Low Serum Vitamin D Concentrations Are Associated with Insulin Resistance in Mexican Children and Adolescents

Denova‐Gutiérrez, Edgar; Muñoz-Aguirre, Paloma; López, Desiree; Flores, Mario; Medeiros-Domingo, Mara; Tamborrel, Natalia; Clark, Patricia

doi:10.3390/nu11092109

Cited by 20 publications

(20 citation statements)

References 26 publications

(30 reference statements)

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“…11 Denova-Gutiérrez et al found an inverse relationship between IR and serum vitamin D levels was observed in 533 Mexican children and adolescents, approximately 90% of whom had sub-optimal vitamin D levels (<30 ng/mL). 12 Our study provides clinicians with a simple method to assess IR and explore the relationship of IR with vitamin D status, suggesting the importance of vitamin D supplementation. Vitamin D deficiency is regarded as a common health problem, which may affect up to half of the general population.…”

Section: Discussionmentioning

confidence: 95%

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Vitamin D Status is Independently Associated with Insulin Resistance in Patients with Type 2 Diabetes Mellitus

Zhao¹,

Tang²,

Zheng

et al. 2021

RMHP

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Purpose This study aimed to examine whether 25-hydroxyvitamin D (25OHD) levels (an indicator of vitamin D status) are independently associated with insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM). Patients and Methods This was a cross-sectional study. Participants with T2DM were recruited from the Department of Endocrinology in Hebei General Hospital according to inclusion and exclusion criteria. Data on basic characteristics and blood parameters were collected. We used the IR index (20/[fasting C-peptide × fasting plasma glucose]) to evaluate IR. Potential confounding factors were selected from comparisons among different IR index groups of quartiles and were adjusted in different models. Results We included 172 subjects (121 men and 51 women) whose mean age was 53.2±10.6 years. Body mass index (BMI), DM course, insulin use, glycated hemoglobin (HbA1c), fasting blood glucose, fasting C-peptide, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (ApoA1), and albumin were differed among different IR-index groups (all P value <0.05). In models 1 and 2, no or some confounding factors were adjusted for, and we found that there was no relationship between 25OHD and the IR index. In model 3, when all confounding factors (DM course, insulin use, BMI, HbA1c, TG, HDL-C, ApoA1, albumin and other bone turnover markers) were adjusted for, the IR index was increased by 5.6% when 25OHD levels increased by 1 ng/mL (odds ratio: 1.056; 95% confidence interval: 1.009, 1.105). Conclusion Vitamin D is independently associated with IR in patients with T2DM.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Vitamin D Status is Independently Associated with Insulin Resistance in Patients with Type 2 Diabetes Mellitus

Zhao¹,

Tang²,

Zheng

et al. 2021

RMHP

View full text Add to dashboard Cite

show abstract

“…The association of vitamin D deficiency with higher body mass index (BMI), insulin resistance (IR), and cardiometabolic risk factors in observational studies with pediatric and young populations has been reported [1][2][3]. Furthermore, previous literature has described a higher prevalence of vitamin D deficiency in children and adolescents with obesity in the pubertal stage compared to prepuberty [4,5].…”

Section: Introductionmentioning

confidence: 99%

The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study

et al. 2021

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Obesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages. A total of 76 children from the PUBMEP study, aged 4–12 years at baseline, were included. Children were evaluated in prepubertal and pubertal stages. Anthropometric measurements and selected cardiometabolic risk biomarkers, such as plasma glucose, blood lipids, insulin, adiponectin, leptin, and blood pressure, and serum 25-hydroxyvitamin D (25(OH)D) were determined. Children were categorized by obesity degree and IR status combined before and after puberty. Paired t-test and multivariate linear regression analyses were conducted. During puberty, the increase in triacylglycerols, insulin, and HOMA-IR and the decrease in QUICKI were significantly associated with the reduction in 25(OH)D (B = −0.274, p = 0.032; B = −0.219, p = 0.019; B = −0.250, p = 0.013; B = 1.574, p = 0.013, respectively) after adjustment by BMI-z, sex, and pubertal stage. Otherwise, prepubertal non-IR children with overweight/obesity that became IR during puberty showed a significant decrease in 25(OH)D and HDL-c, and an increase in waist circumference and triacylglycerol concentrations (p < 0.05 for all) over time. These results suggest that changes in IR seem to be associated with an effect on 25(OH)D levels during puberty, especially in children with overweight.

