Low serum miR-98 as an unfavorable prognostic biomarker in patients with non-small cell lung cancer

Wang, Kaichao; Dong, Liyuan; Fang, Qinmu; Xiao, Hong‐Wei; Hou, Xinlei

doi:10.3233/cbm-170124

Cited by 19 publications

(20 citation statements)

References 19 publications

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“…Increasingly, studies are indicting that miRNAs may be key regulators in the initiation and progression of human cancers (15)(16)(17). For NSCLC, various miRNAs has been demonstrated to be aberrantly expressed, including miR-98 (18), miR-373 (19), miR-484 (20) and miR-1258 (21). The dysregulation of miRNAs may have tumor-suppressing or oncogenic roles in NSCLC, and thus serve crucial roles in the genesis and development of NSCLC by regulating multiple cellular biological processes (22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

miR‑802 inhibits the aggressive behaviors of non‑small cell lung cancer cells by directly targeting FGFR1

Zhang

et al. 2019

Int J Oncol

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Emerging reports have revealed that several microRNAs (miRNAs) are abnormally expressed in non-small cell lung cancer (NSCLC). miRNAs have been identified as oncogenes or tumor suppressors, and regulate various biological processes including oncogenesis and development. miR-802 is dysregulated in multiple types of human cancer, and exerts tumor-suppressive or promoting roles. However, the expression levels and functional roles of miR-802 in NSCLC remain largely unknown. In the present study, miR-802 expression was demonstrated to be decreased in NSCLC tissues and cell lines. A low miR-802 expression was significantly correlated with the tumor stage, lymph node metastasis and brain metastasis in NSCLC patients. Restoring miR-802 expression inhibited NSCLC cell proliferation and colony formation, induced cell apoptosis, decreased cell migration and invasion in vitro, and hindered in vivo tumor growth. Mechanistically, fibroblast growth factor receptor 1 (FGFR1) was confirmed as the target gene of miR-802 in NSCLC cells. In addition, FGFR1 silencing mimicked the tumor-suppressing roles of miR-802 upregulation in NSCLC cells. Furthermore, rescue experiments revealed that FGFR1 reintroduction rescued the miR-802-induced inhibition of the malignant phenotypes in NSCLC cells. Notably, miR-802 was able to deactivate the phosphoinositide 3-kinase (PI3K)/AKT serine/threonine kinase (Akt)/mammalian target of rapamycin (mTOR) pathway in NSCLC cells in vitro and in vivo. Overall, these results demonstrated that miR-802 could downregulate FGFR1 expression, thereby deactivating the PI3K/Akt/mTOR pathway and inhibiting the malignant development of NSCLC. Thus, miR-802 may be a therapeutic candidate for patients with NSCLC.

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Section: Introductionmentioning

confidence: 99%

miR‑802 inhibits the aggressive behaviors of non‑small cell lung cancer cells by directly targeting FGFR1

Zhang

et al. 2019

Int J Oncol

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“…MicroRNAs (miRNAs) are small noncoding RNAs that play a negative role in regulating gene expression [6,12]. MicroRNA expression is often increased in human malignant tumors, resulting in increased tumor growth, invasion, and metastasis [12,13].…”

Section: Introductionmentioning

confidence: 99%

MiR-519d targets HER3 and can be used as a potential serum biomarker for non-small cell lung cancer

Wang

Zhang

Wang

et al. 2020

Aging

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Development of specific serum biomarkers is essential to improve diagnosis and prognosis of non-small cell lung cancer (NSCLC). Here, we show that serum and tissue levels of miR-519d are significantly decreased in NSCLC patients. The low expression of miR-519d is associated with lymph node metastases, clinical stage, and a poor prognosis in NSCLC patients. In addition, ROC analysis demonstrated that the serum miR-519d levels can distinguish NSCLC patients from healthy controls. MiR-519d inhibits proliferation, migration, and invasion by lung cancer cells, indicating that it may function as a tumor suppressor in lung cancer. Furthermore, our data demonstrate that HER3 is a target gene of miR-519d in lung cancer cells, and show that by targeting HER3, miR-519d inhibits the PI3K/Akt pathway. These findings demonstrate that the miR-519d levels are decreased in serum and tumor tissues of NSCLC patients, and indicate that miR-519d regulates NSCLC progression by targeting HER3. MiR-519d could potentially serve as a novel serum biomarker for NSCLC.

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“…Wang and his colleagues identified that 11 miRNAs, as well as their target genes and transcription factors, may be profitable in the prognostic prediction of NSCLC as biomarkers. In NSCLC blood samples, Wang et al [46] found that serum miR-98 expression was down-regulated in patients with NSCLC, and the decreased serum miR-98 was positively correlated with a worse TNM stage, lymph node metastasis, as well as unfavorable overall survival. Guo et al [47] showed that a decreased miR-204 level in plasma is associated with a poor prognosis in NSCLC patients.…”

Section: The Prognostic Value Of Mirnas In Nsclcmentioning

confidence: 99%

“…In NSCLC tissues, Li et al [49] report that miR-146 is highly expressed in cancer tissues, which can be used to predicts the prognosis of NSCLC. Wang et al [46] reveal that there is an obviously down-regulated miR-148b expression in NSCLC tissues, and the low miR-148b expression is closely related with poor survival of NSCLC patients. Zhang et al [50] demonstrate that a high expression level of miR-221 is associated with the short overall survival time for NSCLC patients.…”

Section: The Prognostic Value Of Mirnas In Nsclcmentioning

confidence: 99%

A review of microRNAs related to the occurrence, diagnosis, and prognosis of non-small cell lung cancer

Wang

Jiang

et al. 2018

Clin Surg Res Commun

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Non-small cell lung cancer (NSCLC) is the main most common type of lung cancer, accounting for about 80% of all cases. The five-year survival rate of patients with NSCLC is usually less than 20%. MicroRNAs (miRNAs), a type of small non-coding RNA, are closely related to the development and occurrence of tumors, including NSCLC. Here, we reviewed the miRNAs related to the occurrence, diagnosis and prognosis of NSCLC.

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Low serum miR-98 as an unfavorable prognostic biomarker in patients with non-small cell lung cancer

Abstract: Therefore, serum miR-98 might be useful as a promising biomarker for prognosis prediction of NSCLC.

Cited by 19 publications

References 19 publications

miR‑802 inhibits the aggressive behaviors of non‑small cell lung cancer cells by directly targeting FGFR1

miR‑802 inhibits the aggressive behaviors of non‑small cell lung cancer cells by directly targeting FGFR1

MiR-519d targets HER3 and can be used as a potential serum biomarker for non-small cell lung cancer

A review of microRNAs related to the occurrence, diagnosis, and prognosis of non-small cell lung cancer

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