Low transcriptional activity of PON2 in recurrent abortion: A novel therapeutic agent?

Dikbaş, Levent; Dur, Rıza; Taş, İ̇smail; Yapça, Ömer Erkan; Dikbaş, Neslihan

doi:10.1016/j.jogoh.2018.06.006

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…PON2 expression is under genetic control and regulated by cellular oxidative stress as well as by cholesterol content (Rosenblat et al 2004 ; Shiner et al 2006 ). Low transcriptional activity of PON2 has been recognized as one of the major culprits in recurrent abortion due to its inadequate antioxidative defense (Dikbas et al 2018 ). Several transcription factors such as peroxisome proliferator-activated receptor γ (PPARγ), sterol regulatory element-binding protein 2(SREBP-2), and activator protein-1 (AP-1) activation are known to upregulate PON2 expression.…”

Section: Regulation Of Pon2 Expressionmentioning

confidence: 99%

Insights into the role of paraoxonase 2 in human pathophysiology

Parween

Gupta

2022

J Biosci

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Paraoxonase 2 (PON2) is a ubiquitously expressed intracellular enzyme that is known to have a protective role from oxidative stress. Clinical studies have also demonstrated the significance of PON2 in the manifestation of cardiovascular and several other diseases, and hence, it is considered an important biomarker. Recent findings of its expression in brain tissue suggest its potential protective effect on oxidative stress and neuroinflammation. Polymorphisms of PON2 in humans are a risk factor in many pathological conditions, suggesting a possible mechanism of its anti-oxidative property probably through lactonase activity. However, exogenous factors may also modulate the expression and activity of PON2. Hence, this review aims to report the mechanism by which PON2 expression is regulated and its role in oxidative stress disorders such as neurodegeneration and tumor formation. The role of PON2 owing to its lactonase activity in bacterial infectious diseases and association of PON2 polymorphism with pathological conditions are also highlighted.

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Section: Regulation Of Pon2 Expressionmentioning

confidence: 99%

Insights into the role of paraoxonase 2 in human pathophysiology

Parween

Gupta

2022

J Biosci

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Paraoxonase 1 Activities in First Trimester Miscarriages

Savaş¹,

Erdem²

2021

Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi

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Aim: Miscarriages are becoming increasingly important problem nowadays. First trimester pregnancy loss frequency in women of reproductive age is increasing.In this study, it is aimed to show the possible relationship between first trimester pregnancy losses and PON1 and ARY activities.Material and Methods: 25 pregnant healthy women (Group 1) and 25 women with first trimester miscarriage Group in -1 gestational weeks were included in this study. Paraoxonase 1 and arylesterase activities of the sera samples were investigated using fully automated colorimetric methods. ANOVA test was used to compare the groups.Results: P 1 and A activities are statistically significantly lower in pregnant women with first trimester miscarriage compared to healthy pregnant women in first trimester analyzed by Anova test p Conclusion:The results of this study showed that paraoxonase 1 and arylesterase antioxidant enzyme activities can be evaluated as significant predictive clinical laboratory parameters in first trimester pregnancy losses If this study is confirmed with larger patient groups, our research results will gain more value.

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Low transcriptional activity of PON2 in recurrent abortion: A novel therapeutic agent?

Cited by 2 publications

References 37 publications

Insights into the role of paraoxonase 2 in human pathophysiology

Insights into the role of paraoxonase 2 in human pathophysiology

Paraoxonase 1 Activities in First Trimester Miscarriages

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