Low-temperature bonded glass-membrane microfluidic device for in vitro organ-on-a-chip cell culture models

Pocock, Kyall; Gao, Xiaofang; Wang, Chenxi; Priest, Craig; Prestidge, Clive A.; Mawatari, Kazuma; Kitamori, Takehiko; Thierry, Benjamin

doi:10.1117/12.2202461

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2017

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“…Furthermore, if bio-chemical substances or coatings need to be present prior to bonding, substantial heating of the substrates is undesirable [6,7]. Several approaches towards a lower glass bonding temperature have been developed over the years [3].…”

Section: Introductionmentioning

confidence: 99%

Laser welding of pre-functionalized glass substrates: a fabrication and chemical stability study

Carvalho

Reuvekamp

Zuilhof

et al. 2017

J. Micromech. Microeng.

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Low-temperature bonding of glass substrates is of great interest in the field of microfluidic-based biosensing, and we study how laser welding could be used for this. This technology allows for the modification of glass channels with temperature-sensitive materials prior to bonding. We study the effects of the welding process by investigation of the thermal degradation of a biotin monolayer and whether it retains the ability to conjugate with fluorescently-labelled streptavidin.

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Section: Introductionmentioning

confidence: 99%