Low Thyroidal Iodine Uptake with Euthyroidism Associated with Deficient Thyroid-Binding Globulin But Normal Cortisol Binding<sup>1</sup>

Colonel, Lt; Beisel, William R.; ARMY, U. S.; Zainal, Hadzliana; Hane, Satoshi; DiRaimondo, Vincent C.; Forsham, Peter H.

doi:10.1210/jcem-22-12-1165

Cited by 25 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of 75 males with no measurable TBG-levels only 16 were reported in some greater detail (Tanaka & Starr 1959;Ingbar 1961;Colonel et al 1962;Nikolai & Seal 1966, 1967Kraemer & Wiswell 1968;Torkington et al 1970;Avruskin et al 1972;Leiba et al 1974;Konno 1976;Barragry 1977;BratuschMarrain et al 1979). Few of these have a medical history of severe complicating disease.…”

Section: Discussionmentioning

confidence: 99%

Genetics and clinical significance of thyroxine binding globulin deficiency, an analysis of seven families

Kollind

Iselius

Pettersson

et al. 1985

Acta Endocrinologica

View full text Add to dashboard Cite

Seven families, ascertained through probands with undetectable levels of thyroxine binding globulin (TBG) were studied from clinical and genetic points of view. The blood levels of TBG, thyroxine binding prealbumin (TBPA), thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4) were determined in altogether 128 family members. The concentration of free thyroxine (FT4) was calculated from the concentrations of T4, TBG and TBPA. Only men (n = 15) were found to have total TBG deficiency. Their TSH levels were within normal range and they did not show any clinical symptoms of thyroid dysfunction. The mothers and daughters of the affected men had significantly lower TBG levels than control women. Segregation analysis performed on 46 nuclear families showed significant evidence for an X-linked additive mode of transmission and an additional multifactorial component with heritability 0.47. Familiar TBG-deficiency shows an X-linked mode of transmission and the mechanism has been as¬ sumed to be a single factor inheritance (Refetoff et al. 1972). However, it has also been proposed that TBG-deficiency might be a polygenic trait (Rivas et al. 1971). The aim of this study was to characterize the major locus in terms of gene frequency, dis¬ placement and incomplete dominance and to search for residual family resemblance due to multifactorial inheritance.The clinical importance of total TBG-deficiency is still unclear although there does not seem to be an association between this defect and disturbances in the thyroid function. Relatively few such studies have been carried out. In the present study the clinical aspects of total TBG-deficiency were studied in probands and their family members with total TBG-deficiency with respect to the possibility of an increased morbidity among these affected individuals. Materials and MethodsSeven unrelated subjects with undetectable levels of TBG were ascertained among patients referred to the Depart¬ ment of Clinical Chemistry, Danderyds Hospital, Stock¬ holm, Sweden, during 1976-1981 for laboratory investi¬ gations of the thyroid function. The clinical symptoms of these subjects are summarized in Table 1. Of the 175 family members 128 agreed to give blood for analysis. Among the 45 subjects who rejected the majority were children below 10 years of age. The control material comprised 376 apparantly healthy subjects above 5 years of age.The plasma levels of TBG and TBPA were determined by electroimmunoassay using human standard serum from Behring-werke, Marburg, Germany as a standard (Laurell 1972). The reference range for TBG (mean ± 2 Sd) was found to be 10-23 mg/1 for adult men and 13-25 mg/1 for women. T4 was assayed by a modifica¬ tion of the competitive protein-binding technique of Alexander 8c Jennings ( 1974), i.e. pure TBG was used for the elution of T4 from the Sephadex columns. T3 and TSH were quantitated using commercial radioimmuno-

show abstract

Section: Discussionmentioning

confidence: 99%

Genetics and clinical significance of thyroxine binding globulin deficiency, an analysis of seven families

Kollind

Iselius

Pettersson

et al. 1985

Acta Endocrinologica

View full text Add to dashboard Cite

show abstract

Drug-Macromolecular Interactions: Implications for Pharmacological Activity

Ehrenpreis

1970

Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Recherches Pharmaceutiques

View full text Add to dashboard Cite

Die Defektproteinämien und die Antikörpermangelsyndrome

Brackertz¹,

Müller²

1974

Blut Und Blutkrankheiten

View full text Add to dashboard Cite

Low Thyroidal Iodine Uptake with Euthyroidism Associated with Deficient Thyroid-Binding Globulin But Normal Cortisol Binding¹

Cited by 25 publications

References 0 publications

Genetics and clinical significance of thyroxine binding globulin deficiency, an analysis of seven families

Genetics and clinical significance of thyroxine binding globulin deficiency, an analysis of seven families

Drug-Macromolecular Interactions: Implications for Pharmacological Activity

Die Defektproteinämien und die Antikörpermangelsyndrome

Contact Info

Product

Resources

About

Low Thyroidal Iodine Uptake with Euthyroidism Associated with Deficient Thyroid-Binding Globulin But Normal Cortisol Binding1

Cited by 25 publications

References 0 publications

Genetics and clinical significance of thyroxine binding globulin deficiency, an analysis of seven families

Genetics and clinical significance of thyroxine binding globulin deficiency, an analysis of seven families

Drug-Macromolecular Interactions: Implications for Pharmacological Activity

Die Defektproteinämien und die Antikörpermangelsyndrome

Contact Info

Product

Resources

About

Low Thyroidal Iodine Uptake with Euthyroidism Associated with Deficient Thyroid-Binding Globulin But Normal Cortisol Binding¹