Low serum high‐density lipoprotein cholesterol in childhood is associated with adolescent asthma

Yiallouros, Panayiotis K.; Savva, S. C.; Kolokotroni, Ourania; Behbod, Behrooz; Zeniou, Maria; Economou, Mary; Chadjigeorgiou, C.; Kourides, Yiannis; Tornaritis, Michael; Lamnisos, Demetris; Middleton, Nicos; Milton, Donald K.

doi:10.1111/j.1365-2222.2011.03940.x

Cited by 36 publications

(33 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although prior studies have also assessed the relationship between serum HDL-C and asthma, the results have been heterogeneous with serum HDL-C levels either being increased, decreased, or unchanged in subjects with asthma (20,(43)(44)(45)(46)(47)(48)(49)(50). Similar to our findings, prior studies have also not found a change in serum LDL-C in subjects with asthma, whereas TC was either decreased or unchanged and TG levels were either increased or unchanged.…”

Section: Discussionsupporting

confidence: 79%

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Barochia¹,

Kaler²,

Cuento³

et al. 2015

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Rationale: Although lipids, apolipoproteins, and lipoprotein particles are important modulators of inflammation, varying relationships exist between these parameters and asthma.Objectives: To determine whether serum lipids and apolipoproteins correlate with the severity of airflow obstruction in subjects with atopy and asthma.Methods: Serum samples were obtained from 154 atopic and nonatopic subjects without asthma, and 159 subjects with atopy and asthma. Serum lipid and lipoprotein levels were quantified using standard diagnostic assays and nuclear magnetic resonance (NMR) spectroscopy. Airflow obstruction was assessed by FEV 1 % predicted.Measurements and Main Results: Serum lipid levels correlated with FEV 1 only in the subjects with atopy and asthma. Serum levels of high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) were positively correlated with FEV 1 in subjects with atopy and asthma, whereas a negative correlation existed between FEV 1 and serum levels of triglycerides, low-density lipoprotein (LDL) cholesterol, apolipoprotein B (apoB), and the apoB/apoA-I ratio. NMR spectroscopy identified a positive correlation between FEV 1 and HDL NMR particle size, as well as the concentrations of large HDL NMR particles and total IDL NMR (intermediate-density lipoprotein) particles in subjects with atopy and asthma. In contrast, LDL NMR particle size and concentrations of LDL NMR and VLDL NMR (very-low-density lipoprotein) particles were negatively correlated with FEV 1 in subjects with atopy and asthma.Conclusions: In subjects with atopy and asthma, serum levels of apoA-I and large HDL NMR particles are positively correlated with FEV 1 , whereas serum triglycerides, LDL cholesterol, and apoB are associated with more severe airflow obstruction. These results may facilitate future studies to assess whether apoA-I and large HDL NMR particles can reduce airflow obstruction and disease severity in asthma.

show abstract

Section: Discussionsupporting

confidence: 79%

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Barochia¹,

Kaler²,

Cuento³

et al. 2015

Am J Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

“…We calculated BMI (kg/m 2 ) and expressed it as age- and gender-specific z-scores based on the US Centers for Disease Control 2000 growth charts [15]. The methodology for the baseline assessment of serum lipids was described in our previous paper [11]. Lipids at follow-up were determined with the ILab 600 analyzer using ILab chemistry systems (Instrumentation Laboratory SpA, Monza, Italy).…”

Section: Methodsmentioning

confidence: 99%

“…The first survey in 2001-2003 involved all children (n = 19,849) attending the 6th form across all primary schools in Cyprus and focused on nutrition and physical fitness, and included measurements of serum total cholesterol, low-density-lipoprotein cholesterol (LDL-C), HDL-C, triglycerides and body mass index (BMI). The second survey in 2007 evaluated 3,982 subjects who were selected randomly from the subjects who took part in the first survey (20.1%) and focused on respiratory health (International Study of Asthma and Allergies in Childhood - ISAAC) and risk factors for asthma [11]. …”

Section: Methodsmentioning

confidence: 99%

“…No link of dyslipidemia to the allergic or nonallergic phenotype of asthma has been reported in human studies. In our 2012 study, after stratifying by family history of atopy, we were only able to report that the increased risk for asthma seemed to be particularly high in those children with a positive family history of atopy and low serum HDL [11]. …”

Section: Introductionmentioning

confidence: 99%

“…Most studies were limited by their cross-sectional design and the wide age range of the participants. In a cohort of 3,982 children in Cyprus, we recently reported low levels of high-density-lipoprotein cholesterol (HDL-C) at age 11-12 years to be associated with active asthma (AA) in adolescence (age 16-18 years), suggesting a potential role of this lipoprotein in the pathogenesis of pediatric asthma or, at least, coexistence of these two conditions in early life [11]. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Asthma: The Role of Low High-Density-Lipoprotein Cholesterol in Childhood and Adolescence

