Low Serum Oxytocin Concentrations Are Associated with Painful Menstruation

Oladosu, Folabomi A.; Tu, Frank F.; Garfield, Lindsey; Garrison, Ellen F.; Steiner, Nicole; Roth, Genevieve E.; Hellman, Kevin M.

doi:10.1007/s43032-019-00071-y

Cited by 12 publications

(11 citation statements)

References 40 publications

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“…When suckling stimulus declines near weanling, preovulatory LH surge restores and ovulation takes place with the formation of a corpus luteum of variable normality. By contrast, women with a history of primary or secondary dysmenorrhea have lower blood OT concentrations during menses, which is associated with worse menstrual pain and pain-related behavior (61). In women with early life sexual abuse, OT can positively modulate menstruation-related mood disorders (109).…”

Section: Ot Functions At Different Reproductive Stages Of Women 41 Me...mentioning

confidence: 99%

“…Sexual dimorphism of OT functions is based on expression levels of OT and OTRs. For instance, serum OT levels are significantly higher among women than men ( 60 ), which makes women more sensitive to OT level reduction and likely accounts for menstrual pain ( 61 ) and higher incidence of depression in women ( 62 ). By contrast, OT binding sites in the VMH and dorsal horns are significantly high in males relative to females ( 63 ), which may contribute to the central regulatory actions of OT on feeding, reproduction via VMH ( 64 ) and nociception via the spinal cord ( 65 ).…”

Section: Ot Functions and Sexual Dimorphismmentioning

confidence: 99%

“…By contrast, women with a history of primary or secondary dysmenorrhea have lower blood OT concentrations during menses, which is associated with worse menstrual pain and pain-related behavior ( 61 ). In women with early life sexual abuse, OT can positively modulate menstruation-related mood disorders ( 109 ).…”

Section: Ot Functions At Different Reproductive Stages Of Womenmentioning

confidence: 99%

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Oxytocin in Women’s Health and Disease

et al. 2022

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Oxytocin (OT) is a nonapeptide mainly produced in the supraoptic and paraventricular nuclei. OT in the brain and blood has extensive functions in both mental and physical activities. These functions are mediated by OT receptors (OTRs) that are distributed in a broad spectrum of tissues with dramatic sexual dimorphism. In both sexes, OT generally facilitates social cognition and behaviors, facilitates parental behavior and sexual activity and inhibits feeding and pain perception. However, there are significant differences in OT levels and distribution of OTRs in men from women. Thus, many OT functions in men are different from women, particularly in the reproduction. In men, the reproductive functions are relatively simple. In women, the reproductive functions involve menstrual cycle, pregnancy, parturition, lactation, and menopause. These functions make OT regulation of women’s health and disease a unique topic of physiological and pathological studies. In menstruation, pre-ovulatory increase in OT secretion in the hypothalamus and the ovary can promote the secretion of gonadotropin-releasing hormone and facilitate ovulation. During pregnancy, increased OT synthesis and preterm release endow OT system the ability to promote maternal behavior and lactation. In parturition, cervix expansion-elicited pulse OT secretion and uterine OT release accelerate the expelling of fetus and reduce postpartum hemorrhage. During lactation, intermittent pulsatile OT secretion is necessary for the milk-ejection reflex and maternal behavior. Disorders in OT secretion can account for maternal depression and hypogalactia. In menopause, the reduction of OT secretion accounts for many menopausal symptoms and diseases. These issues are reviewed in this work.

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Section: Ot Functions At Different Reproductive Stages Of Women 41 Me...mentioning

confidence: 99%

Section: Ot Functions and Sexual Dimorphismmentioning

confidence: 99%

Section: Ot Functions At Different Reproductive Stages Of Womenmentioning

confidence: 99%

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Oxytocin in Women’s Health and Disease

et al. 2022

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“…Oxytocin is often referred to as the 'feel-good' hormone or as an indicator of positive emotions (Mitsui et al, 2011). In addition, oxytocin has analgesic effects (Xin et al, 2017), with lower oxytocin concentrations in humans in pain (Oladosu et al, 2020). However, oxytocin regulation and its effects remain poorly understood (Rault et al, 2017) and further studies are warranted.…”

Section: Table 4amentioning

confidence: 99%

Novel saliva biomarkers for stress and infection in pigs: Changes in oxytocin and procalcitonin in pigs with tail-biting lesions

Valros

López-Martínez

Munsterhjelm

et al. 2022

Research in Veterinary Science

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“…No obstante, la multiparidad, procedimientos quirúrgicos cervicales previos o la infección pueden dar lugar a alteraciones de las características morfológicas del cuello uterino (27) . De igual forma, los factores que probablemente afectan a los resultados de los índices de Doppler de potencia tridimensional son: presión ejercida por el transductor sobre el tejido cervical durante la evaluación, contracciones uterinas que tienen efectos sobre la velocidad del flujo sanguíneo y cambios fisiológicos en la circulación sanguínea del cuello uterino durante la exploración (28,29) . Además, existen otros factores técnicos importantes, como si el ángulo de insonación de las ondas de ultrasonido.…”

Section: Puntounclassified

Índices de vascularización cervical en la predicción de parto pretérmino inminente

Mejia-Montilla¹,

Reyna-Villasmil²,

Torres-Cepeda³

et al. 2022

Rev peru ginecol obstet.

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Objetivo. Establecer la utilidad de los índices de vascularización cervical en la predicción de parto pretérmino inminente. Diseño. Estudio de casos-controles. Institución. Hospital Central “Dr. Urquinaona”, Maracaibo, Venezuela. Participantes. Pacientes con parto pretérmino en los siguientes 7 días (grupo A) y embarazadas con parto pretérmino más allá de los 7 días (grupo B). Métodos. Las embarazadas fueron evaluadas utilizando ecografía transvaginal y seguidas hasta el parto. Principales medidas de resultado. Características generales, índices de vascularización cervical (índice de vascularización, índice de flujo e índice de vascularización / flujo), parto pretérmino inminente y eficacia pronóstica. Resultados. Fueron incluidas 350 pacientes, 75 mujeres presentaron parto pretérmino inminente (grupo A) y 251 pacientes fueron consideradas como controles (grupo B). Las pacientes del grupo A tuvieron valores significativamente más bajos del índice de vascularización e índice de flujo comparado con el grupo B (p = 0,0122 y p < 0,0001, respectivamente). Las pacientes del grupo B presentaron valores significativamente más altos de índice de vascularización / flujo comparadas con las pacientes del grupo A (p = 0,0103). Los tres índices y la combinación de estos no mostraron capacidad de discriminación de parto pretérmino inminente. Conclusiones. Las pacientes con parto pretérmino inminente presentan diferencias significativas en los índices de vascularización comparado con las pacientes que presentan parto pretérmino más allá de los 7 días de la evaluación ecográfica. Sin embargo, no son útiles en la predicción del parto pretérmino inminente.

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Low Serum Oxytocin Concentrations Are Associated with Painful Menstruation

Cited by 12 publications

References 40 publications

Oxytocin in Women’s Health and Disease

Oxytocin in Women’s Health and Disease

Novel saliva biomarkers for stress and infection in pigs: Changes in oxytocin and procalcitonin in pigs with tail-biting lesions

Índices de vascularización cervical en la predicción de parto pretérmino inminente

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