Low serum pancreatic enzyme levels predict mortality and are associated with malnutrition–inflammation–atherosclerosis syndrome in patients with chronic kidney disease

Abstract

Serum amylase activity was found to be an independent predictor of mortality in ESRD patients. Relatively low serum pancreatic enzyme levels in CKD may be regarded as a novel component of the malnutrition-inflammation-atherosclerosis syndrome.

Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer

“…Elevated levels of pancreatic lipases also occur in bowel obstruction or kidney disease (47, 48). On the other hand, individuals with Crohn's disease, cystic fibrosis, and celiac disease suffer from lipase deficiency, in which the cells of the pancreas responsible for producing this enzyme may be irreversibly damaged (49).…”

Low lipase levels as an independent marker of pancreatic cancer: a frequently neglected condition in clinical setting

“…These pancreatic enzymes may also increase in a number of conditions, including in non-malignant hepatobiliary and gastrointestinal diseases, pulmonary failure, sepsis, subdural bleeding, renal failure, and pancreatic cancer (4,(6)(7)(8)(9)(10). Low levels of pancreatic enzymes, on the other hand, particularly serum lipase, have rarely been addressed or associated with clinical conditions (4,11). In fact, mostly a lower limit is not usually defined for lipase levels, where a value close to zero is considered normal.…”

Low serum amylase, lipase, and trypsin as biomarkers of metabolic disorders: A systematic review and meta-analysis

“…Fifth, kidney (dys)function and concomitant therapy might have affected the studied associations. Unfortunately, only one study [25] provided detailed information on this aspect. Sixth, only 5 out of the 20 included studies were of high methodological quality (as evidenced by the Newcastle-Ottawa score of 7 or above).…”

“…Fourteen of them were excluded and 20 studies were finally included in the systematic review ( Fig. 1) [5,8,[20][21][22][23][24][25][26][27][28][29][9][10][11][12][16][17][18][19]. A total of 20,916 individuals participated in the 20 included studies.…”

“…The methodological quality of the included studies is presented in Table 1. Twelve studies (encompassing 6517 individuals) were suitable for meta-analysis [5,9,27,29,10,11,[16][17][18]22,25,26]. Serum amylase was investigated in 12 studies, serum lipase -five studies, and serum trypsin -three studies (Table 1).…”