Low serum level of 25‐OH vitamin D relates to Th17 and treg changes in colorectal cancer patients

Chen, Bai; Jin, Liugen

doi:10.1002/iid3.723

Cited by 6 publications

(8 citation statements)

References 31 publications

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“…It inhibits T-cell proliferation and promotes the induction of T-regulatory cells [ 43 , 44 ]. Consequently, inflammatory cytokines, such as interleukin 17 (IL17) and IL21, are decreased, while anti-inflammatory cytokines, such as IL 10, are increased [ 45 , 46 ]. Monocyte production of the inflammatory cytokines, including IL 1, IL 6, IL 8, IL 12, and tumor necrosis factor-α (TNFα), is inhibited in the presence of vitamin D [ 47 ], and it also inhibits the differentiation and maturation of the dendritic cells [ 48 ].…”

Section: Vitamin D and Immune Functionmentioning

confidence: 99%

Vitamin D and Omega-3 (Fatty Acid) Supplementation in Pregnancy for the Primary Prevention of Food Allergy in Children-Literature Review

et al. 2023

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During the last decades the prevalence of food allergy (FA), an adverse immune response to a specific food antigen, has risen, with negative effects on the quality of life (QoL) of many children and their families. The pathogenesis of FA is complex, involving both genetic and environmental factors. SPINK5, STAT6, HLA and FOXP3 are some of the genes that are reported to be implicated in FA development. Regarding environmental factors, particular interest has been focused on modification of the dietary habits of pregnant women for the primary prevention of FA. Specifically, Vitamin D and omega-3 (Ω-3) fatty acid supplementation during pregnancy may influence the development of FA in the offspring. Vitamin D is a hormone with various actions, including mediation of the immune system, reducing the production of inflammatory cytokines and promoting tolerance. Vitamin D deficiency in pregnancy suppresses T-regulatory cells in the fetus, and Vitamin D supplementation might protect against FA development. Dietary Ω-3 fatty acids are found mainly in fish and vegetable oils. They are beneficial for human health, playing a role in the immune system as anti-inflammatory agents, and providing cell membrane stabilization with inhibition of antigen presentation. It is documented that maternal supplementation with Ω-3 during pregnancy may protect from allergic sensitization in the children. The aim of this literature review was to explore the potential preventive role of maternal supplementation during pregnancy with Vitamin D and Ω-3 in the development of FA in the offspring. With the prevalence of FA rising, all the possible protective mechanisms and measures for FA prevention need to be explored, starting with those that can be modified.

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Section: Vitamin D and Immune Functionmentioning

confidence: 99%

Vitamin D and Omega-3 (Fatty Acid) Supplementation in Pregnancy for the Primary Prevention of Food Allergy in Children-Literature Review

et al. 2023

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“…VDR signaling pathway has a crucial role in several physiological activities, such as bone development, anti-inflammatory response, and anti-tumor activities ( Shang and Sun, 2017 ). Notably, a decrease in both the serum vitamin D levels and the expression of VDR in the colon has been observed in patients with colitis or colorectal cancer ( Chen and Jin, 2022 ; Ma et al, 2023 ). In a study using a mouse model of colitis-associated cancer, treatment with asperuloside was found to significantly enhance the expression of VDR in the colon, leading to marked reductions in colitis symptoms and a decrease in both the quantity and size of tumors ( Lu et al, 2022 ).…”

Section: Natural Bioactive Compounds Targeting Vdr Activitymentioning

confidence: 99%

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Yao,

Oduro,

Akintibu

et al. 2024

Front. Pharmacol.

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The Vitamin D receptor (VDR) is a crucial nuclear receptor that plays a vital role in various physiological functions. To a larger extent, the genomic effects of VDR maintain general wellbeing, and its modulation holds implications for multiple diseases. Current evidence regarding using vitamin D or its synthetic analogs to treat non-communicable diseases is insufficient, though observational studies suggest potential benefits. Traditional Chinese medicines (TCMs) and bioactive compounds derived from natural sources have garnered increasing attention. Interestingly, TCM formulae and TCM-derived bioactive compounds have shown promise in modulating VDR activities. This review explores the intriguing potential of TCM and bioactive compounds in modulating VDR activity. We first emphasize the latest information on the genetic expression, function, and structure of VDR, providing a comprehensive understanding of this crucial receptor. Following this, we review several TCM formulae and herbs known to influence VDR alongside the mechanisms underpinning their action. Similarly, we also discuss TCM-based bioactive compounds that target VDR, offering insights into their roles and modes of action.

