Low T3 syndrome in canine babesiosis associated with increased serum IL-6 concentration and azotaemia

Zygner, Wojciech; Gójska-Zygner, Olga; Bąska, Piotr; Długosz, Ewa

doi:10.1016/j.vetpar.2015.04.023

Cited by 21 publications

(24 citation statements)

References 30 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar increases in cytokine concentrations have been reported in other studies on canine piroplasmoses, such as B . canis [ 31 , 32 ], B . gibsoni [ 7 ] and Rangelia vitalli [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Because of the highly inflammatory nature of canine babesiosis [ 2 , 3 ], increased concentrations of the pro-inflammatory cytokine IL-6 would be expected as has been described in humans and dogs with sepsis [ 34 , 35 ], as well as dogs with piroplasmoses [ 32 , 33 ]. In our study high concentrations for IL-6 were recorded in the Babesia -infected dogs, but the lack of significance between the Babesia -infected dogs and controls could be a result of the wide range present within each group and the substantial overlap between the ranges.…”

Section: Discussionmentioning

confidence: 99%

“…However, IL-6 was significantly higher in the Babesia -infected dogs that died compared to those that survived. IL-6 plays a central role in the host defence during inflammation caused by infections and has a variety of biological effects, including induction of acute phase protein production, such as CRP and SAA, by the hepatocytes, stimulation of adrenocorticotropic hormone, as well as secretion of cortisol, suppression of the hypothalamic-pituitary-thyroid axis, activation of B- and T-lymphocytes, and modulation of haematopoiesis [ 10 , 32 , 36 ]. In our study concentrations for CRP and SAA were significantly increased in the Babesia -infected group, indicating that IL-6 is associated with an inflammatory state in babesiosis, despite the fact that concentrations were not significantly different from the control dogs.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study showed a strong negative correlation between IL-6 and triiodothyronine (T3) in dogs infected with B . canis [ 32 ]. A lack of consistently high concentrations of IL-6 has been reported in other inflammatory diseases in dogs such as IMHA, pyometra and cervical spondylomyelopathy [ 30 , 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Excessive Pro-Inflammatory Serum Cytokine Concentrations in Virulent Canine Babesiosis

et al. 2016

View full text Add to dashboard Cite

Babesia rossi infection causes a severe inflammatory response in the dog, which is the result of the balance between pro- and anti-inflammatory cytokine secretion. The aim of this study was to determine whether changes in cytokine concentrations were present in dogs with babesiosis and whether it was associated with disease outcome. Ninety-seven dogs naturally infected with B. rossi were studied and fifteen healthy dogs were included as controls. Diagnosis of babesiosis was confirmed by polymerase chain reaction and reverse line blot. Blood samples were collected from the jugular vein at admission, prior to any treatment. Cytokine concentrations were assessed using a canine-specific multiplex assay on an automated analyser. Serum concentrations of interleukin (IL)-2, IL-6, IL-8, IL-10, IL-18, granulocyte-macrophage colony stimulating factor (GM-CSF) and monocyte chemotactic protein-1 (MCP-1) were measured. Twelve of the Babesia-infected dogs died (12%) and 85 survived (88%). Babesia-infected dogs were also divided into those that presented within 48 hours from displaying clinical signs, and those that presented more than 48 hours after displaying clinical signs. Cytokine concentrations were compared between the different groups using the Mann-Whitney U test. IL-10 and MCP-1 concentrations were significantly elevated for the Babesia-infected dogs compared to the healthy controls. In contrast, the IL-8 concentration was significantly decreased in the Babesia-infected dogs compared to the controls. Concentrations of IL-6 and MCP-1 were significantly increased in the non-survivors compared to the survivors. Concentrations for IL-2, IL-6, IL-18 and GM-CSF were significantly higher in those cases that presented during the more acute stage of the disease. These findings suggest that a mixed cytokine response is present in dogs with babesiosis caused by B. rossi, and that an excessive pro-inflammatory response may result in a poor outcome.

