at follow-up disappeared after controlling for data regarding diabetes status and lifestyle factors.…”

Section: Patients With Type 2 Diabetes (Papers II and Iii)supporting

confidence: 92%

Aspects of Vitamin D Deficiency in Elderly People in Nursing Homes and in Patients with Type 2 Diabetes : with Emphasis on Mortality, Cardiovascular Morbidity and Mental Health

Samefors

2020

Linköping University Medical Dissertations

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Section: Patients With Type 2 Diabetes (Papers II and Iii)supporting

confidence: 92%

Aspects of Vitamin D Deficiency in Elderly People in Nursing Homes and in Patients with Type 2 Diabetes : with Emphasis on Mortality, Cardiovascular Morbidity and Mental Health

Samefors

2020

Linköping University Medical Dissertations

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“…We found only one retrospective study [34] published in 2019, which indicates that VDD may predict poor cognitive performance in patients with T2DM. VDD has been recently correlated with depression, although a crosssectional study [35] published in 2017 concerning elderly with T2DM concluded that VDD appeared not to be a contributing factor to higher depression scores in elderly with T2DM. Although, a cross-sectional study conducted in 2015 [36] showed that VD sufficiency is associated with higher self-reported diabetes treatment satisfaction and better diabetes-specific quality of life in elderly with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency in Elderly With Diabetes Mellitus Type 2: A Review

Papaioannou¹,

Πανταζίδου²,

Kokkalis³

et al. 2021

Cureus

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Diabetes mellitus type 2 (T2DM) is an emerging public health issue with high prevalence among older adults (>60 years old). Taking into consideration the great increase in the elderly population (approximately 7.5 billion worldwide), we can easily understand the impact of this chronic disease and its complications. On the other hand, vitamin D deficiency (VDD) is also a serious public health problem with significant impacts and multiple health effects. The correlation between DM and VDD has been suggested and established from many observational studies, reviews, and meta-analyses. The literature in PubMed and Google Scholar was searched for relevant articles published up to October 2020. The keywords used were the following: vitamin D deficiency, elderly, and diabetes mellitus type 2. Among the 556 articles retrieved, 90 full texts were eligible and only 34 studies (12 retrospective studies, two prospective cohorts, three meta-analyses, seven cross-sectional studies, nine randomized control trials (RCTs), and one observational study) met the inclusion criteria for the review. The author's name, year of publication, country, type of study, and the number of patients were reported. According to this review there is adequate evidence to support the correlation between VDD and T2DM in the elderly. The results from the RCTs are more conflicting and more studies are needed to confirm the impact of vitamin D deficiency (VD) supplementation on metabolic and lipid profile, oxidative stress, and the complications of T2DM in older patients. VDD is clearly related with severe retinopathy, diabetic peripheral neuropathy, and poor cognition performance, while there is consensus about the beneficial effect of VD on peripheral artery disease, foot ulceration prevention, and wound healing. On the other hand, there is controversy about the effect of VD supplementation on cardiovascular adverse events, endothelial function, and estimated glomerular filtration rate (eGFR). Finally, the association of VDD with fragility fractures and depression in the elderly with T2DM is currently insufficiently studied and remains controversial.

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“…Vitamin D levels were lower in the depression group than in the control group. In contrast, Westra et al 15 found no correlation between vitamin D deficiency and the risk of depression in patients with T2DM. Other studies have shown different vitamin D levels in patients with obesity experiencing depression compared with those without depression.…”

Section: Discussionmentioning

confidence: 90%

“…Patients with type 2 diabetes mellitus (T2DM) are at risk for depression, with a higher prevalence rate (11)(12)(13)(14)(15)(16)(17).6%) than the general population (3-4%). 1,2 Furthermore, 41% of patients with T2DM experience depression.…”

mentioning

confidence: 99%

Vitamin D levels and depression in type 2 diabetes mellitus patients: a cross-sectional study

Putranto,

Adhiatma,

Tarigan

et al. 2023

Med J Indones

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BACKGROUND The prevalence of type 2 diabetes mellitus (T2DM) is increasing and commonly accompanied by comorbidities, such as depression. Vitamin D levels have been associated with T2DM and depression although the mechanism is uncertain. This study aimed to compare vitamin D levels between patients with T2DM with and without depression in the Indonesian community, where such research is rare. METHODS This cross-sectional study was conducted at Cipto Mangunkusumo Hospital. The participants who met the inclusion criteria on an outpatient basis were screened for depression using the Beck Depression Inventory-II (BDI-II) questionnaire and then divided into 2 groups: patients with T2DM with (BDI-II ≥14) and without (BDI-II <14) depression. Both groups were examined for vitamin D levels using the ELISA method, and an analysis of the mean difference between both groups was performed. RESULTS Of 60 patients, 23 (38%) experienced depression. The median vitamin D levels were 21.8 ng/ml (IQR 14.9–26.6) in the depression group and 26.5 ng/ml (IQR 23.96–34.08) in the non-depression group (p = 0.001). After performing multivariate analysis with confounding variables, the adjusted OR of variables (sex, sun exposure score, and body mass index) was 1.123 (95% CI: 1.003–1.259; p = 0.045). CONCLUSIONS Vitamin D levels were significantly lower in patients with T2DM with depression. Future studies should be carried out to determine the benefits of vitamin D supplementation in patients with T2DM with depression and their pathophysiology.

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Low vitamin D levels are not a contributing factor to higher prevalence of depressive symptoms in people with Type 2 diabetes mellitus: the Hoorn study

Abstract: The study found no evidence that low vitamin D levels are a contributing factor to higher depression scores in people with Type 2 diabetes.

Cited by 8 publications

References 18 publications

Aspects of Vitamin D Deficiency in Elderly People in Nursing Homes and in Patients with Type 2 Diabetes : with Emphasis on Mortality, Cardiovascular Morbidity and Mental Health

Aspects of Vitamin D Deficiency in Elderly People in Nursing Homes and in Patients with Type 2 Diabetes : with Emphasis on Mortality, Cardiovascular Morbidity and Mental Health

Vitamin D Deficiency in Elderly With Diabetes Mellitus Type 2: A Review

Vitamin D levels and depression in type 2 diabetes mellitus patients: a cross-sectional study

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