The combined effect of cyclic thermal shocks and static tensile loading is investigated in 304L stainless steel specimens. Damage obtained at the end of the tests is analyzed by means of experimental observations and dislocation dynamics (DD) simulations. The calculations, carried out using representative loading conditions (σ ZZ = σ θθ ), show that the dominant slip systems do not necessarily have the largest activation ratio. Rather, the dominant slip directions b has specific orientations with respect to the free surface, maximizing the "surface connected volume" (SCV) of the active slip systems. During the tests, a marked effect of the superimposed static tensile loading (or mean stress) is also noted. This effect is also analyzed with the help of DD simulations, performed with a positive mean stress. These calculations show that slip irreversibility in the individual persistent slip bands systematically augments with increasing mean stress.