Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients

Parisse, Simona; Ferri, Flaminia; Persichetti, Marzia; Mischitelli, Monica; Abbatecola, Aurelio; Martino, Michele Di; Lai, Quirino; Carnevale, Sara; Lucatelli, Pierleone; Bezzi, Mario; Rossi, Massimo; Santis, Adriano De; Spagnoli, Alessandra; Corradini, Stefano Ginanni

doi:10.1038/s41598-021-94509-6

Cited by 5 publications

(7 citation statements)

References 43 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, mouse experiments have validated that the growth of primary tumors sequesters Mg from the extracellular environment, leading to hypomagnesemia [60]. Additionally, both our work and other studies have described the higher preference of Mg absorption in tumors than normal tissues, which may raise the possibility of reducing serum Mg levels [60,70]. However, this speculation requires further evidence.…”

Section: Discussionsupporting

confidence: 59%

Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer

Zhang,

Hu,

Liu

et al. 2024

Preprint

View full text Add to dashboard Cite

Magnesium (Mg) deficiency is associated with increased risk and malignancy of colorectal cancer (CRC), yet the underlying mechanisms remain elusive. Here we used genomic, proteomic, and phosphoproteomic data to elucidate the impact of Mg deficiency on CRC. Genomic analysis identified 160 genes with higher mutation frequencies in Low-Mg tumors, including key driver genes such as KMT2C and ERBB3. Unexpectedly, initiation driver genes of CRC, such as TP53 and APC, displayed higher mutation frequencies in High-Mg tumors. Additionally, proteomics and phosphoproteomics indicated that low tumorous Mg content may activate epithelial-mesenchymal transition (EMT) by modulating inflammation or remodeling the phosphoproteome of cancer cells. Notably, we observed a negative correlation between the phosphorylation of DBN1 at S142 (DBN1S142p) and Mg content. A mutation in S142 to D (DBN1S142D) mimicking DBN1S142p upregulated MMP2 and enhanced cell migration, while treatment with MgCl2 reduced DBN1S142p, thereby reversing this phenotype. Mechanistically, Mg2+ attenuated the DBN1-ACTN4 interaction by decreasing DBN1S142p, which, in turn, enhanced the binding of ACTN4 to F-actin and promoted F-actin polymerization, ultimately reducing MMP2 expression. These findings shed new light on the crucial role of Mg deficiency in CRC progression and suggest that Mg supplementation may offer a promising preventive and therapeutic strategy for CRC.

show abstract

Section: Discussionsupporting

confidence: 59%

Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer

Zhang,

Hu,

Liu

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Epidemiological studies on the association between serum magnesium and HCC risk are limited. A case‐control study of 130 HCC cases and 161 non‐HCC cases within a cohort of cirrhotic patients because of all causes in Italy reported that cirrhotic patients with HCC had significantly lower levels of serum magnesium than patients with cirrhosis without HCC, suggesting that magnesium might offer certain protection against the development of HCC in patients with cirrhosis 28 . In general, our results derived from a study with prospective design and large sample size were consistent with those in previous studies as described previously.…”

Section: Discussionmentioning

confidence: 99%

“…However, there have been no epidemiological studies on serum levels of magnesium, which is more objective and biologically relevant, in relation to HCC risk. Previous reports found that serum magnesium level was lower in patients with cirrhosis and HCC than those without HCC in an Italian population 28 . However, this study was a cross‐sectional study design with a small sample size (total of 291 patients) and diverse underlying risk factors for HCC including HBV, HCV, and alcohol abuse.…”

Section: Introductionmentioning

confidence: 92%

“…Previous reports found that serum magnesium level was lower in patients with cirrhosis and HCC than those without HCC in an Italian population. 28 However, this study was a cross-sectional study design with a small sample size (total of 291 patients) and diverse underlying risk factors for HCC including HBV, HCV, and alcohol abuse. Therefore, the association between serum magnesium and HCC risk warrants further investigation in a large prospectively designed cohort study.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

