Low serum paraoxonase: a risk factor for atherosclerotic disease?

Oxidative stress during early pregnancy and birth outcomes

“…It therefore has a protective role against cellular damage from oxidative stress (22) and low serum PON-1 activity is associated with increased risk of atherosclerosis (7,23) as well as adverse birth outcomes (10,21) . The activity of PON-1 in T1 was significantly lower among women who delivered LBW babies (Table 3).…”

Paraoxonase 1 gene polymorphisms contribute to coronary artery disease risk among north Indians

“…[24,26] P O N 1 p r o t e i n p l a y s a k e y r o l e i n organophosphate metabolism (widely used in insecticides and nerve gases); however, PON1 has been linked to lipid metabolism also. [34] The link between PON1 activity and atherosclerosis is largely established by biological rather than epidemiological studies, as there is evidence that peroxidation of low-density lipoprotein cholesterol (LDL-C) is an important risk factor for atherosclerosis. [34][35][36][37][38][39][40] As oxidative damage is a major contributor to arteriolosclerosis, the oxidative modiÞ cation of LDL in the artery wall is an important factor in the development of CAD.…”

Decreased Atherosclerotic Lesion Formation in Human Serum Paraoxonase Transgenic Mice

“…6,7 PON1 was initially identified for its ability to hydrolyze organophosphate insecticides. 8 More recently, PON1 has been shown to prevent LDL oxidation in vitro, 9,10 and decreased levels of PON1 are associated with an increased risk of cardiovascular disease. 10 -12 In studies with PON1 knockout (KO) mice, PON1 has been shown to be both necessary and sufficient for the in vitro protective effects of HDL on LDL oxidation and monocyte transmigration.…”