Low serum osteocalcin level is a potential marker for metabolic syndrome: results from a Chinese male population survey

Tan, Aihua; Gao, Yong; Yang, Xiaobo; Zhang, Haiying; Qin, Xue; Mo, Linjian; Peng, Tao; Xia, Ning; Mo, Zengnan

doi:10.1016/j.metabol.2011.01.002

Cited by 101 publications

(100 citation statements)

References 24 publications

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“…Only a study conducted in younger Chinese men (mean age of 40 years) showed a doseresponse relationship between MetS severity and serum osteocalcin levels. Participants with lower quartiles of serum osteocalcin had higher risk of more severe MetS (16). These results are consistent with our results.…”

Section: European Journal Of Endocrinologysupporting

confidence: 93%

“…Interestingly, even if osteocalcin is implicated in the regulation of male fertility through the secretion of testosterone (12,32), it seems that the action of osteocalcin on glucose metabolism and MetS is conserved and observed in both genders (14,31,33,34). Furthermore, in addition to the study of Yeap (15) and to our work on a Caucasian population, research has also been conducted on other ethnic groups including Blacks (14), Chinese (16,17), and Koreans (33), suggesting that osteocalcin metabolic functions initially discovered in rodents (9,11,35,36) are conserved in humans and across ethnic groups. Lastly, a causal relationship in humans has been recently reported with the finding of MetS and primary testicular failure in patients with a genetic dominant-negative mutation of the osteocalcin receptor (GPRC6A) (32).…”

Section: European Journal Of Endocrinologymentioning

confidence: 85%

“…Nevertheless, data concerning MetS severity are scarce. One study was conducted in a population of young Chinese (16) and another one in a Chinese cohort at high cardiovascular risk (17). To our knowledge, there are no data on the link between osteocalcin level and MetS severity in Caucasian men.…”

Section: Introductionmentioning

confidence: 99%

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Lower serum osteocalcin is associated with more severe metabolic syndrome in elderly men from the MINOS cohort

Confavreux¹,

Szulc²,

Casey³

et al. 2014

European Journal of Endocrinology

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Background: Bone has emerged as an endocrine organ regulating energy metabolism through secretion of osteocalcin. In epidemiological studies, presence of metabolic syndrome (MetS) was associated with lower osteocalcin level. Objectives: We evaluated whether osteocalcin level was associated with MetS severity in men and whether it was more strongly associated with MetS compared with N-terminal propeptide of type I procollagen (PINP), bone-specific alkaline phosphatase (BAP), and C-terminal telopeptide of type I collagen (bCTX). Methods: We included 798 men aged 51-85 years for total osteocalcin measurement. Number of MetS criteria was used to define severity. We used polytomous logistic regression to assess the relationship between MetS severity and osteocalcin level. Results: Thirty percent of men had MetS. In patients with MetS, the higher the number of MetS traits were present, the lower was the average osteocalcin level (0-2 criteria: 551 men: 19.5G6.7 ng/ml, three criteria: 155 men: 19.3G7.4 ng/ml, four criteria: 72 men: 17.3G5.7 ng/ml, and five criteria: 20 men: 15.0G5.1 ng/ml; P for trendZ0.002). In the polytomous logistic regression model, an increase in osteocalcin level of 10 ng/ml was associated with lower prevalence of severe MetS: three criteria (odds ratio (OR)Z0.93 (0.70-1.24)), four criteria (ORZ0.54 (0.34-0.84)), and five criteria (ORZ0.28 (0.10-0.82)) in comparison with no MetS (P for trendZ0.008). After adjustment, using stepwise analysis of the polytomous logistic regression model, we observed that osteocalcin, age, and apparent free testosterone entered in the model but not other bone markers (PINP, bCTX, and BAP). Conclusion: In older Caucasian men, total osteocalcin level was associated with MetS severity. Osteocalcin was more strongly associated with MetS severity than other bone turnover markers.