High serum magnesium is associated with lower risk of hepatocellular carcinoma among patients with nonalcoholic fatty liver disease

Paragomi

Wang

et al. 2023

Cancer

View full text Add to dashboard Cite

Background: Nonalcoholic fatty liver disease (NAFLD) is a major contributor to the rising incidence of hepatocellular carcinoma (HCC). Magnesium is a major cation in cellular activities. Epidemiological data on magnesium level and its relation to HCC are sparse. This study aimed to examine the associations between serum levels of magnesium and the risk of HCC among patients with NAFLD.Methods: A total of 26,053 patients with NAFLD were identified in the University of Pittsburgh Medical Center Electronic Health Records from 2004 through 2018.After an average of 5.15 years of follow-up, 395 patients developed HCC after the first measurement of serum magnesium. Cox proportional hazards regression model was used to calculate hazard ratios (HRs) and 95% CIs of HCC incidence associated with quartile levels of serum magnesium after adjustment for age, sex, race, body mass index, diuretics use, history of type 2 diabetes, history of hypertension, history of hyperlipidemia, and tobacco smoking.Results: Patients with NAFLD who developed HCC had a significantly lower mean (� standard deviation) serum magnesium (0.769 � 0.131 mmol/L) than those who remained free of HCC (0.789 � 0.125 mmol/L; p = .003). Compared with the lowest quartile, the HRs (95% CIs) of HCC second, third, and fourth quartiles of serum magnesium were 0.87 (0.67-1.12), 0.77 (0.57-1.04), and 0.73 (0.56-0.96), respectively, after adjustment for multiple potential confounders (P trend = .02). Conclusion:This finding suggests higher levels of serum magnesium were significantly associated with decreased risk of HCC among patients with NAFLD.

show abstract

“…Serum Mg c oncentration s often decrease in patients w ith neoplasia regardless of treatments (Sartori et al, 1992). One of the possible reasons for this is that tumors act as Mg traps, thereby disrupting the Mg balance of the body, resulting in a lower serum Mg concentration (Parisse et al, 2021). Low serum Mg status has also been associated with increased inflammation in combination with increased oxidative stress in humans (Nielsen, 2010).…”

Section: The Changes In Serum Trace Element Levels Between the Groupsmentioning

confidence: 99%

Determination of Serum Trace Elements and Oxidative Stress in Bitches with Transmissible Venereal Tumor

Akkuş¹,

Ekici²

2023

IJAR

View full text Add to dashboard Cite

Background: This study was conducted to compare the changes in oxidative stress levels with some trace elements in blood serum in healthy bitches and bitches with transmissible venereal tumor (TVT). Methods: A total of 40 bitches were used in the study. According to the genital organ examinations, healthy bitches constituted the control group (n=20) and those with venereal tumors constituted the TVT group (n=20). Total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were determined spectrophotometrically. In addition, some serum trace element levels such as magnesium (Mg), manganese (Mn), iron (Fe), copper (Cu), zinc (Zn) and selenium (Se) were measured using an ICP-MS analysis device. Result: The serum Se, Mg and Zn levels were lower in the TVT group compared to the control group (p less than 0.01) and serum Fe and Cu levels were higher in the TVT group than in the control group (p less than 0.01). Serum TOS and OSI levels were higher (p less than 0.001) and serum TAS levels were lower (p less than 0.001) in the TVT group compared to the control group. The study results showed that oxidative stress is high in bitches with TVT, and in parallel with this, changes occur in the amount of certain trace elements that are associated with oxidative stress.

show abstract

Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients

Cited by 5 publications

References 43 publications

Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer

Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer

High serum magnesium is associated with lower risk of hepatocellular carcinoma among patients with nonalcoholic fatty liver disease

Determination of Serum Trace Elements and Oxidative Stress in Bitches with Transmissible Venereal Tumor

Contact Info

Product

Resources

About