Low serum free thyroxine level is correlated with lipid profile in depressive patients with suicide attempt

Peng, Rui; Dai, Wen; Li, Yan

doi:10.1016/j.psychres.2018.05.059

Cited by 61 publications

(44 citation statements)

References 25 publications

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“…Risk factors for SI specific to MDD include vocational/employment and marital status, 9,10 gender, [11][12][13][14] age at onset, 15 depression severity, 9,11,15,16 comorbidity with other mental disorder 17 and lower hypothalamic-pituitary-thyroid (HPT) axis activity. 18 Several studies have explored the prevalence of SI in patients with MDD, the prevalence ranged from 18.0% to 58.0%. 13,19 A recent meta-analysis indicates that the pooled lifetime prevalence of SI was 53.1% and one-month prevalence of SI was 27.5% among MDD in China.…”

Section: Introductionmentioning

confidence: 99%

<p>Identifying Suicidal Ideation Among Chinese Patients with Major Depressive Disorder: Evidence from a Real-World Hospital-Based Study in China</p>

Ge¹,

Jiang²,

Wang³

et al. 2020

NDT

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These authors contributed equally to this work Background: A growing body of research suggests that major depressive disorder (MDD) is one of the most common psychiatric conditions associated with suicide ideation (SI). However, how a combination of easily accessible variables built a utility clinically model to estimate the probability of an individual patient with SI via machine learning is limited. Methods: We used the electronic medical record database from a hospital located in western China. A total of 1916 Chinese patients with MDD were included. Easily accessible data (demographic, clinical, and biological variables) were collected at admission (on the first day of admission) and were used to distinguish SI with MDD from non-SI using a machine learning algorithm (neural network). Results: The neural network algorithm distinguished 1356 out of 1916 patients translating into 70.08% accuracy (70.68% sensitivity and 67.09% specificity) and an area under the curve (AUC) of 0.76. The most relevant predictor variables in identifying SI from non-SI included free thyroxine (FT4), the total scores of Hamilton Depression Scale (HAMD), vocational status, and free triiodothyronine (FT3). Conclusion: Risk for SI among patients with MDD can be identified at an individual subject level by integrating demographic, clinical, and biological variables as possible as early during hospitalization (at admission).

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Section: Introductionmentioning

confidence: 99%

<p>Identifying Suicidal Ideation Among Chinese Patients with Major Depressive Disorder: Evidence from a Real-World Hospital-Based Study in China</p>

Ge¹,

Jiang²,

Wang³

et al. 2020

NDT

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“…HDL possesses antioxidative properties, and it could inhibit intracellular generation of reactive oxygen species, protect LDL from oxidative damage, and remove oxidized lipids from oxidized LDL . Previous studies have demonstrated that the serum level of LDL increased in depressive subjects compared with healthy controls . Kuwano et al.…”

Section: Discussionmentioning

confidence: 99%

“…,26 Kuwano et al (2018) have hypothesized that the downregulation of antioxidative activity due to lower serum HDL-C levels might lead to increased severity of depression, and that HDL-C might work as an antidepressant through antioxidative activity 27. Simultaneously, it is also possible that the decreased serum cholesterol and increased HDL-C levels in reserpine-mice with OEO-supplemented are due to the antioxidative effects of OEO.…”

mentioning

confidence: 99%

Dietary essential oil from navel orange alleviates depression in reserpine‐treated mice by monoamine neurotransmitters

Zhang

Yang

Ren

et al. 2019

Flavour & Fragrance J

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This study was intended to examine the effects of navel orange (Citrus sinensis (L.) Osbeck) essential oil (OEO) on depression in the reserpine‐treated mice. And the chemical composition of OEO was analysed by gas chromatography (GC) analysis. The results indicated that the major compounds of OEO were terpenes. And OEO treatment produced an antidepressant‐like effect in mice, as indicated by the increased locomotor activity in the open field test (OFT) and attenuated dyslipidemia, but it had no effect on duration of immobility in the forced swim test (FST). Dietary OEO counteracted the reserpine‐induced hypothermia and palpebral ptosis. Moreover, OEO treatment increased the levels of serotonin (5‐HT) and dopamine (DA) in the mice brain. These antidepressant‐like effects of OEO are essentially similar to the effects of the antidepressant fluoxetine. And the action of OEO may be mediated by the central serotonergic and dopaminergic systems.

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“…Peng et al. found that low serum levels of free thyroxine affects the lipid profile in patients with major depressive disorder and who have attempted suicide . Pan et al.…”

Section: Potential Mechanisms Underlying Increased Tb Susceptibility mentioning

confidence: 99%

“…122 Peng et al found that low serum levels of free thyroxine affects the lipid profile in patients with major depressive disorder and who have attempted suicide. 123 Pan et al showed that the antidepressant drug fluoxetine induces lipid metabolism abnormalities by acting on the liver in both mouse models of depression and affected patients. 124 While additional studies to clarify the alterations to lipid metabolism in patients with depression are required, it is possible that manipulating lipid metabolism may be a potential therapeutic target for anti-TB treatment.…”

Section: Depression Influences Tb Susceptibility Via Alterations To Lmentioning

confidence: 99%

The interplay between depression and tuberculosis

Zhang

Wang

et al. 2019

Journal of Leukocyte Biology

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Depression is a major mental health condition and is expected be the most debilitating and widespread health disorder by 2030. Tuberculosis (TB) is also a leading cause of morbidity and mortality worldwide and interestingly, is a common comorbidity of depression. As such, much attention has been paid to the association between these 2 pathologies. Based on clinical reports, the association between TB and depression seems to be bidirectional, with a substantial overlap in symptoms between the 2 conditions. TB infection or reactivation may precipitate depression, likely as a consequence of the host's inflammatory response and/or dysregulation of the hypothalamic–pituitary–adrenal axis. Nevertheless, few studies have considered whether patients with depression are at a higher risk for TB. In this review, we discuss the hypotheses on the association between depression and TB, highlighting the immuno‐inflammatory response and lipid metabolism as potential mechanisms. Improving our understanding of the interplay between these 2 disorders should help guide TB clinical care and prevention both in patients with comorbid depression and in the general population.

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Low serum free thyroxine level is correlated with lipid profile in depressive patients with suicide attempt

Cited by 61 publications

References 25 publications

<p>Identifying Suicidal Ideation Among Chinese Patients with Major Depressive Disorder: Evidence from a Real-World Hospital-Based Study in China</p>

<p>Identifying Suicidal Ideation Among Chinese Patients with Major Depressive Disorder: Evidence from a Real-World Hospital-Based Study in China</p>

Dietary essential oil from navel orange alleviates depression in reserpine‐treated mice by monoamine neurotransmitters

The interplay between depression and tuberculosis

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