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Section: European Journal Of Endocrinologysupporting

confidence: 93%

Section: European Journal Of Endocrinologymentioning

confidence: 85%

See 1 more Smart Citation

Lower serum osteocalcin is associated with more severe metabolic syndrome in elderly men from the MINOS cohort

Confavreux¹,

Szulc²,

Casey³

et al. 2014

European Journal of Endocrinology

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“…They were unrelated healthy Chinese males aged 20-69 years from the FAMHES, which has been described elsewhere. 35 The stage 2 was conducted with 1496 healthy Chinese men aged 20-69 years. They were randomly chosen from the men who participated in physical examinations from September 2009 to September 2010 in the Medical Centre of Fangchenggang First People's Hospital, Guigang People's Hospital and Yulin First People's Hospital.…”

Section: Study Populationmentioning

confidence: 99%

“…Respondents that reported smoking currently (daily smoking 46 moths) were coded as smokers, and those reported drinking any beverage 'more than once a year' were coded as drinkers, whereas others were nondrinkers. 18,35 Our study research protocol was approved by the local Ethics Committee and Informed consent of each participant was obtained with written documentation. …”

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confidence: 99%

Genome-wide association study identifies common variants at TNFRSF13B associated with IgG level in a healthy Chinese male population

Liao

Zhang

et al. 2012

Genes Immun

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IgG has a crucial role in humoral immune response. Serum IgG level is mainly determined under genetic control. To explore the genetic influence on serum IgG levels, a two-stage genome-wide association study (GWAS) was performed in a healthy Chinese population of 3495 men, including 1999 unrelated subjects in the first stage and 1496 independent individuals in the second stage. Three single-nucleotide polymorphisms (SNPs) located in TNFRSF13B on 17p11.2 or nearby were significantly associated with IgG level: rs4792800 in the intron (combined P-value ¼ 1.45 Â 10 À 12 ), rs12603708 in the intron (combined P-value ¼ 1.82 Â 10 À 8 ) and rs3751987 at B65 kb downstream of the 5 0 -UTR region of TNFRSF13B (combined P-value ¼ 3.67 Â 10 À 9 ). Additionally, smoking was identified to be associated with IgG level in both stages (Po0.001), but there was no significant interaction between smoking and the identified SNPs (P40.05). The strong association between variants at TNFRSF13B and IgG level may be helpful to further explore the biological mechanism by which the serum IgG is affected by transmembrane activator, calcium modulator and cyclophilin ligand interactor encoded by TNFRSF13B.Genes and Immunity (2012) 13, 509-513; doi:10.1038/gene.2012.26; published online 7 June 2012Keywords: IgG; genome-wide association studies; TNFRSF13B; TACI; smoking INTRODUCTION IgG, constituting some 80% of total serum immunoglobulin, is the most abundant class of antibodies (Ab) in serum and extracellular fluid. It has an important role in the defense against various pathogens, toxins and even cancers. 1 As the only isotype that can pass through the human placenta, IgG is able to protect the fetus in utero. 2 Meanwhile, IgG gets involved in chronic inflammatory processes contributed to the destruction of healthy tissues in autoimmune diseases, such as arthritis and systemic lupus erythematosus. 3 Serum IgG level varies considerably from one person to another, 4 but little when testing the same person repeatedly. 5 This variation in the serum IgG concentration reflects the balance among the rates of synthesis and catabolism. 6 Multitudinous environmental factors including infections, smoking and chemical compounds can contribute to this variation. 7-9 Reports of pedigree studies or twin studies 10,11 have shown that genetic factors are more important than environmental exposures in determining serum immunoglobulin level in human. 12,13 The values of genetic heritability was h 2 ¼ 0.617 þ 0.020 for IgG. 6 Besides, several studies in a population of common variable immunodeficiency patients or IgA deficiency patients implied that there might be an association between some gene loci and serum IgG level. 14,15 However, to the best of our knowledge, no study has ever been conducted to identify the immune loci directly involved in the regulation of the IgG level.Genome-wide association study (GWAS) is a powerful and unbiased tool for the identification of common genetic variants associated with complex traits. 16 This hypothesis-free approach base...

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Both total testosterone and sex hormone‐binding globulin are independent risk factors for metabolic syndrome: results from Fangchenggang Area Male Health and Examination Survey in China

Zhang

Huang

Liao

et al. 2013

Diabetes Metabolism Res

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Low serum osteocalcin level is a potential marker for metabolic syndrome: results from a Chinese male population survey

Cited by 101 publications

References 24 publications

Lower serum osteocalcin is associated with more severe metabolic syndrome in elderly men from the MINOS cohort

Lower serum osteocalcin is associated with more severe metabolic syndrome in elderly men from the MINOS cohort

Genome-wide association study identifies common variants at TNFRSF13B associated with IgG level in a healthy Chinese male population

Both total testosterone and sex hormone‐binding globulin are independent risk factors for metabolic syndrome: results from Fangchenggang Area Male Health and Examination Survey in China

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