Low testosterone levels relate to poorer cognitive function in women in an APOE-ε4-dependant manner
Melanie A. Dratva,
Sarah J. Banks,
Matthew S. Panizzon
et al.
Abstract:Background
Past research suggests that low testosterone levels relate to poorer cognitive function and higher Alzheimer’s disease (AD) risk; however, these findings are inconsistent and are mostly derived from male samples, despite similar age-related testosterone decline in females. Both animal and human studies demonstrate that testosterone’s effects on brain health may be moderated by apolipoprotein E ε4 allele (APOE-ε4) carrier status, which may explain some previous inconsistencies. We exa… Show more
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