Low serum total bilirubin concentrations are associated with increased prevalence of metabolic syndrome in Chinese

Wu, Yeke; Li, Mian; Xu, Min; Bi, Yufang; Li, Xiaoying; Chen, Yuhong; Ning, Guang; Wang, Weiqing

doi:10.1111/j.1753-0407.2011.00138.x

Cited by 77 publications

(73 citation statements)

References 21 publications

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“…Furthermore, our results showed that the duration of diabetes is independently and inversely associated with the physiological serum bilirubin concentration, suggesting that the serum bilirubin level, with its associated antioxidant properties, declines with an increasing duration of diabetes after the development of type 2 diabetes. Smoking is also associated with a decreased serum bilirubin level (19), and several clinical studies have reported that the serum bilirubin level is associated with the prevalence of hypertension, HbA1c, and dyslipidemia (18,20,21). In the present study, the serum bilirubin level was also found to be associated with age, smoking habits, HbA1c, the lipid profile and hypertension.…”

Section: Discussionsupporting

confidence: 65%

The Duration of Diabetes is Inversely Associated with the Physiological Serum Bilirubin Levels in Patients with Type 2 Diabetes

et al. 2015

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Objective The aim of this study was to assess the relationship between the duration of diabetes and the physiological serum bilirubin concentration in association with antioxidant properties in patients with type 2 diabetes. Methods A total of 1,746 patients with type 2 diabetes were investigated in this cross-sectional study. An analysis of covariance was performed after adjusting for other covariates. Simple correlation analyses and a multivariate regression model were used to assess the association between the duration of diabetes and the serum bilirubin concentration. Results The mean total bilirubin value differed significantly according to the tertile of diabetes duration (<5 years, 12.38 μmol/L, 95% confidence interval (CI) 12.02-12.76; 5-11.9 years, 12.33 μmol/L, 95% CI 11.97-12.69 ! 12 years, 11.73 μmol/L, 95% CI 11.35-12.11; p for trend =0.033), after adjustment for other covariates. In addition, an inverse correlation was found between the serum bilirubin concentration and diabetes duration (ρ=-0.211, p<0.001). According to a multivariate model, the association between the diabetes duration and serum bilirubin concentration remained significant, even after adjustment for confounding factors (β=-0.074, p=0.008). Conclusion The duration of diabetes is inversely associated with a serum bilirubin concentration within the physiologic range in patients with type 2 diabetes.

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Section: Discussionsupporting

confidence: 65%

The Duration of Diabetes is Inversely Associated with the Physiological Serum Bilirubin Levels in Patients with Type 2 Diabetes

et al. 2015

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“…Numerous reports have found that moderate alcohol intake is associated with selected favorable health outcomes (Di Giuseppe et al, 2012; Doll et al, 2005; Freiberg et al, 2004; Mukamal et al, 2003; Rehm et al, 2003; Ronksley et al, 2011), although the mechanism for these benefits is still not understood (Carnevale and Nocella, 2012). At the same time, another line of research has indicated that higher concentrations (but still well within accepted reference ranges) of serum bilirubin, a powerful antioxidant (Rizzo et al, 2010; Stocker et al, 1987), correlate with better health outcomes or conversely lower bilirubin concentrations with higher morbidities (Cheriyath et al, 2010; Curtin and Fairchild, 2003; Fischman et al, 2010; Horsfall et al, 2011; Novotny and Vitek, 2003; Perlstein et al, 2008; Rigato et al, 2005; Vitek and Schwertner, 2008; Wu et al, 2011). Of note, any drinking has been reported to be associated with higher, but still within the reference range, concentrations of serum bilirubin as compared to abstainers (Tanaka et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Bilirubin concentrations, in turn, have also been inversely associated with risk for cardiovascular disease (Novotny and Vitek, 2003; Perlstein et al, 2008; Vitek and Schwertner, 2008), metabolic syndrome (Wu et al, 2011), inflammatory disease (Fischman et al, 2010), diabetes (Cheriyath et al, 2010), and some cancers (Horsfall et al, 2011). Unconjugated (indirect) bilirubin, the primary form of bilirubin circulating in healthy individuals, has antioxidant properties (Rizzo et al, 2010; Stocker et al, 1987), which have been suggested as possible mechanisms for its apparent protective effects.…”

