Low Serum Vitamin B-12 Concentrations Are Prevalent in a Cohort of Pregnant Canadian Women

Visentin, Carly; Masih, Shannon; Plumptre, Lesley; Schroder, Theresa H.; Sohn, Kyoung‐Jin; Ly, Anna; Lausman, Andrea; Berger, Howard; Croxford, Ruth; Lamers, Yvonne; Kim, Young–In; O'Connor, Deborah L

doi:10.3945/jn.115.226845

Cited by 44 publications

(52 citation statements)

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“…In the PREFORM study in Toronto ( n = 368), the prevalence of suboptimal B12 status (serum total B12 <210 pmol/L) was 35% at 12–16 gestational weeks and 43% at delivery, and the prevalence of B12 deficiency (serum total B12 <148 pmol/L) was 17% and 38%, respectively [12]. In Vancouver, the prevalence of suboptimal B12 status and B12 deficiency was 21% and 10% in 264 women at 16 gestational weeks, and 35% and 23% in 220 women at delivery, respectively [13]; plasma MMA concentration was not measured in the study by Wu et al [13].…”

Section: Discussionmentioning

confidence: 99%

“…In Vancouver, the prevalence of suboptimal B12 status and B12 deficiency was 21% and 10% in 264 women at 16 gestational weeks, and 35% and 23% in 220 women at delivery, respectively [13]; plasma MMA concentration was not measured in the study by Wu et al [13]. In the PREFORM study, plasma MMA concentration was measured and the prevalence of functional B12 deficiency (defined as MMA >271 nmol/L) was two percent in early pregnancy and five percent at delivery [12]. In the present study, 26 (eight percent) of second- and third-trimester pregnant women had plasma MMA concentration >270 nmol/L.…”

Section: Discussionmentioning

confidence: 99%

“…We measured total B12, the most commonly used biomarker and direct indicator, and MMA, the more specific functional indicator of B12 deficiency compared to total homocysteine. The additional measurement of total homocysteine might not have allowed further insight to the B12 status of these women; in Canada, a folate-replete nation, elevated total homocysteine concentrations (defined as >13 µmol/L [22,42]) was observed in five percent of the general population [10] but not in pregnant Canadian women [12]. While MMA is considered the more specific indicator of B12 status, we acknowledge that MMA is influenced by renal function [43] and we lack the measurement of creatinine to control for renal function in the interpretation of elevated MMA concentration.…”

Section: Discussionmentioning

confidence: 99%

“…We previously reported a 20% prevalence of suboptimal B12 status and 14% B12 deficiency in a convenience sample of 206 reproductive-aged women of South Asian and European ethnicity living in Metro Vancouver, with a non-significant trend for a higher prevalence of B12 deficiency in South Asian women [11]. Results of two recent prospective cohort studies of pregnant Canadian women revealed a high prevalence of low B12 status in pregnancy, with deficiency as high as 38% at delivery [12,13]. …”

Section: Introductionmentioning

confidence: 99%

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South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women

et al. 2017

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Vitamin B12 (B12) adequacy during pregnancy is crucial for maternal health and optimal fetal development; however, suboptimal B12 status has been reported in pregnant Canadian women. Methylmalonic acid (MMA) is a sensitive indicator of B12 status. Since few studies have measured MMA during pregnancy in Canadian women, the objective of this study was to evaluate B12 status in pregnant women living in Metro Vancouver, using both plasma total B12 and MMA. We recruited a convenience sample of 320 pregnant women between 20 and 35 gestational weeks from local healthcare facilities. Plasma total B12 concentrations indicative of deficiency (<148 pmol/L) and suboptimal B12 status (148–220 pmol/L) were found in 18% and 33% of the women, respectively. Normal plasma MMA concentration (<210 nmol/L) was observed in 82% of all women. Gestational age was a strong predictor of plasma total B12 and MMA concentration, and South Asian ethnicity of B-12 deficiency and MMA concentrations. Overall, there was a high discrepancy between the prevalence of B12 inadequacy depending on the biomarker used. Independently, however, South Asian women were at particular risk for B12 deficiency, likely due to lower animal source food intake. Further study of this vulnerable group and performance testing of B12 biomarkers is warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women

et al. 2017

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“…In contrast, no folate deficiency was found in this population 13 . The highest risk of vit B12 deficiency would be in vegetarian women 27 because the major source of this vitamin is found in meat products. In Chile, only the prevalence of vit B12 deficiency in older adults is estimated to be in the range of 25.4 to 54.1% 28 .…”

Section: Interaction Between Folates and Vit B12 -Folate Trappingmentioning

confidence: 99%

Folatos y Embarazo, conceptos actuales: ¿Es necesaria una suplementación con Acido Fólico?

Castaño

Piñuñuri

Hirsch

et al. 2017

Rev. chil. pediatr.

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Folate intake during pregnancy is essential for an adequate fetal and placental development and for the long time health of the individual. Its deficiency may induce fetal pathologies, including neural tube disease (NTD). Therefore, several countries implemented public policies to fortify foods with folic acid (FA). Chile started the fortification of wheat flour with FA in the year 2000, decreasing a 43% the prevalence of NTD. However, despite the high consumption of bread (the main fortified food with FA) by our population, a high number of pregnant women consume FA supplements, thus, over passing the maximal recommended FA intake. Additionally, if the diet is reduced in vitamin B12, the optimal ratio folates/vit B12 may be altered, thus inducing changes in the methylation of specific genes and other metabolic pathways, affecting fetal development and the long-term health of the neonates. We think that, after 16 years of the initiation of the fortification of wheat flour with FA, it is necessary to evaluate the possible side effects of a high intake of FA in the pregnant population and their offspring. This article shows antecedents about mechanisms of folates and vit B12 at cellular level, and their possible consequences of an elevated FA maternal intake on the offspring.

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Diet and human reproductive system: Insight of omics approaches

Wang

et al. 2022

Food Science & Nutrition

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Nutrition and lifestyle have a great impact on reproduction and infertility in humans, as they are essential for certain processes such as implantation, placental growth, angiogenesis, and the transfer of nutrients from the mother to the fetus. The aim of this review is to provide the interconnection between nutrition and reproductive health through the insight of omics approaches (including metabolomics and nutrigenomics). The effect of various macronutrients, micronutrients, and some food‐associated components on male and female reproduction was discussed. Recent research work was collected through database search from 2010 to 2020 to identify eligible studies. Alterations of metabolic pathways in pregnant women were deliberated with an emphasis on different strategies of lifestyle and dietary interventions. Several nutritional methods, which are important for embryonic and child neurological development, nutritional supplements to lactation, and improved gestational length along with birth weight have been emphasized. Considerable advances in omics strategies show potential technological development for improving human reproductive health.

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Low Serum Vitamin B-12 Concentrations Are Prevalent in a Cohort of Pregnant Canadian Women

Cited by 44 publications

References 50 publications

South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women

South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women

Folatos y Embarazo, conceptos actuales: ¿Es necesaria una suplementación con Acido Fólico?

Diet and human reproductive system: Insight of omics approaches

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