Low temperature photothermal therapy: Advances and perspectives

H2O2‐Responsive NIR‐II AIE Nanobomb for Carbon Monoxide Boosting Low‐Temperature Photothermal Therapy

“…Various low‐temperature PTT strategies through inhibition of the expression of HSPs has attracted a worldwide interest. Small molecular HSPs inhibitor and small‐interfering RNA (siRNA) have been loaded with various PTAs through covalent interaction, electrostatic interaction, π–π interaction, etc [13] . Under appropriate laser irradiation power and time, these composites could ablate tumor tissue under the low‐temperature range from 38 °C to 43 °C.…”

“…Small molecular HSPs inhibitor and small-interfering RNA (siRNA) have been loaded with various PTAs through covalent interaction, electrostatic interaction, π-π interaction, etc. [13] Under appropriate laser irradiation power and time, these composites could ablate tumor tissue under the low-temperature range from 38 °C to 43 °C. Loading small-molecular HSP inhibitors with PTAs nanoplatforms is one of the simple strategies to achieve tumor ablation under low-temperature.…”

Photovoltaic molecules with ultra-high light energy utilization for near-infrared laser triggered synergetic photodynamic and photothermal therapy

“…9–11 Considering the hypoxic tumor microenvironment and the presence of heat shock proteins, the combination of PDT and PTT can achieve better therapeutic efficacy. 12,13…”

“…[9][10][11] Considering the hypoxic tumor microenvironment and the presence of heat shock proteins, the combination of PDT and PTT can achieve better therapeutic efficacy. 12,13 In addition to ROS generation capability and photothermal conversion efficiency (PCE), the wavelength of excitation light also has a great impact on the efficacy of phototherapy. Nearinfrared (NIR) light with wavelengths located in biological windows has a strong tissue penetrating ability, and thus the deep cancer cells could be effectively killed by NIR laser excitation during phototherapy.…”

A nanoplatform for mild-temperature photothermal and type I & II photodynamic therapy in the NIR-II biowindow

“…So mild-temperature photothermal therapy, i.e., one generating a temperature of less than 45 1C, is expected to have increasingly greater practicability in the clinic. 11,12 For PDT, there are relatively few organic photosensitizers with dual type I and II PDT activities ( 1 O 2 , OH) that enhance hypoxia-tolerant photodynamic efficacy. 3,[13][14][15] Therefore, the development of organic photosensitizers with both type I and II PDT would be beneficial for improving cancer treatment efficacy.…”