Low versus High Density of Immobilized Anti-CD3 Influences IL-4 Regulation of T-Cell Immune Responses

Jones-Tiffany, Linda A.; Mehrotra, P T; Horohov, David W.; Siegel, Jay P.; Kozak, Robert W.

doi:10.1006/cimm.1993.1081

Cited by 3 publications

(1 citation statement)

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“…[17,18] Activation of T cells is a central process for the immune response and immunotherapy. [19] Anti-CD3 antibodies are commonly used in the laboratory for T-cell activating and proliferation, [20,21] but the widespread and indiscriminate activation makes them difficult to apply in vivo due to the risk of dangerous immune storm. [22,23] Therefore, new methods of T-cell activation need to be sought.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Activation of Immune T Cells via a Water Driven Nanomotor

Xie

et al. 2022

Adv Healthcare Materials

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As a key step during immune response, antigen recognition requires direct mechanical interaction between T cells and antigen presenting cells. Upon subjection to mechanical forces, mechanotransduction is triggered. In this study, the mechanical forces generated by water driven synthetic Au-Zn nanomotors are used to activate mechanosensitive Jurkat T cells. The triggering and activation of the cellular Ca 2+ channel is observed. It is revealed that the mechanosensitive cells experience different degrees of activation upon receiving different mechanical input signals and demonstrate that external mechanical forces can optimize T cell activation. Compared with T cell activation with cytokines which can lead to the risky widespread activation of T cells and systemic immune storm, nanomotors can present mechanical force and achieve localized immune cell stimulation. It is expected that mechano nanomotors will contribute to the emerging T cell immunology field and facilitate more comprehensive understanding of the T cell mechanical response and function.

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