Section: Introductionmentioning

confidence: 99%

Acute alcohol consumption elevates serum bilirubin: An endogenous antioxidant

O’Malley

Gueorguieva²,

et al. 2015

Drug and Alcohol Dependence

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Background Moderate alcohol consumption has been associated with both negative and favorable effects on health. The mechanisms responsible for reported favorable effects remain unclear. Higher (not necessarily elevated) concentrations of serum bilirubin, an antioxidant, have also been associated with reduced risk of cardiovascular disease and all-cause mortality. This study tests the hypothesis that single dose alcohol consumption elevates bilirubin providing a potential link between these observations. Methods 18 healthy individuals (8 cigarette smokers) were administered alcohol, calibrated to achieve blood concentrations of 20, 80 and 120 mg/dL, in random order in 3 laboratory sessions separated by a week. Each session was preceded by and followed by 5–7 days of alcohol abstinence. Serum bilirubin was measured at 7:45 am prior to drinking, at 2 pm, and at 7:45 the next morning. Mixed effects regression models compared baseline and 24 hr. post-drinking bilirubin concentrations. Results Total serum bilirubin (sum of indirect and direct) concentration increased significantly after drinking from baseline to 24 hours in non-smokers (from Mean=0.38, SD=0.24 to Mean=0.51 SD=0.30, F(1, 32.2) =24.24, p<.0001) but not in smokers (from Mean=0.25, SD=0.12 to Mean=0.26, SD=0.15, F(1, 31.1) =0.04, p=0.84). In nonsmokers the indirect bilirubin concentration and the ratio of indirect (unconjugated) to direct (conjugated) bilirubin also increased significantly. Conclusions Alcohol consumption leads to increases in serum bilirubin in nonsmokers. Considering the antioxidant properties of bilirubin, our findings suggest one possible mechanism for the reported association between alcohol consumption and reduced risk of some disorders that could be tested in future longitudinal studies.

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“…While, in adults serum bilirubin may present potential beneficial effects in preventing oxidative changes (Stocker et al 1987) as scavengers of lipid peroxyl radicals and human LDL against lipid peroxidation (Wu et al 1994;Yamaguchi et al 1996). Epidemiological studies have generally suggested that high bilirubin levels are associated with a reduced risk of metabolic syndrome (Wu et al 2011) and cardiovascular disease (CVD) (Novotný and Vítek 2003;McArdle et al 2012), and therefore against the development of vascular disease.…”

Section: Introductionmentioning

confidence: 99%

Handgrip Strength Is Positively Associated with Mildly Elevated Serum Bilirubin Levels among Community-Dwelling Adults

Kawamoto

Ninomiya

Kumagi

2016

Tohoku J. Exp. Med.

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Handgrip strength (HGS) is a useful measure of health-related quality of life and general muscle strength. Serum total bilirubin (T-B) may present potential beneficial effects in preventing oxidative changes which are associated with a risk of metabolic syndrome and the development of cardiovascular disease. Limited information is available regarding whether HGS is an independent confounding factor for serum T-B. The study participants were 214 men aged 71 ± 8 (mean ± standard deviation) years and 302 women aged 71 ± 7 years that were enrolled consecutively from among paticipants aged ≥ 50 years through an annual check-up process. We evaluated the relationship between serum T-B and confounding factors within each sex. HGS related significantly with serum T-B in both men (r = 0.156, p = 0.023) and women (r = 0.173, p = 0.003). Multiple linear regression analysis showed that in men, HGS (β = 0.173) as well as smoking status (β = −0.147), exercise habit (β = 0.138), low-density lipoprotein cholesterol (β = 0.146), and hemoglobin A1c (HbA1c) (β = −0.198) were significantly and independently associated with serum T-B. In women, HGS (β = 0.159) as well as smoking status (β = −0.116), high-density lipoprotein cholesterol (β = 0.159), and HbA1c (β = −0.161) were significantly and independently associated with serum T-B. Multivariateadjusted serum T-B levels were significantly lower in subjects with the lowest HGS level in both sexes. Increased HGS is strongly associated with increased serum T-B, independent of confounding factors in both sexes.

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Low serum total bilirubin concentrations are associated with increased prevalence of metabolic syndrome in Chinese

Abstract: Serum TBil concentrations within the physiological range were inversely associated with MS and insulin resistance, hyperinsulinemia, and systemic inflammation in middle-aged and elderly Chinese.

Cited by 77 publications

References 21 publications

The Duration of Diabetes is Inversely Associated with the Physiological Serum Bilirubin Levels in Patients with Type 2 Diabetes

The Duration of Diabetes is Inversely Associated with the Physiological Serum Bilirubin Levels in Patients with Type 2 Diabetes

Acute alcohol consumption elevates serum bilirubin: An endogenous antioxidant

Handgrip Strength Is Positively Associated with Mildly Elevated Serum Bilirubin Levels among Community-Dwelling Adults

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