Low-tar filter cigarettes and an aggressive type of lung cancer

Boon, Jeroen van der

doi:10.1016/s1470-2045(00)00310-7

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The appearance of low-tar cigarettes parallels changing the epidemiology of the lung cancer. Thus, increasing incidence of an adenocarcinoma of the lung was linked to the use of so-called light cigarettes (26)(27)(28)(29). As it is evident from Fig.…”

Section: Resultsmentioning

confidence: 93%

“…In the ambient air at moderate temperatures, all hydrocarbon alkyl radicals (R ) are converted into peroxyl-radical species (ROO ) (25). Thus, the strategy behind the analytical use of the latter chemiluminescent system is based on the competition between a disproportionation of peroxyl radicals giving rise to light emission and scavenging the peroxyl radicals by antioxidants resulting in the chemiluminescence quenching (21,22,(26)(27)(28)(29). On gradual consumption of the antioxidative species, the chemiluminescence intensity recovers and the recovery kinetics reflects the type of the antioxidant.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Chemiluminescence of Cigarette Smoke: Salient Features of the Phenomenon

Fedorova

Menshov

Trofimov

et al. 2017

Photochem & Photobiology

View full text Add to dashboard Cite

The study disclosed herein provides for the first time a detailed experimental support for the general mechanism of the cigarette-smoke-derived chemiluminescence, as an example par excellence of the excited-state generation in a chemically complex aerosol medium. The mechanism involves chemiexcitation in a unimolecular transformation of the smoke-borne free radical species. However, the concentration of these radicals, [r∙], obeys a bimolecular (second-order) kinetics and depends on a particulate-phase content (total particulate matter, TPM) of the cigarette smoke. The decrease in [r∙] with increasing the TPM amount manifests radical-scavenging propensity of the smoke particulate phase. Astonishingly, no energy transfer takes place from the primary excited light-emitting species to luminophoric molecules abundant in the smoke. The reported results build up fundamentals of a facile chemiluminescence assay for free radical properties of the smoke. The experimental approaches developed for this study are of general scope and may be used for mechanistic elucidation of the excited-state generation in chemical systems and environments of an arbitrary complexity.

show abstract

Section: Resultsmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Chemiluminescence of Cigarette Smoke: Salient Features of the Phenomenon

Fedorova

Menshov

Trofimov

et al. 2017

Photochem & Photobiology

View full text Add to dashboard Cite

show abstract

“…This increase of AD was related to the introduction of cigarette with filter [12]. This new smoking habit appeared to be more carcinogenic through the increasing incidence of AD, the most aggressive and metastasis cell types of lung carcinoma [19]. The smoker of cigarette with filter is more exposed to tobacco nitrosamines (TSNs) in particular the 4-methylnitrosamino-1-3-pyridyl-1-butanone (NNK); a potent carcinogen which induce lung tumors in the peripheral lung regions, the areas where the AD occurs [12,20].…”

Section: Discussionmentioning

confidence: 99%

Effects of change in smoking habits on bladder cancer incidence in Tunisia

Mrizak¹,

B’chir²,

Jaidane³

et al. 2011

Health

View full text Add to dashboard Cite

Bladder cancer is among the most frequently diagnosed cancer. Tobacco smoking exposures involving nitrosamines and aromatic amines are the main cause of bladder cancer. Although cigarette consumption has gradually decreased, an increased incidence of bladder cancer was registered among males Tunisian for the last two decades. A similar increased incidence of lung adenocarcinoma and bladder cancer was registered among Tunisian males. Epidemiological results suggest that changes in cigarette smoking may be the cause of the increased incidence of bladder cancer. The relationship between CYP1A2 enzyme activities, a key enzyme for activation of bladder carcinogens, and bladder cancer risk was investigated. Variations in CYP1 A2 activities measured in patients with bladder cancer and healthy smokers showed a signifycantly higher CYP1A2 metabolic activity in patient group. Changing in cigarette smoking habits associated to the variation in CYP1A2 activity seem to explain partly the increase incidence of bladder cancer observed in Tunisian male population.

show abstract

“…An increasing incidence of an aggressive type of lung adenocarcinoma was observed in Dutch men [42] showing a shift towards a more rapidly metastasizing type and characterized by an increased resistance to treatment when compared to those occurring in the past. The author suggests that the increase of the incidence of lung Ad and especially the shift of the biological behavior towards an aggressive form has been the different smoking patterns due to the use of light and mild filter cigarettes.…”

Section: Epidemiological Factorsmentioning

confidence: 96%