Low serum copper and zinc concentrations in North Indian children with overweight and obesit

Abstract

Introduction: There are limited data on the alterations of serum copper and zinc, which have been proposed to have associations among children with obesity. Material and methods: A total of 173 children were enrolled and grouped into overweight/obese (n = 69) and non-obese (n = 104) according to CDC 2000 growth charts. Serum and whole blood zinc and copper concentrations were measured by validated ICP-MS method, and copper/zinc ratios were calculated and correlated to various anthropometric parameters. Results: Mean BMI in obese (24.78 ±3.93) was significantly higher as compared to non-obese (16.44 ±2.34; p < 0.0001, 95% CI: 15.9873-16.8998) children. Mean serum copper levels in obese children (1099.80 ±478.67 µg/l) were significantly lower than for non-obese children (2063.77 ±1006.81 µg/l; p = 0.0001, 95% CI: 1867.9755-2259.5755). Similarly, the mean serum zinc levels in obese children (851.53 ±406.33 µg/l) were also significantly lower as compared to non-obese children (1528.72 ±796.82 µg/l; p = 0.0001, 95% CI: 1373.76-1683.6879). Mean whole blood copper levels were significantly lower in obese (929.56 ±200.15 µg/l) as compared to non-obese (1393.22 ±861.92 µg/l; p = 0.0001, 95% CI: 1225.6023-1560.8481) children. Similarly, the mean whole blood zinc levels in obese (4384.11 ±881.87 µg/l) were also significantly lower as compared to non-obese (5380.14 ±2236.77 µg/l; p = 0.001, 95% CI: 4945.1491-5815.1416) children. Conclusions: The serum and whole blood concentrations of zinc and copper were found to be significantly lower in children with exogenous obesity as compared to controls. Additional investigations are recommended to see the underlying aspect of these elements in the development of obesity along with their co-morbidities.

Cross-sectional study protocol to assess the environmental exposure of endocrine disruptive chemicals: bisphenol-A and heavy metals in children

“…Agilent 7700x ICP-MS with collision cell technology will be used, which operates on Helium (He) collision mode, to remove all polyatomic interferences using a single set of conditions, giving lower levels of interference and better long-term stability. Whole blood and serum samples (200 µl) will be taken, followed by the addition of 2 mL of nitric acid, 0.5 ml of hydrogen peroxide, and 10 µl of gold solution (10 µg/l) in a microwave digestion tube [ 40 ].…”

The Association Between Antioxidant Status and Excess Weight in Children: A Systematic Review and Meta-analysis

“…Vivek et al showed that zinc and copper levels are significantly lower in obesity among Indian children aged 6-16 years [63]. In a study by Perrone et al serum zinc and copper levels were lower in obese, overweight children [24].…”

Hubungan Asupan Antioksidan Zinc Dengan Kejadian Kegemukan Pada Remaja Putri Di Kabupaten Majene

“…seng serta tembaga ditemukan secara signifikan lebih rendah pada anak-anak dengan obesitas eksogen dibandingkan dengan kelompok kontro 10. Adapun penelitian yang dilakukan di Kabupaten Majene menunjukkan bahwa 86,4% asupan zinc pada remaja obesitas tergolong kurang dari angka kecukupan gizi Distribusi Responden Berdasarkan Jumlah Siswi Setiap Kelas XII Siswi di SMA Negeri 1 Majene Tahun 2022 Berdasarkan hasil penelitian pada tabel 1 menunjukkan bahwa dari 148 sampel, distribusi responden berdasarkan kelas yang memiliki jumlah paling banyak yaitu kelas XII MIPA 1 sebanyak 25 siswi (16,9%), kelas XII MIPA 2 sebanyak 25 siswi (16,9%) dan kelas XII MIPA 4 sebanyak 25 siswi (16,9%).…”