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“…Animal experiments with labelled vitamin D showed that this vitamin is accumulated in adipose tissue and slowly released to blood [32].Consequently, a vitamin D deficiency in obese children seems to be associated with a significant increase of risk of many metabolic disorders associated with obesity, such as insulin resistance, hyperinsulinemia, impaired tolerance of glucose, abnormal fasting plasma glucose, symptomatic diabetes mellitus, lipid disorders and cardiovascular morbidity, namely arterial hypertension [5,6]. There is a number of observational studies which demonstrate the substantial role of vitamin D deficiency in developing metabolic syndrome and other complications of obesity [33][34][35]. However, we lack interventional studies to link these observations to demonstrate a causal relationship.In this study we wanted to assess the influence of 26 weeks of vitamin D supplementation in overweight and obese children undergoing an integrated 12-months' long weight loss program on body mass reduction, body composition and bone mineral density [36].…”

mentioning

confidence: 99%

“…Consequently, a vitamin D deficiency in obese children seems to be associated with a significant increase of risk of many metabolic disorders associated with obesity, such as insulin resistance, hyperinsulinemia, impaired tolerance of glucose, abnormal fasting plasma glucose, symptomatic diabetes mellitus, lipid disorders and cardiovascular morbidity, namely arterial hypertension [5,6]. There is a number of observational studies which demonstrate the substantial role of vitamin D deficiency in developing metabolic syndrome and other complications of obesity [33][34][35]. However, we lack interventional studies to link these observations to demonstrate a causal relationship.…”

mentioning

confidence: 99%

Long-Term Effects of Vitamin D Supplementation in Obese Children During Integrated Weight–Loss Programme—A Double Blind Randomized Placebo–Controlled Trial

et al. 2020

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Background: Vitamin D was studied in regards to its possible impact on body mass reduction and metabolic changes in adults and children with obesity yet there were no studies assessing the impact of vitamin D supplementation during a weight management program in children and adolescence. The aim of our study was to assess the influence of 26 weeks of vitamin D supplementation in overweight and obese children undergoing an integrated 12-months' long weight loss program on body mass reduction, body composition and bone mineral density. Methods: A double-blind randomized placebo-controlled trial. Vitamin D deficient patients (<30 ng/ml level of vitamin D) aged 6-14, participating in multidisciplinary weight management program were randomly allocated to receiving vitamin D (1200 IU) or placebo for the first 26 weeks of the intervention. Results: Out of the 152 qualified patients, 109 (72%) completed a full cycle of four visits scheduled in the program. There were no difference in the level of BMI (body mass index) change -both raw BMI and BMI centiles. Although the reduction of BMI centiles was greater in the vitamin D vs. placebo group (−4.28 ± 8.43 vs. −2.53 ± 6.10) the difference was not statistically significant (p = 0.319). Similarly the reduction in fat mass-assessed both using bioimpedance and DEXa was achieved, yet the differences between the groups were not statistically significant. Conclusions: Our study ads substantial results to support the thesis on no effect of vitamin D supplementation on body weight reduction in children and adolescents with vitamin D insufficiency undergoing a weight management program.Nutrients 2020, 12, 1093 2 of 15 insulin resistance, hyperinsulinemia, and impaired tolerance of glucose, abnormal fasting plasma glucose, symptomatic diabetes mellitus, lipid disorders and cardiovascular disorders, namely arterial hypertension [4][5][6]. Obesity alone is responsible for a significant increase in the risk of mortality in general population with [7]. In view of high risk of complications resulting from childhood obesity, early implementation of intervention programs seems to be vitally important, as in children and adolescents it is the first-choice intervention, although with limited effectiveness [8]. Several previous studies showed that integrated multidisciplinary weight-loss programs, which include the child's family as well, are the most effective [9][10][11]. Reduction of fat mass is associated with normalization of metabolic parameters, such as inflammatory markers, lipid profile, insulin resistance and arterial blood pressure [12][13][14]. Therefore, early and efficient intervention increases likelihood of staying healthy in the future. As pharmacological and surgical interventions in children are limited [15][16][17], trials looking for substances supporting lifestyle interventions were run, looking at several different dietary supplements, hers (green tea, yerba mate), DHA (docosahexaenoic acid) among others [18][19][20][21][22]. Vitamin D was also studied in regards to its ...

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Low Serum Vitamin D Concentrations Are Associated with Insulin Resistance in Mexican Children and Adolescents

Cited by 20 publications

References 26 publications

Vitamin D Status is Independently Associated with Insulin Resistance in Patients with Type 2 Diabetes Mellitus

Vitamin D Status is Independently Associated with Insulin Resistance in Patients with Type 2 Diabetes Mellitus

The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study

Long-Term Effects of Vitamin D Supplementation in Obese Children During Integrated Weight–Loss Programme—A Double Blind Randomized Placebo–Controlled Trial

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