Low Serum Vitamin D Levels are Associated with Increased Asthma Exacerbations among Children Using Regular Inhaled Corticosteroids

Litonjua, AA; Hollis, Bruce W.; Schuemann, Brooke; Celedon, JC; Fuhlbrigge, Anne L.; Raby, Benjamin A.; Weiss, Scott T.

doi:10.1016/j.jaci.2007.12.1110

Cited by 8 publications

(9 citation statements)

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“…12 Furthermore, Litonjua et al noted that children with insufficient levels of 25(OH)D3 were more likely to have severe exacerbations; however, they did not find any association between the vitamin D levels and bronchodilator response or airway hyper responsiveness. 28 In the present study, the prevalence of vitamin D deficiency was detected in an equatorial population of children with asthma, and lower levels of vitamin D were associated with increased odds of hospitalization for asthma and increased IgE levels; however, there were no associations between the vitamin D levels and eosinophil counts and anti-inflammatory drug use. It has been reported that vitamin D deficiency is highly prevalent even in sunlight-replete areas of the world.…”

Section: Discussioncontrasting

confidence: 55%

“…Based on the categorization of vitamin D levels, 55%, 30%, 10%, and 5% of the asthmatic subjects had serum vitamin D levels of <20 ng/mL (compared with 10% in the control group), 20-30 ng/mL (compared with 20% in the control group), 30-40 ng/mL (compared with 30% in the control group), and ≥40 ng/mL (compared with 40% in the control group; (P = 0.02), respectively, which were statistically significant. Brehm et al 28 found that 25% and 3.4% of asthmatic patients had serum vitamin D levels of <30 and <20 ng/mL, respectively.…”

Section: Discussionmentioning

confidence: 99%

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The relationship between serum vitamin D level and asthma severity in asthmatic children (aged 1 and #8211;15 years) in Ardabil, 2012 and #8211;13

et al. 2015

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

The relationship between serum vitamin D level and asthma severity in asthmatic children (aged 1 and #8211;15 years) in Ardabil, 2012 and #8211;13

et al. 2015

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“…Litonjua et al25 found that children with insufficient levels of 25(OH) D were more likely to have severe exacerbations, but they did not find any association between vitamin D and bronchodilator response or airway hyperresponsiveness. In our study, there were no associations between vitamin D levels and eosinophil counts, course of disease, asthma exacerbation, or anti-inflammatory drug use.…”

Section: Discussionmentioning

confidence: 96%

“…These findings suggest the involvement of vitamin D in lung function and the development of airflow limitation. However, the studies by Brehm et al8 and Litonjua et al25 reported contradictory data. Vitamin D inhibits the formation of matrix metalloproteinase as well as fibroblast proliferation and influences collagen synthesis; these actions mean that 1,25-dihydroxy vitamin D may influence tissue remodeling and probably lung function 26,27.…”

Section: Discussionmentioning

confidence: 98%

The Relationship Between Serum 25 Hydroxy Vitamin D Levels and Asthma in Children

Alyasin

Momen

Kashef

et al. 2011

Allergy Asthma Immunol Res

103

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PurposeAsthma and other allergic disorders have increased over the past decades in nearly all nations. Many studies have suggested the role of vitamin D deficiency in both T-helper1 and T-helper2 diseases; however, the association between vitamin D, allergy, and asthma remains uncertain. In this study, the associations of 25-hydroxy vitamin D3 levels with asthma and with the severity of asthma were evaluated.MethodsThis cross-sectional study was conducted on 50 asthmatic children and 50 healthy controls aged 6-18 years. Serum 25-hydroxy vitamin D3 levels were determined and compared between the two groups. The relationship between serum vitamin D levels and pulmonary function test outcomes and eosinophil counts were examined in asthmatic patients.ResultsUnivariate analysis of the relationship between asthma and vitamin D showed that decreased vitamin D levels were associated with significantly increased odds of asthmatic state (P=0.002). In a multivariate analysis after adjustment for age, body mass index, and sex, the relationship between vitamin D and asthma increased. In asthmatic patients, 25-hydroxy vitamin D levels had direct and significant correlations with both predicted FEV1 (R2=0.318; P=0.024) and FEV1/FVC (R2=0.315; P=0.026). There were no associations between vitamin D level and eosinophil counts, duration of disease, and the number of hospitalization or unscheduled visits in the previous year (P>0.05).ConclusionsThese results showed that serum 25-hydroxy vitamin D levels were inversely associated with asthma, and there was a direct and significant relationship between vitamin D levels and pulmonary function test outcomes in asthmatic children. An interventional study in asthmatic patients with low serum vitamin D concentration may establish a causal relationship between asthma and vitamin D.

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“…Children with vitamin D levels <30 ng/mL were more likely to have severe asthma exacerbations over the course of the 4-year trial (OR = 1.76 [1.01-3.09]) (Litonjua et al, 2008).…”

Section: Exacerbationsmentioning

confidence: 99%

Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis

Zhang¹,

Gong²,

Liu³

2014

Genet. Mol. Res.

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ABSTRACT. Vitamin D deficiency and insufficiency are increasingly being recognized in the general population over the last few decades. However, a number of other disorders have now been linked to vitamin D deficiency and insufficiency, including asthma and COPD. The aim of this study was to evaluate the evidence on the effect of vitamin D on asthma and COPD. We searched electronic databases including SCI, EMBASE, Ovid, and PubMed. Reviewers working independently and in duplicate extracted study characteristics, quality, and the outcomes. The weighted mean differences across trials and random-effect meta-analysis were used to pool the relative risks (RR). This is the first meta-analysis about the risk of vitamin D deficiency for asthma and COPD. Ten studies were available for this meta-analysis and systematic review. The prevalence of vitamin D deficiency was significantly greater among cases than control subjects (65%)]. Moreover, studies failed to demonstrate that COPD patients had an increased risk for vitamin D deficiency or insufficiency compared to controls (RR = 0.89, 95%CI = 0.63-1.25). Vitamin D deficiency was associated with a significant decrease in lung function in asthmatic children. Vitamin D deficiency was highly prevalent in asthma patients, and vitamin D status was associated with lung function. COPD cannot be considered as completely free of vitamin D deficiency.

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Low Serum Vitamin D Levels are Associated with Increased Asthma Exacerbations among Children Using Regular Inhaled Corticosteroids

Cited by 8 publications

References 0 publications

The relationship between serum vitamin D level and asthma severity in asthmatic children (aged 1 and #8211;15 years) in Ardabil, 2012 and #8211;13

The relationship between serum vitamin D level and asthma severity in asthmatic children (aged 1 and #8211;15 years) in Ardabil, 2012 and #8211;13

The Relationship Between Serum 25 Hydroxy Vitamin D Levels and Asthma in Children

Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis

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