Low-Temperature Inactivation of Enzyme-like Activity of Nanocrystalline CeO2 Sols

Filippova, Arina D.; Sozarukova, Madina M.; Баранчиков, А. Е.; Egorova, A. A.; Cherednichenko, Kirill A.; Иванов, В. К.

doi:10.1134/s0036023622601581

Cited by 6 publications

(3 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…При выборе синтеза стоит иметь в виду, что есть данные о том, что обработка наночастиц CeO 2 при высоких температурах ведет не только к потере ан тиоксидантной активности, но и к приобретению прооксидантных свойств [5,9,22,23].…”

Section: выбор методики синтезаunclassified

See 1 more Smart Citation

Nanomaterials based on cerium oxide nanoparticles for wound regeneration: a literature review

Silina,

Manturova,

Erokhina

et al. 2023

RJTAO

View full text Add to dashboard Cite

Objective: to analyze data on the synthesis and properties of cerium oxide nanoparticles, as well as the prospects of its application in regenerative medicine for wound healing. Methodology. World literature was reviewed using PubMed, SCOPUS, ResearchGate, CyberLeninck, and Elibrary databases, as well as manual searches for authors and reference lists. Key search terms were «cerium oxide» AND nano* AND (healing OR regeneration OR repair) AND wound». The timeline was from the date of publication through August 2023. Results. The final analysis included 59 sources containing information on the synthesis and size of nanoparticles (and/or other physicochemical characteristics), methodology and results of in vivo and in vitro studies on the efficacy and/or safety of nanoceria for wound regeneration. It is shown that despite the progressive growth of research interest over the last 15 years, the actual use of nanoceria in practical medicine is still not widespread. This is due to a wide variety of non-standardized synthesis methods and conditions, resulting in the variability of physicochemical parameters of nanoparticles (size, form), thereby affecting the safety and biomedical efficacy of nanoceria. Regeneration mechanisms, including the antioxidant-prooxidant, anti-inflammatory and antimicrobial effects of nanoceria, which contribute to accelerated wound healing, are discussed. The severity of the regenerative effects depends on the method and conditions of synthesis, hence the resulting physicochemical characteristics of the nanoparticles. Therefore, after each batch, newly synthesized nanoceria needs physicochemical and biomedical experimental tests. Conclusion. Nanoceria has great potential in tissue engineering for regenerative medicine, particularly for healing of various kinds of wounds. Having developed a technology for standardized synthesis for effective and safe nanoceria (of the right form and size) on a production scale, it can be introduced in medicine, possibly improving the outcomes of treatment of many diseases and pathologies. The authors present conclusions on the results of the study of nanoceria for accelerating qualitative regeneration and the requirements for nanoparticles obtained during synthesis.

show abstract

Section: выбор методики синтезаunclassified

“…От размера и формы частиц зависит редоксак тивность наноцерия и проявляемая биологическая активность [22,23], поэтому эти характеристики наноцерия являются принципиальными.…”

Section: форма и размер наночастицunclassified

Nanomaterials based on cerium oxide nanoparticles for wound regeneration: a literature review

Silina,

Manturova,

Erokhina

et al. 2023

RJTAO

View full text Add to dashboard Cite

show abstract

“…One of the promising inorganic nanobiomaterials possessing enzyme-like activity along with unique physical and chemical properties is nanoscale cerium dioxide [1][2][3][4][5][6][7]. Biochemical activity of CeO 2 nanoparticles, being similar to the functions of a number of natural enzymes, such as superoxide dismutase (SOD) [8][9][10][11], catalase [12][13][14], peroxidase [15][16][17][18], phosphatase [19], phospholipase [20], photolyase [21], uricase [22], etc., expands the prospects for their biomedical application for the prevention, diagnosis, and therapy of socially significant diseases [23][24][25] and requires a comprehensive analysis of the properties of nanoscale cerium dioxide, including its interaction with blood components, both alone, and as part of combination therapy, for example, with ultraviolet irradiation of blood (UVIB).…”

Section: Introductionmentioning

confidence: 99%

Cerium dioxide nanoparticles modulate the oxidative metabolism of neutrophils upon blood irradiation with a pulsed broadband UV source

Sozarukova,

Chilikina,

Novikov

et al. 2023

Nanosystems: Phys. Chem. Math.

View full text Add to dashboard Cite

The effect of CeO 2 nanoparticles on the oxidative activity of neutrophils under UV irradiation with a pulsed broadband UV source (210 mJ/cm 2 ) was analyzed. The effects of citrate-stabilized CeO 2 sol on spontaneous and stimulated by phorbol-12-myristate-13-acetate (PMA) and N-formylmethionyl-leucyl-phenylalanine (fMLP) luminol-dependent chemiluminescence of neutrophils were evaluated. The activating effect of CeO 2 nanoparticles on the spontaneous and suppressive effect on the stimulated chemiluminescence of blood neutrophils from apparently healthy donors was shown, with the most pronounced activating effect of CeO 2 nanoparticles revealed in the blood sample with initially high radical-producing cell activity. Under UV irradiation of blood at a dose of 210 mJ/cm 2 CeO 2 nanoparticles enhance both spontaneous and stimulated radical-producing function of neutrophils. Probably, the suppressive and activating effects of citrate-stabilised cerium dioxide sol may be due to the antioxidant activity of CeO 2 nanoparticles with respect to hypochlorite ions and prooxidant activity with respect to hydrogen peroxide.

show abstract

Antioxidant Activity of Conjugates of Cerium Dioxide Nanoparticles with Human Serum Albumin Isolated from Biological Fluids

Sozarukova,

Proskurnina,

Baranchikov

et al. 2023

Russ. J. Inorg. Chem.

View full text Add to dashboard Cite

Low-Temperature Inactivation of Enzyme-like Activity of Nanocrystalline CeO2 Sols

Cited by 6 publications

References 63 publications

Nanomaterials based on cerium oxide nanoparticles for wound regeneration: a literature review

Nanomaterials based on cerium oxide nanoparticles for wound regeneration: a literature review

Cerium dioxide nanoparticles modulate the oxidative metabolism of neutrophils upon blood irradiation with a pulsed broadband UV source

Antioxidant Activity of Conjugates of Cerium Dioxide Nanoparticles with Human Serum Albumin Isolated from Biological Fluids

Contact Info

Product

Resources

About