Low-threshold stimulated emission from lysozyme amyloid fibrils doped with a blue laser dye

Sznitko, Lech; Hańczyc, P; Myśliwiec, Jarosław; Samoć, Marek

doi:10.1063/1.4905782

Cited by 17 publications

(19 citation statements)

References 22 publications

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“…For many applications, it is desirable to functionalize such structures with additional materials [24]. For example, by addition of luminescent dyes PNFs can be prepared suitable for applications related to light emission [25][26][27][28]; in addition, interesting nonlinear optical effects have been observed in dye-doped PNF systems [29]. Moreover, dye-doped PNFs may be valuable as, e.g., labeled proteins for amyloidosis studies.…”

Section: Introductionmentioning

confidence: 99%

Preparation of functionalized protein materials assisted by mechanochemistry

Wang

Solin

2018

J Mater Sci

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Herein, we investigate the suitability of hen egg-white lysozyme (HEWL) as a protein matrix for dispersal of various hydrophobic dyes. Moreover, we investigate the use of a mixer mill for grinding operation as an alternative to hand grinding by mortar and pestle. HEWL and various dyes are mixed by mechanochemistry, and the resulting composite material is dissolved in aqueous acid. The samples are then exposed to conditions promoting self-assembly of HEWL into protein nanofibrils (PNFs). The effect of PNF formation on dye photophysics is investigated by spectroscopic examination by absorption and luminescence spectroscopy, and product morphology is examined by scanning electron microscopy. The self-assembly process results in protein nanofibrils functionalized with luminescent dyes. Such structures may find future applications in various devices for light emission. In addition, we demonstrate that the anticancer drug camptothecin can be incorporated into protein nanofibrils giving materials that can find application as drug delivery agents.

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Section: Introductionmentioning

confidence: 99%

Preparation of functionalized protein materials assisted by mechanochemistry

Wang

Solin

2018

J Mater Sci

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“…The results reported herein are thus of importance for the formation of functionalized amyloid fibrils that can be used in organic electronics and photonics applications. The use of various protein structures for such applications is attracting increasing interest and development of methods to prepare fibril dispersions are thus of high importance.…”

Section: Discussionmentioning

confidence: 99%

Controlling amyloid fibril formation by partial stirring

2016

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Many proteins undergoe self-assembly into fibrillar structures known as amyloid fibrils. During the self-assembly process, related structures known as spherulites can be formed. Herein we report a facile method where the balance between amyloid fibrils and spherulites can be controlled by stirring of the reaction mixture during the initial stages of the self-assembly process. Moreover, we report how this methodology can be used to prepare non-covalently functionalized amyloid fibrils. By stirring the reaction mixture continuously or for a limited time during the lag phase, the fibril length, and hence the propensity to form liquid crystalline phases, can be influenced. This phenomena is utilized in order to prepare films consisting of aligned protein fibrils incorporating the laser dye Nile red. The resulting films display polarized Nile red fluorescence.

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“…WGM lasing has also been achieved in BSA microdisks . Lasing from starch microspheres and slab planar waveguides of the lysozyme amyloid fibrils were also reported. Additionally, poly(lactic‐co‐glycolic acid) (PLGA) and poly(lactic acid) (PLA) (both are approved for medical use) have been employed for laser resonators.…”

Section: Soft‐matter Microlasers: Soft Materialsmentioning

confidence: 98%

Microlasers Enabled by Soft‐Matter Technology

Wang

Sun

2019

Advanced Optical Materials

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Soft‐matter microlasers are an interesting part of soft‐matter photonics, which are based on liquids, liquid crystals, polymers, biological materials, and fabricated mainly by solution‐processing approaches. Soft‐matter microlasers comprehend a multitude of attractive features, including low‐cost, mechanical flexibility, wide range wavelength tunability and, in some cases, biocompatibility, and biodegradability. As such, they are recognized as versatile candidates for efficient light sources with enhanced performances and applications as ultrasensitive physical, chemical, and biological sensors. Here, the recent developments of soft‐matter microlasers are reviewed in time and the prospect in this field is provided. First, the characteristics of the representative soft‐matter microlasers are discussed with focus on their laser structures, lasing mechanisms, fabrication approaches, and gain material origins, followed by an introduction about the current cutting‐edge soft‐technologies that are applied in soft‐matter microlasers. Afterward, their potential applications as wavelength tunable sources, sensors, and displays are highlighted. Finally, the work is summarized and the prospect of soft‐matter microlasers for expanding this emerging research field is presented.

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Low-threshold stimulated emission from lysozyme amyloid fibrils doped with a blue laser dye

Cited by 17 publications

References 22 publications

Preparation of functionalized protein materials assisted by mechanochemistry

Preparation of functionalized protein materials assisted by mechanochemistry

Controlling amyloid fibril formation by partial stirring

Microlasers Enabled by Soft‐Matter Technology

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