Low-soluble TREM-like transcript-1 levels early after severe burn reflect increased coagulation disorders and predict 30-day mortality

Lin, Jian-Chang; Xu, Zhaorong; Chen, Zhaohong; Chen, Xiao

doi:10.1016/j.burns.2020.11.016

Cited by 2 publications

(4 citation statements)

References 42 publications

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“…In our multicenter population-based study, D-dimer, a marker reflecting activation of fibrinogenesis, was significantly elevated in the death group and was an independent predictor of survival outcome. Previous investigations have demonstrated that D-dimer levels are elevated upon admission in burn patients 25 . Moreover, early elevation in D-dimer levels in trauma patients is believed to correlate not only with the severity of injury but also to predict multiple adverse outcomes, including hemorrhage, disseminated intravascular coagulation (DIC), and death 31 .…”

Section: Discussionmentioning

confidence: 96%

“…It has been proposed that early changes in severe burns involve the activation of coagulation pathways, a decrease in natural anticoagulants (protein C and protein S), and the initiation of fibrinolysis 1 . Nonetheless, some scholars contend that coagulation experiences heightened activation, leading to microvascular thrombosis subsequent to coagulation dysregulation caused by consumptive coagulation disorders 25 . This results in a state of hypocoagulability and increased fibrinolysis.…”

Section: Discussionmentioning

confidence: 99%

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Identification of early coagulation changes associated with survival outcomes post severe burns from multiple perspectives

Huang,

Ma,

Liao

et al. 2024

Sci Rep

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Coagulation alterations manifest early after severe burns and are closely linked to mortality outcomes. Nevertheless, the precise characterization of coagulation changes associated with early mortality remains elusive. We examined alterations in indicators linked to mortality outcomes at both the transcriptomic and clinical characteristic levels. At the transcriptomic level, we pinpointed 28 differentially expressed coagulation-related genes (DECRGs) following burn injuries and endeavored to validate their causal relationships through Mendelian randomization. DECRGs tied to survival exhibit a significant association with neutrophil function, wherein the expression of CYP4F2 and P2RX1 serves as robust predictors of fatal outcomes. In terms of clinical indicators, early levels of D-dimer and alterations in serum calcium show a strong correlation with mortality outcomes. Coagulation depletion and fibrinolytic activation, stemming from the hyperactivation of coagulation pathways post-severe burns, are strongly linked to patient mortality. Monitoring these early coagulation markers with predictive value can effectively identify individuals necessitating priority critical care.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Identification of early coagulation changes associated with survival outcomes post severe burns from multiple perspectives

Huang,

Ma,

Liao

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In our multicenter population-based study, D-dimer, a marker re ecting activation of brinolysis, was signi cantly elevated in the death group and was an independent predictor of survival outcome. Previous investigations have demonstrated that D-dimer levels are elevated upon admission in burn patients 25 .…”

Section: Discussionmentioning

confidence: 96%

“…It has been proposed that early changes in severe burns involve the activation of coagulation pathways, a decrease in natural anticoagulants (protein C and protein S), and the initiation of brinolysis 1 . Nonetheless, some scholars contend that coagulation experiences heightened activation, leading to microvascular thrombosis subsequent to coagulation dysregulation caused by consumptive coagulation disorders 25 . This results in a state of hypocoagulability and increased brinolysis.…”

Section: Discussionmentioning

confidence: 99%

Early coagulation changes and survival outcomes, a multi-perspective retrospective analysis post severe burn

Huang,

Ma,

Liao

et al. 2024

Preprint

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Coagulation alterations manifest early after severe burns and are closely linked to mortality outcomes. Nevertheless, the precise characterization of coagulation changes associated with early mortality remains elusive. We examined alterations in indicators linked to mortality outcomes at both the transcriptome and clinical characteristic levels. At the transcriptional level, we pinpointed 28 differentially expressed coagulation-related genes (DECRGs) following burn injuries and endeavored to validate their causal relationships through Mendelian randomization. DECRGs tied to survival exhibit a significant association with neutrophil function, wherein the expression of CYP4F2 and P2RX1 serves as robust predictors of fatal outcomes. In terms of clinical indicators, early levels of D-dimer and alterations in serum calcium show a strong correlation with mortality outcomes. Coagulation depletion and fibrinolytic activation, stemming from the hyperactivation of coagulation pathways post-severe burns, are strongly linked to patient mortality. Monitoring these early coagulation markers with predictive value can effectively identify individuals necessitating priority critical care.

show abstract

Low-soluble TREM-like transcript-1 levels early after severe burn reflect increased coagulation disorders and predict 30-day mortality

Cited by 2 publications

References 42 publications

Identification of early coagulation changes associated with survival outcomes post severe burns from multiple perspectives

Identification of early coagulation changes associated with survival outcomes post severe burns from multiple perspectives

Early coagulation changes and survival outcomes, a multi-perspective retrospective analysis post severe burn

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