Low‐stress hemolysis in laminar blood flow: Bulk and surface effects in capillaries

Beissinger, Richard L.; Laugel, Jean-Francois

doi:10.1002/aic.690330112

Cited by 14 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, also the time of exposure plays a role (which is equivalent to a finite distance along the path due to the advection velocity). This is wellknown in stress induced hemolysis [26]. The results for the averaged peak shear stresses σ max as a function of Re are presented in Fig.…”

Section: Resultsmentioning

confidence: 65%

Inertia effects and stress accumulation in a constricted duct: A combined experimental and lattice Boltzmann study

Krüger,

Fallah,

Varnik

et al. 2010

Preprint

View full text Add to dashboard Cite

We experimentally and numerically investigate the flow of a Newtonian fluid through a constricted geometry for Reynolds numbers in the range 0.1 − 100. The major aim is to study non-linear inertia effects at larger Reynolds numbers (>10) on the shear stress evolution in the fluid. This is of particular importance for blood flow as some biophysical processes in blood are sensitive to shear stresses, e.g., the initialization of blood clotting. We employ the lattice Boltzmann method for the simulations. The conclusion of the predictions is that the peak value of shear stress in the constriction grows disproportionally fast with the Reynolds number which leads to a non-linear shear stress accumulation. As a consequence, the combination of constricted blood vessel geometries and large Reynolds numbers may increase the risk of undesired blood clotting.

show abstract

Section: Resultsmentioning

confidence: 65%

Inertia effects and stress accumulation in a constricted duct: A combined experimental and lattice Boltzmann study

Krüger,

Fallah,

Varnik

et al. 2010

Preprint

View full text Add to dashboard Cite

show abstract

“…Wu et al 26 were able to show that the critical limit of shear stresses determined with a frequently used Couette viscometer is only of limited significance for the occurrence of haemolysis. Beissinger and Laugel 27 were also able to demonstrate that the haemolysis level increases when the erythrocytes get into contact with foreign materials, regardless of the shear rate present. The presence of free radicals in the blood, which can have an oxidative effect on the erythrocytes, has also reduced their deformability.…”

Section: Resistance Of Erythrocytesmentioning

confidence: 92%

Haemolysis induced by mechanical circulatory support devices: unsolved problems

Köhne

2020

Perfusion

View full text Add to dashboard Cite

Since the use of continuous flow blood pumps as ventricular assist devices is standard, the problems with haemolysis have increased. It is mainly induced by shear stress affecting the erythrocyte membrane. There are many investigations about haemolysis in laminar and turbulent blood flow. The results defined as threshold levels for the damage of erythrocytes depend on the exposure time of the shear stress, but they are very different, depending on the used experimental methods or the calculation strategy. Here, the results are resumed and shown in curves. Different models for the calculation of the strengths of erythrocytes are discussed. There are few results reported about tests of haemolysis in blood pumps, but some theoretical approaches for the design of continuous flow blood pumps according to low haemolysis have been investigated within the last years.

show abstract

“…Hemolysis was observed both in-bulk (including cell-cell and direct shear) and at solid surface and air interfaces (e.g. [20][21][22]), with the material of the blood-contacting surface potentially able to influence RBC damage (e.g. [13,23]).…”

Section: Flow Considerationsmentioning

confidence: 99%

Impact of the Oscillating Bead Size and Shape on Induced Mechanical Stress on Red Blood Cells and Associated Hemolysis in Bead Milling

Tarasev¹,

Muchnik²,

Chakraborty³

2019

Int J Blood Res Disord

View full text Add to dashboard Cite

Background: While in circulation, red blood cells (RBC) need to elastically undergo large deformations without lysing, an ability that may be compromised by cell membrane damage. Such can be tested in vitro by subjecting an RBC sample to external mechanical stress, e.g. through bead milling or oscillation of an object in a sample. In addition to controlling frequency and duration of oscillations, this approach can be further tailored by bead selection/design.Objective: This work studies effects of different beads in creating qualitatively as well as quantitatively different shear stresses when oscillated in a sample containing RBC.Methods: Identical, diluted RBC samples were stressed via bead milling using different beads, with hemolysis profiles developed in each case.Results: Bead dimensions significantly impacted induced stress, both in magnitude as well as type, as reflected by hemolysis under respective conditions. Specifically, cell protection (from lysis) afforded by albumin (when present in the medium) showed a complex dependence on bead length and diameter, with the effect seemingly indicative of multiple combined stresses induced by the bead oscillation. The effect is described as an interplay of stresses generated in bead wake in combination with those generated in the annulus. Conclusion:Bead oscillation based mechanical fragility (MF) profiling of RBC presents a useful tool for exploring effects of different shear stress types for various potential applications for assessment of blood damage, and particularly of sub-hemolytic red cell damage.

show abstract

Low‐stress hemolysis in laminar blood flow: Bulk and surface effects in capillaries

Cited by 14 publications

References 31 publications

Inertia effects and stress accumulation in a constricted duct: A combined experimental and lattice Boltzmann study

Inertia effects and stress accumulation in a constricted duct: A combined experimental and lattice Boltzmann study

Haemolysis induced by mechanical circulatory support devices: unsolved problems

Impact of the Oscillating Bead Size and Shape on Induced Mechanical Stress on Red Blood Cells and Associated Hemolysis in Bead Milling

Contact Info

Product

Resources

About