Low titers of measles antibodies in Japanese pregnant women: A single‐center study

Kanda, Eriko; Yamaguchi, Koushi; Hanaoka, Masachi; Sago, Haruhiko; Kubo, Takahiko

doi:10.1111/j.1447-0756.2012.01997.x

Cited by 7 publications

(2 citation statements)

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“…At the time of this outbreak, some mothers in this age group may not have ever had measles and therefore transferred the antibody to their babies; around 50 % might have had vaccine-derived immunity. Even among vaccinated women, antibody levels could be low [ 19 ]. Either way, infants born to these mothers are more susceptible to measles in early infancy.…”

Section: Discussionmentioning

confidence: 99%

The 2013 measles outbreak in Sri Lanka: experience from a rural district and implications for measles elimination goals

et al. 2015

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BackgroundSri Lanka was the first country in the Southeast Asian region to achieve its measles elimination goal in 2011. In 2012, the measles immunization schedule changed from a measles vaccine at 9 months to a measles, mumps and rubella vaccine at 12 months. However in 2013, Sri Lanka reported its worst recent outbreak of measles. This study investigated a part of this outbreak in order to describe its epidemiology.MethodsA prospective study was carried out at the university medical unit of the Teaching Hospital, Anuradhapura (THA), the third largest hospital in Sri Lanka, from October 2013 until March 2014. An epidemiological profile of patients was constructed, case confirmation was done on all suspected cases and the basic demographic details of these suspected cases were obtained from the available records.ResultsFrom January 2013 to March 2014, 101 measles suspects were admitted to the THA. Until June 2013, all suspected cases were aged below 12 months of age. During the study period (15 months), the total number of patients aged below 9 months, 9 to 12 months, 1 to 11 years, 12–29 years and over 29 years were 10 (9.9 %), 11 (10.9 %), 6 (5.9 %), 37 (36.6 %) and 36 (35.6 %), respectively (data missing-1). Out of the 33 patients clinically suspected, 32 tested positive for measles. Common clinical features included: fever (n = 33, 100 %), maculopapular rash (n = 33), conjunctivitis (n = 31), posterior cervical lymphadenopathy (n = 23) and Koplik’s spots (n = 8). Features suggestive of pneumonia were observed among 30 (90.9 %) patients and 26 (78.8 %) had diarrhoea. Two patients (6.1 %) who developed severe pneumonia received care at an intensive care unit due to respiratory difficulties. Out of 33 patients, 15 (45.5 %) had prior immunization for measles, two (6.1 %) reported that they never had a measles immunization and 16 (48.5 %) were unsure about their immunization status. Out of those who reported they were previously immunized, 11 (73.3 %) belonged to the age group of 12–29 years.ConclusionBecause the first cases of this outbreak were infants, an increase in susceptible infants due to the change in the vaccine schedule could partly explain the outbreak.Electronic supplementary materialThe online version of this article (doi:10.1186/s40249-015-0084-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

The 2013 measles outbreak in Sri Lanka: experience from a rural district and implications for measles elimination goals

et al. 2015

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“…Measles remains a rare event in pregnancy in developing countries since most women of child-bearing age acquired measles at a young age. 13 However, in industrialized countries the Measles was an inevitable infection during the human development with substantial degree of morbidity and mortality. The severity of measles virus (Mv) infection was largely contained by the development of a live attenuated vaccine that was introduced into the vaccination programs.…”

Section: Complications With Pregnancymentioning

confidence: 99%

Measles virus

Naim

2014

Human Vaccines & Immunotherapeutics

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Measles in pregnant women: A systematic review of clinical outcomes and a meta-analysis of antibodies seroprevalence

Congera

Maraolo

Parente

et al. 2020

Journal of Infection

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Low titers of measles antibodies in Japanese pregnant women: A single‐center study

Abstract: Our results revealed that 28% of our pregnant population was seronegative or low-positive for measles antibodies, and thought to require revaccination or vaccination. Screening for measles immunity might be advisable for women of childbearing age.

Cited by 7 publications

References 13 publications

The 2013 measles outbreak in Sri Lanka: experience from a rural district and implications for measles elimination goals

The 2013 measles outbreak in Sri Lanka: experience from a rural district and implications for measles elimination goals

Measles virus

Measles in pregnant women: A systematic review of clinical outcomes and a meta-analysis of antibodies seroprevalence

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