The effect of irradiation with helium ions at T = 350°C with an energy of 20 keV and a dose of 1.5·1018 Не/cm2 on the structure and properties of VT1-0 titanium alloy in the initial and nanostructural states was studied. It has been shown that irradiation of VT1-0 samples in the initial state leads to a decrease in mechanical properties when tested under creep conditions at T = 350 °C, which may be due to dynamic recovery. A material in a nanostructured state is characterized by an increase in strength and creep rate at a test temperature of T = 350°C, while maintaining a plasticity reserve. The effect is associated with the structure rearrangement, grain growth and the development of strain hardening processes as the effective stress increases.