Low-Temperature Synthesis of Hybrid Nanoforms Based on the Antibacterial Drug Dioxidine and Nanoparticles of Bioactive Metals (Silver, Copper) Incorporated into Biopolymer Cryogels

Шабатина, Т. И.; Vernaya, O. I.; Nuzhdina, A. V.; Шабатин, В. П.; Semenov, A. M.; Melnikov, M.Y.

doi:10.1134/s0036024419100261

Cited by 4 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[30][31][32][33] Several years later, fabrication of polymer based cryogels was extended to involve the addition of inorganic nanocrystals. Several works on cryogels obtained from mixing polymeric matrices with various types of nanoparticles have been reported including Ag, [23,24,[34][35][36][37][38][39][40][41][42][43][44][45][46][47] Au, [48][49][50][51][52][53][54] Pd, [55,56] Pt, [55,56] Co, [57][58][59][60][61][62][63] Ni, [59][60][61][62][63][64] Cu, [60][61][62]64,65] Fe 3 O 4, [66]…”

Section: Fabrication and Macro-structuringmentioning

confidence: 99%

“…Several years later, fabrication of polymer based cryogels was extended to involve the addition of inorganic nanocrystals. Several works on cryogels obtained from mixing polymeric matrices with various types of nanoparticles have been reported including Ag, [23,24,34–47] Au, [48–54] Pd, [55,56] Pt, [55,56] Co, [57–63] Ni, [59–64] Cu, [60–62,64,65] Fe 3 O 4, [66–71] ZnO, [72,73] SiO 2, [74] AlO 3, [75] SnO 2, [76] On one hand, the presence of the polymer matrix gives the cryogel material some features including: elastic texture, high water retention capacity and biocompatibility [16,77] . On the other hand, incorporation of inorganic nanoparticles adds other physical and chemical properties to the cryogel structure and allows the preparation of thermo‐responsive, fluorescent, conductive and magnetic cryogels, for example [78–81] …”

Section: Fabrication and Macro‐structuringmentioning

confidence: 99%

See 1 more Smart Citation

Nanoparticle‐Based Cryogels from Colloidal Aqueous Dispersion: Synthesis, Properties and Applications

Borg,

Morales,

Dorfs

et al. 2024

ChemNanoMat

View full text Add to dashboard Cite

Cryogels have morphological features that make them interesting for several applications such as catalysis, sensing or tissue engineering. Their interconnected network and open porous structure, build up by primary particles (such as inorganic nanocrystals or polymers), provide these materials with unique physical properties and high specific surface areas. While the library of cryogels is endless, widely used in the polymer chemistry field, in this review we will summarize the structure and properties, applications and challenges of inorganic nanocrystal‐based cryogels obtained by freezing and freeze‐drying an aqueous nanoparticle colloid. This fast, easy and versatile gelation method will be outlined, along with the corresponding macro‐, micro‐ and nano‐structures and gel morphologies that can be obtained, for example, by changing the freezing temperature or by using one nanoparticle system or nanoparticle mixtures. Their applications towards electrocatalysis, photocatalysis and photoelectrochemical sensing will be highlighted, as well as the challenges and prospects of these materials.

show abstract

Section: Fabrication and Macro-structuringmentioning

confidence: 99%

Section: Fabrication and Macro‐structuringmentioning

confidence: 99%

Nanoparticle‐Based Cryogels from Colloidal Aqueous Dispersion: Synthesis, Properties and Applications

Borg,

Morales,

Dorfs

et al. 2024

ChemNanoMat

View full text Add to dashboard Cite

show abstract

“…Moreover, temperature and pressure play a decisive role in the formation of certain polymorphic modifications, since they determine the conditions of their stability and solubility. Let us consider specific examples of the cryochemical synthesis of nanosized drug powders [56,57,[68][69][70][71][72][73][74][75][76][77][78].…”

Section: Cryogenic Technologies (Cryogenic Freeze Drying Of Water Sol...mentioning

confidence: 99%

“…Dioxidine (2,3-bis-(hydroxymethyl)quinoxaline-N,N,N′-dioxide) is a widely used antimicrobial agent known for effectively inhibiting the growth of numerous Gram-positive and Gram-negative bacteria (Figure 15) [72][73][74][75][76][77][78]. The initial Dioxidine powder underwent cryochemical modification through two methods: freeze-drying of sprayed frozen aqueous solution and low-temperature condensation of molecular vapor from the gas state.…”

Section: Dioxidinementioning

confidence: 99%

See 1 more Smart Citation

Pharmaceutical Nanoparticles Formation and Their Physico-Chemical and Biomedical Properties

Shabatina,

Gromova,

Vernaya

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

The use of medicinal substances in nanosized forms (nanoforms, nanoparticles) allows the therapeutic effectiveness of pharmaceutical preparations to be increased due to several factors: (1) the high specific surface area of nanomaterials, and (2) the high concentration of surface-active centers interacting with biological objects. In the case of drug nanoforms, even low concentrations of a bioactive substance can have a significant therapeutic effect on living organisms. These effects allow pharmacists to use lower doses of active components, consequently lowering the toxic side effects of pharmaceutical nanoform preparations. It is known that many drug substances that are currently in development are poorly soluble in water, so they have insufficient bioavailability. Converting them into nanoforms will increase their rate of dissolution, and the increased saturation solubility of drug nanocrystals also makes a significant contribution to their high therapeutic efficiency. Some physical and chemical methods can contribute to the formation of both pure drug nanoparticles and their ligand or of polymer-covered nanoforms, which are characterized by higher stability. This review describes the most commonly used methods for the preparation of nanoforms (nanoparticles) of different medicinal substances, paying close attention to modern supercritical and cryogenic technologies and the advantages and disadvantages of the described methods and techniques; moreover, the improvements in the physico-chemical and biomedical properties of the obtained medicinal nanoforms are also discussed.

show abstract

Cryoformation and Properties of Dioxidine/Gelatin Systems

Vernaya

Shumilkin²,

Karlova³

et al. 2022

Moscow Univ. Chem. Bull.

View full text Add to dashboard Cite

Low-Temperature Synthesis of Hybrid Nanoforms Based on the Antibacterial Drug Dioxidine and Nanoparticles of Bioactive Metals (Silver, Copper) Incorporated into Biopolymer Cryogels

Cited by 4 publications

References 17 publications

Nanoparticle‐Based Cryogels from Colloidal Aqueous Dispersion: Synthesis, Properties and Applications

Nanoparticle‐Based Cryogels from Colloidal Aqueous Dispersion: Synthesis, Properties and Applications

Pharmaceutical Nanoparticles Formation and Their Physico-Chemical and Biomedical Properties

Cryoformation and Properties of Dioxidine/Gelatin Systems

Contact Info

Product

Resources

About