Low serum ferritin and G6PD deficiency as potential predictors of anaemia in pregnant women visiting Prime Care Hospital Enugu Nigeria

Engwa, Godwill Azeh; Unaegbu, Marcellus; Unachukwu, M. N; Njoku, Mary-Gloria C.; Agbafor, K. N.; Mbacham, Wilfred Fon; Okoh, Anthony I.

doi:10.1186/s13104-017-3051-5

Cited by 8 publications

(5 citation statements)

References 30 publications

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“…Neonatal jaundice, requiring treatment with phototherapy, was the commonest neonatal condition (43.6%) and more common in Nigeria than in Kenya. This may reflect differences in newborn care practices and/or regional differences in the frequency of disorders causing neonatal haemolysis such as glucose-6-phosphate dehydrogenase deficiency [47][48][49][50]. Although jaundice is often mild, it can progress to kernicterus spectrum disorder, death and long-term severe neurological sequelae in survivors [51][52][53].…”

Section: Plos Onementioning

confidence: 99%

Burden of disease and risk factors for mortality amongst hospitalized newborns in Nigeria and Kenya

et al. 2021

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Objective To describe the patient population, priority diseases and outcomes in newborns admitted <48 hours old to neonatal units in both Kenya and Nigeria. Study design In a network of seven secondary and tertiary level neonatal units in Nigeria and Kenya, we captured anonymised data on all admissions <48 hours of age over a 6-month period. Results 2280 newborns were admitted. Mean birthweight was 2.3 kg (SD 0.9); 57.0% (1214/2128) infants were low birthweight (LBW; <2.5kg) and 22.6% (480/2128) were very LBW (VLBW; <1.5 kg). Median gestation was 36 weeks (interquartile range 32, 39) and 21.6% (483/2236) infants were very preterm (gestation <32 weeks). The most common morbidities were jaundice (987/2262, 43.6%), suspected sepsis (955/2280, 41.9%), respiratory conditions (817/2280, 35.8%) and birth asphyxia (547/2280, 24.0%). 18.7% (423/2262) newborns died; mortality was very high amongst VLBW (222/472, 47%) and very preterm infants (197/483, 40.8%). Factors independently associated with mortality were gestation <28 weeks (adjusted odds ratio 11.58; 95% confidence interval 4.73–28.39), VLBW (6.92; 4.06–11.79), congenital anomaly (4.93; 2.42–10.05), abdominal condition (2.86; 1.40–5.83), birth asphyxia (2.44; 1.52–3.92), respiratory condition (1.46; 1.08–2.28) and maternal antibiotics within 24 hours before or after birth (1.91; 1.28–2.85). Mortality was reduced if mothers received a partial (0.51; 0.28–0.93) or full treatment course (0.44; 0.21–0.92) of dexamethasone before preterm delivery. Conclusion Greater efforts are needed to address the very high burden of illnesses and mortality in hospitalized newborns in sub-Saharan Africa. Interventions need to address priority issues during pregnancy and delivery as well as in the newborn.

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Section: Plos Onementioning

confidence: 99%

Burden of disease and risk factors for mortality amongst hospitalized newborns in Nigeria and Kenya

et al. 2021

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“…[ 33 ] Long-term impact of malaria and G6PD deficiency on hematological profile includes anemia especially in pregnant women in tropical countries is reported by Engwa et al . [ 34 ] We studied hematological parameters also in both our groups. Though we did not find significant difference, hemoglobin analysis by HPLC showed 12 participants who had increased hemoglobin A2 levels, of which 10 were in “Malaria Occurrence Never” group, while rest 2 were in “Malaria Occurrence ever” group.…”

Section: Discussionmentioning

confidence: 99%

Assessment of protective relationship of G6PD and other lifestyle factors with Malaria: A case-control study of medical professionals from a teaching medical institute, Gujarat