show abstract

“…Similar increases in cytokine concentrations have been reported in other studies on canine piroplasmoses, such as B . canis [ 31 , 32 ], B . gibsoni [ 7 ] and Rangelia vitalli [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Excessive Pro-Inflammatory Serum Cytokine Concentrations in Virulent Canine Babesiosis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…W pracach tych zasugerowano, że za występowanie zjawiska obniżenia stężenia hormonów tarczycy, określanego jako zespół eutyreozy chorobowej lub zespół niskiej trójjodotyroniny (T3), odpowiadać może zwiększona produkcja cytokiny prozapalnej IL-6, która działa stymulująco na oś podwzgórze-przysadka-nadnercza i hamująco na oś podwzgórze-przysadka-tarczyca (63). W kolejnych badaniach pracowników WMW SGGW, których wyniki opublikowano w 2015 r., potwierdzono wpływ zwiększonej produkcji IL-6 na hamowanie osi podwzgórze-przysadka-tarczyca u psów z babeszjozą oraz wykazano występowanie korelacji pomiędzy stężeniem całkowitej T3, IL-6 i poziomem azotemii (72).…”

Section: Over 20 Years Of Research On Canine Babesiosis At the Facultunclassified

Over 20 years of research on canine babesiosis at the Faculty of Veterinary Medicine of WULS-SGGW in Warsaw

Zygner

Gójska-Zygner

Górski

et al. 2017

Medycyna Weterynaryjna

Self Cite

View full text Add to dashboard Cite

Canine babesiosis is a tick-borne disease caused by infection with protozoa of the genus Babesia. During over 20 years of studies on canine babesiosis at the Faculty of Veterinary Medicine of the Warsaw University of Life Sciences, the researchers have identified the species of the parasite and its vector in Poland, determined the cause of azotemia and observed other pathological changes, such as endocrine disorders, changes in the de Ritis quotient, as well as biochemical and hematological changes. It was shown that the tick Dermacentor reticulatus is the only vector of canine babesiosis in Poland and the disease is caused by Babesia canis (formerly known as Babesia canis canis). The first studies of pathological changes confirmed the results of previous research in other countries, in which the most prevalent changes in canine babesiosis were thrombocytopenia, anemia leucopenia, increased activity of liver enzymes (ALT, AST, ALP), azotemia, hypoalbuminemia, hypoglycemia, hyponatremia and hypokalemia. Research on azotemia in dogs infected with B. canis showed the contribution of TNF-α overproduction to hypotension and its influence on renal ischemia, hypoxia and the development of azotemia. Moreover, in research on endocrine disorders in canine babesiosis, it was shown that IL-6 overproduction leads to the suppression of the hypothalamic-pituitary-thyroid axis resulting in euthyroid sick syndrome, and that secondary hyperaldosteronism results from decreased renal blood flow and leads to hypokalemia. The results of the research were published in 27 original papers, 6 case reports and many review articles in veterinary journals. These studies provided veterinary surgeons in Poland with improved procedures for diagnosing canine babesiosis, as well as allowed them to better understand some pathogenic mechanisms of the disease and to develop more efficacious therapies..

show abstract

Disturbance of thyroid function in canine ehrlichiosis and babesiosis associated with oxidative stress

Chethan

Garkhal

2016

Comp Clin Pathol

View full text Add to dashboard Cite

Low T3 syndrome in canine babesiosis associated with increased serum IL-6 concentration and azotaemia

Cited by 21 publications

References 30 publications

Excessive Pro-Inflammatory Serum Cytokine Concentrations in Virulent Canine Babesiosis

Excessive Pro-Inflammatory Serum Cytokine Concentrations in Virulent Canine Babesiosis

Over 20 years of research on canine babesiosis at the Faculty of Veterinary Medicine of WULS-SGGW in Warsaw

Disturbance of thyroid function in canine ehrlichiosis and babesiosis associated with oxidative stress

Contact Info

Product

Resources

About