Low serum magnesium is associated with poor functional outcome in acute ischemic stroke or transient ischemic attack patients

Xu, Qin; Hu, Lele; Chen, Lu; Li, Hao; Tian, Xue; Zuo, Yingting; Zhang, Yijun; Zhang, Xiaoli; Sun, Peng; Wang, Yongjun; Meng, Xia; Wang, Anxin

doi:10.1111/cns.14020

Cited by 5 publications

(2 citation statements)

References 69 publications

(122 reference statements)

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“…Subgroup analysis revealed that the association between glycemic gap and stroke recurrence was significant in DM and marginally significant in patients without DM, which might indicate that both uncontrolled DM and stress‐induced hyperglycemia in patients without DM could induce the development of stroke recurrence. Besides, the rates of mortality (11.0%) 2 and favorable functional outcome (81.6%) 29 were similar to previous reports, and a higher glycemic gap was related to an increased risk of mortality and a reduced likelihood of favorable functional outcome. Roberts et al suggested that stress hyperglycemia was associated with poor functional outcome in patients with ischemic stroke 30 .…”

Section: Discussionsupporting

confidence: 89%

Association of glycemic gap with stroke recurrence in patients with ischemic stroke

Yuan

Xie

Hou

et al. 2023

Journal of Diabetes

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BackgroundGlycemic gap, as a novel index of acute glycemic excursion, is associated with poor prognosis of different diseases. This study aimed to explore the association of the glycemic gap with long‐term stroke recurrence in patients with ischemic stroke.MethodsThis study included patients with ischemic stroke from the Nanjing Stroke Registry Program. The glycemic gap was calculated by subtracting the estimated average blood glucose from the blood glucose at admission. Multivariable Cox proportional hazards regression analysis was performed to explore the association between the glycemic gap and the risk of stroke recurrence. The Bayesian hierarchical logistic regression model was used to estimate the effects of the glycemic gap on stroke recurrence stratified by diabetes mellitus and atrial fibrillation.ResultsAmong 2734 enrolled patients, 381 (13.9%) patients experienced stroke recurrence during a median follow‐up of 3.02 years. In multivariate analysis, glycemic gap (high group vs. median group) was associated with significantly increased risk for stroke recurrence (adjusted hazard ratio, 1.488; 95% confidence interval, 1.140–1.942; p = .003) and had varying effects on stroke recurrence depending on atrial fibrillation. The restricted cubic spline curve showed a U‐shaped relationship between the glycemic gap and stroke recurrence (p = .046 for nonlinearity).ConclusionOur study found that the glycemic gap was significantly associated with stroke recurrence in patients with ischemic stroke. The glycemic gap was consistently associated with stroke recurrence across subgroups and had varying effects depending on atrial fibrillation.

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Section: Discussionsupporting

confidence: 89%

Association of glycemic gap with stroke recurrence in patients with ischemic stroke

Yuan

Xie

Hou

et al. 2023

Journal of Diabetes

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“…Despite magnesium's widespread presence in food sources, magnesium deficiency remains prevalent globally, even in developed nations [ 7 ]. The 2015-2020 dietary guidelines for Americans highlight that most Americans do not meet the recommended daily magnesium intake [ 8 ]. Recent studies spanning the past 15 years have linked hypomagnesemia to ischemic stroke, with reports indicating its presence in 24% of patients with acute ischemic stroke (AIS) [ 9 ] and in 20%-65% of critically ill ICU cases.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Hypomagnesemia and Its Relationship With Severity Among Patients of Acute Ischemic Stroke Presenting to a Tertiary Care Hospital

Khanum,

Arshad,

ullah

et al. 2024

Cureus

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The objective of this study was to assess the prevalence of hypomagnesemia and its association with the severity of acute ischemic stroke (AIS) in patients presenting at a tertiary care hospital. MethodologyA total of 100 patients with AIS were included in the study. Demographic data, including age, gender, and severity of stroke, were collected. Serum magnesium levels were measured at admission, and the severity of stroke was classified as mild, moderate, or severe based on clinical criteria. The presence of hypomagnesemia was defined as a serum magnesium level below 1.8 mg/dL determined within 72 hours of onset of stroke. Statistical analysis was performed to assess the association between hypomagnesemia, stroke severity, age, and gender. ResultsThe mean age of the patients with standard deviation was 65.45 ± 11.8 years, with the majority (38, 38%) aged 60-74 years. There were 53 (53%) male and 47 (47%) female patients. Hypomagnesemia was found in 35 (35%) patients, with an average magnesium level of 1.93 mg/dL and a standard deviation of 0.37 at admission. There was no statistically significant difference in the distribution of stroke severity (P = 0.779; P = 0.406) or hypomagnesemia (P = 0.287; P = 0.591) based on gender or age group, respectively. Stratification based on stroke severity showed that 16 (39%) patients with mild stroke, 10 (31.3%) with moderate stroke, and 9 (33.3%) with severe stroke had hypomagnesemia. The correlation between stroke severity and hypomagnesemia was weak (r = 0.099). Further, among hypomagnesemia patients, the majority were females aged 60-74 years. ConclusionsThis study found a weak positive relationship between the severity of AIS and the presence of hypomagnesemia. However, no statistically significant association was observed between gender or age group and stroke severity or hypomagnesemia. These findings suggest that further research is needed to understand the role of hypomagnesemia in AIS and its potential implications for patient management.

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Higher Magnesium Depletion Score Increases the Risk of All-cause and Cardiovascular Mortality in Hypertension Participants

Song,

Zhang,

Lin

et al. 2024

Biol Trace Elem Res

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Low serum magnesium is associated with poor functional outcome in acute ischemic stroke or transient ischemic attack patients

Cited by 5 publications

References 69 publications

Association of glycemic gap with stroke recurrence in patients with ischemic stroke

Association of glycemic gap with stroke recurrence in patients with ischemic stroke

Frequency of Hypomagnesemia and Its Relationship With Severity Among Patients of Acute Ischemic Stroke Presenting to a Tertiary Care Hospital

Higher Magnesium Depletion Score Increases the Risk of All-cause and Cardiovascular Mortality in Hypertension Participants

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