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“…7 VitD supplementation decreases Th1/Th17 and memory B cells, which contribute to SLE-related inflammation, and increases Treg cells, which inhibit SLE-related proinflammatory response. 8 Previous studies by our group have revealed that VitD can improve inflammation, immunity, and bone metabolism in SLE mice and can bind to its receptors to treat SLE by inhibiting Th cells, related factors, the microenvironment, and the production of autoimmune antibodies. 9,10 The Wnt signaling pathway has been extensively studied.…”

Section: Introductionmentioning

confidence: 99%

“…SLE is characterized by the hyperreactivity of B and T cells, loss of immune tolerance, overproduction of autoantibodies, and inflammation of multiple organ systems 7 . VitD supplementation decreases Th1/Th17 and memory B cells, which contribute to SLE‐related inflammation, and increases Treg cells, which inhibit SLE‐related pro‐inflammatory response 8 . Previous studies by our group have revealed that VitD can improve inflammation, immunity, and bone metabolism in SLE mice and can bind to its receptors to treat SLE by inhibiting Th cells, related factors, the microenvironment, and the production of autoimmune antibodies 9,10…”

Section: Introductionmentioning

confidence: 99%

Vitamin D improves autoimmune diseases by inhibiting Wnt signaling pathway

Zou,

Song,

Yin

et al. 2024

Immunity Inflam & Disease

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ObjectiveIn this study, we investigated the development of the Wnt signaling pathway in vitamin D (VitD) to improve systemic lupus erythematosus in mice to breakthrough clinical treatment approaches.MethodsBody weight changes were recorded during rearing. Antinuclear antibodies (ANA), anti‐dsDNA, and anti‐snRNP were detected in the mouse serum using an enzyme‐linked immunosorbent assay. Apoptosis of Th1 and Th2 immune cells in mice was detected using flow cytometry. Reverse transcription polymerase chain reaction was used to detect the expression of T‐bet, GATA3, and Wnt3a mRNA in the spleens of each group. Western blot analysis was performed to detect the expression of Wnt1, p‐β‐catenin, β‐catenin, glycogen synthase kinsase3β (GSK‐3β), Wnt3a, c‐myc, and cyclin D1 protein in mice spleens. β‐catenin in mice spleen was visualized using immunohistochemistry.ResultsVitD did not substantial reduce the body weight of MRL/LPR mice, whereas the inhibitor did. VitD notably decreased the concentrations of ANA, anti‐double‐stranded DNA, and anti‐snRNP in the serum of MRL/LPR mice and alleviated apoptosis of Th1 and Th2 cells. VitD markedly increased the expression of T‐bet and GATA mRNA in the spleen of MRL/LPR mice and consequently increased the levels of Wnt3a and β‐catenin. Western blot analysis revealed that the levels of GSK‐3β, p‐β‐catenin, Wnt1, Wnt3a, c‐myc, and cyclin D1 could be reduced by VitD, compared with MRL/LPR. Immunohistochemistry demonstrated that the expression of β‐catenin was the most pronounced in the spleen of MRL/LPR mice, and the expression level of β‐catenin decreased substantially after VitD intervention.ConclusionsVitD can further inhibit the nuclear translocation of β‐catenin by downregulating the expression of Wnt ligands (Wnt1 and Wnt3a), which reduces the expression of the downstream target gene cyclin D1. Systemic lupus erythematosus in mice was improved by inhibiting the activation of Wnt/β‐catenin signal pathway.

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Low serum level of 25‐OH vitamin D relates to Th17 and treg changes in colorectal cancer patients

Cited by 6 publications

References 31 publications

Vitamin D and Omega-3 (Fatty Acid) Supplementation in Pregnancy for the Primary Prevention of Food Allergy in Children-Literature Review

Vitamin D and Omega-3 (Fatty Acid) Supplementation in Pregnancy for the Primary Prevention of Food Allergy in Children-Literature Review

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Vitamin D improves autoimmune diseases by inhibiting Wnt signaling pathway

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