Pandit¹,

Kalaria

Lakhani

et al. 2020

J Family Med Prim Care

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Background: There remains equivocal evidence in terms of glucose-6-phosphate dehydrogenase (G6PD) and malaria occurrence. A case-control study was performed to assess protective relationship of G6PD and other lifestyle factors with malaria. Methods: One-hundred twenty six medical professionals were randomly selected from a tertiary care clinical institute. Along with demographic and lifestyle details, subjects were interviewed about their history of occurrence of malaria at all in previous 10 years. Their hematological, biochemical, and metabolic profile was assessed clinically as well as by investigations. The analysis was carried out with two groups: (1) those who were subjected with malaria at least once in past 10 years ( Malaria Ever Group ); (2) those who never encountered malaria (Malaria Never Group). Results: Out of 126, 65 subjects were in Malaria Ever Group and 61were in Malaria Never Group . There was no difference in lifestyle measures, hematological, and biochemical parameters. Mean G6PD levels were found similar in both the groups. Of 61 subjects in “malaria-never” group, 1 had deficient (1.1 unit/gm of Hb), 9 had low normal (between 2.5 and 10 units/gm of Hb), 48 had normal (10.1–20.5 units/gm of Hb), and 3 had higher than normal (>20.5 units/gm of Hb) G6PD levels. In comparison, 65 participants from “malaria ever” group, none was deficient, 6 had low normal, 58 had normal, and none had higher than normal G6PD levels. HPLC-based hemoglobin analysis showed significant higher number of participants in “malaria-never” group having altered hemoglobin. 12 participants had increased hemoglobin A2 levels, of which 10 were in “Malaria Occurrence Never” group; of them 6 could be diagnosed having hemoglobinopathy of specified variety. 3 of these 10 participants of “malaria-never” group had low G6PD levels also. Conclusion: Malaria Protection Hypothesis was not found to be true as per our findings, but there were subtle hints that G6PD protection with or without change in hemoglobin alteration maybe operable.

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“…Por ello, las mujeres en edad fértil que gestan con déficit vitamínico o depósitos insuficientes de hierro corporal tienen mayor riesgo de presentar anemia ferropénica durante el embarazo. Por tanto, la identificación oportuna de la anemia por deficiencia de hierro y el dosaje de ferritina son de vital importancia para un tratamiento óptimo y seguimiento antes de gestar y durante los controles prenatales (9) . La tasa promedio global de anemia durante la gestación en el mundo es 43% y, en América Latina y el Caribe, 37% en gestantes de 15 a 49 años (10) .…”

Section: Introductionunclassified

Resultados perinatales de la anemia en la gestación

Gonzales-Medina¹,

Arango-Ochante²

2019

Rev peru ginecol obstet.

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Uno de los aspectos esenciales en el manejo adecuado del control prenatal es la identificación de la anemia en la gestante. Se conoce las potenciales consecuencias de obviar la condición de anemia. Si se maneja dicha condición desde una perspectiva integral, los resultados adversos perinatales pueden ser reconocidos tempranamente y evitados. Estos incluyen la rotura prematura de membranas, el parto prematuro y la preeclampsia. Y en el recién nacido, el peso bajo al nacer, la asfixia perinatal y el síndrome de membrana hialina. Asimismo, en la infancia temprana ocurren alteraciones del neurodesarrollo, y la madre es susceptible de sufrir enfermedades crónicas.

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Low serum ferritin and G6PD deficiency as potential predictors of anaemia in pregnant women visiting Prime Care Hospital Enugu Nigeria

Cited by 8 publications

References 30 publications

Burden of disease and risk factors for mortality amongst hospitalized newborns in Nigeria and Kenya

Burden of disease and risk factors for mortality amongst hospitalized newborns in Nigeria and Kenya

Assessment of protective relationship of G6PD and other lifestyle factors with Malaria: A case-control study of medical professionals from a teaching medical institute, Gujarat

Resultados perinatales de la anemia en la gestación

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