Yiallouros

Savva

Kolokotroni

et al. 2014

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Several studies have examined the relationship of asthma with serum dyslipidemia and reported positive, negative or no association. Most studies were limited by their cross-sectional design and the wide age range of the participants. In a cohort of children in Cyprus, we explored the association of asthma with serum high-density-lipoprotein cholesterol (HDL-C) at age 16-18 years (follow-up) independently of and in relation to HDL-C at age 11-12 years (baseline). Methods: In a case-control design, we recruited active asthmatics (AA; n = 68), current wheezers only (CWO; n = 123) and non-asthmatic controls (n = 660). Logistic regression models were used to evaluate associations of asthma with follow-up serum HDL-C and the role of baseline HDL-C. Results: At follow-up, mean HDL-C levels in AA and CWO patients were significantly lower than in the controls (47.9 and 49.7 vs. 53.4 mg/dl; p = 0.001 and p = 0.011). We observed significant associations of AA patients with low HDL-C (<15th percentile; OR 2.32, 95% CI 1.16-4.47) that remained significant after further adjustment for baseline HDL-C (OR 2.14, 95% CI 1.06-4.14). Stratification by baseline HDL-C indicated that the association was significant only in those with high baseline HDL-C (OR 2.40, 95% CI 1.03-5.20). Stratification by IgE sensitization showed that the association was pronounced only in subjects who were sensitized (OR 3.41, 95% CI 1.12-9.88). Conclusions: Adolescent asthma is associated with low serum HDL-C independent of previous HDL-C levels in childhood. The association appears pronounced in those with a drop in HDL-C levels between childhood and adolescence and in those who have IgE sensitization. i 2014 S. Karger AG, Basel

show abstract

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice

Smet

Hoecke

Beuckelaer

et al. 2016

Immunity, Inflammation and Disease

View full text Add to dashboard Cite

IntroductionLiver X receptors (LXRs) are nuclear receptors that function as cholesterol sensors and regulate cholesterol homeostasis. High cholesterol has been recognized as a risk factor in asthma; however, the mechanism of this linkage is not known.MethodsTo explore the importance of cholesterol homeostasis for asthma, we investigated the contribution of LXR activity in an ovalbumin‐ and a house dust mite‐driven eosinophilic asthma mouse model.ResultsIn both models, airway inflammation, airway hyper‐reactivity, and goblet cell hyperplasia were reduced in mice deficient for both LXRα and LXRβ isoforms (LXRα−/−β−/−) as compared to wild‐type mice. Inversely, treatment with the LXR agonist GW3965 showed increased eosinophilic airway inflammation. LXR activity contributed to airway inflammation through promotion of type 2 cytokine production as LXRα−/−β−/− mice showed strongly reduced protein levels of IL‐5 and IL‐13 in the lungs as well as reduced expression of these cytokines by CD4+ lung cells and lung‐draining lymph node cells. In line herewith, LXR activation resulted in increased type 2 cytokine production by the lung‐draining lymph node cells.ConclusionsIn conclusion, our study demonstrates that the cholesterol regulator LXR acts as a positive regulator of eosinophilic asthma in mice, contributing to airway inflammation through regulation of type 2 cytokine production.

show abstract

Low serum high‐density lipoprotein cholesterol in childhood is associated with adolescent asthma

Abstract: Low-serum high-density lipoprotein cholesterol in childhood is associated with an increased risk for asthma in adolescence, suggesting a potential role of this lipoprotein in the pathogenesis of paediatric asthma.

Cited by 36 publications

References 51 publications

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Asthma: The Role of Low High-Density-Lipoprotein Cholesterol in Childhood and Adolescence

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice

Contact Info

Product

Resources

About

Low serum high‐density lipoprotein cholesterol in childhood is associated with adolescent asthma

Abstract: Low-serum high-density lipoprotein cholesterol in childhood is associated with an increased risk for asthma in adolescence, suggesting a potential role of this lipoprotein in the pathogenesis of paediatric asthma.

Cited by 36 publications

References 51 publications

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV1 in Atopic Asthma

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV1 in Atopic Asthma

Asthma: The Role of Low High-Density-Lipoprotein Cholesterol in Childhood and Adolescence

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice

Contact Info

Product

Resources

About

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma

Serum Apolipoprotein A-I and Large High-Density Lipoprotein Particles Are Positively Correlated with FEV₁ in Atopic Asthma