Low serum cholesterol and suicide

Engelberg, Hyman

doi:10.1016/0140-6736(92)90609-7

Cited by 463 publications

(225 citation statements)

References 19 publications

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“…Although biological mechanisms of association between low cholesterol and suicidality have not been completely elucidated, reduced serum cholesterol level may be accompanied by changes in viscosity and function of serotonin receptors and transporters, as well as by decreased serotonin precursors (Engelberg, 1992). According to a frequently cited study by Engelberg (1992), low cholesterol level may be related to decreased lipid microviscosity in neural membranes and may reduce serotonin receptor exposure on the membrane surface, which leads to reduced function of serotonin receptors. The consequence of inhibited serotonin neurotransmission is lower inhibition of impulsive and aggressive behavior, which may trigger suicidal behavior.…”

Section: Resultsmentioning

confidence: 99%

Serum lipid levels and suicidality among male patients with schizoaffective disorder

Marčinko

Karlović

et al. 2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Section: Resultsmentioning

confidence: 99%

Serum lipid levels and suicidality among male patients with schizoaffective disorder

Marčinko

Karlović

et al. 2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…4 Lower cholesterol levels may weaken serotonergic functions and consequently trigger increased aggressive or auto-aggressive behavior. In addition, individuals with auto-aggressive behavior, manifested by self-mutilation or self-injury, have also been observed to have lower cholesterol levels in comparison with control subjects.…”

Section: Introductionmentioning

confidence: 99%

Intensity of pain and biochemical changes in blood plasma in spinal cord trauma

2009

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Study design: Cross-sectional, observational and longitudinal. Objectives: The aim of the study was to analyze the relationship between pain intensity, plasma lipids and severity of spinal cord injuries in patients with paraplegia (n ¼ 11), tetraplegia (n ¼ 16) and polytrauma (n ¼ 15). We concentrated on the hospitalization period immediately following injury. Methods: Pain intensity was assessed on a visual analog scale immediately after patients were transported to hospital, again 14 days after injury and before discharge from hospital. Blood samples were also obtained at these same times. We measured following biochemical parameters: total protein, albumin, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, glycemia, and C-reactive protein. Data were analyzed with respect to type of injury, state of unconsciousness immediately after injury, hemorrhage, measure of liability (self-inflicted injuries vs casualties), cause of the accident and pre-injury cholesterol levels. Results: On the day of injury, pain intensity correlated positively with HDL cholesterol (r ¼ 0.48, P ¼ 0.04); on the day of discharge from hospital, pain intensity correlated positively with blood glucose levels (r ¼ 0.67, P ¼ 0.0002). Diagnostic subgroups did not differ either in pain intensity or in pain dynamics during hospitalization. Total cholesterol level was lowest in patients with polytrauma. In all patients, the lowest total cholesterol level was observed immediately after injury. HDL cholesterol was highest after injury. Conclusion: After spinal cord injury, lower total cholesterol levels reflected more serious trauma intensity and HDL cholesterol predicted more intensive pain. Subjects responsible for their own injuries suffered less intensive pain than those who were not responsible for their injuries.

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“…Papakostas et al [84] suggest that low lipid levels are associated with decreased serotonergic function leading to depression and increased risk of suicide. Engelberg [85] hypothesised that decreased cholesterol levels can alter viscosity and functions of serotonin receptors and transporters. Some researchers have reported a positive correlation between total cholesterol levels and the level of cerebrospinal fluid (CSF) 5-Hydroxyindolacetic acid (5-HIAA) in suicide attempters [86,87].…”

Section: Affective Disordersmentioning

confidence: 99%

Application of fatty acid and lipid measurements in neuropsychiatry

Grela

Rachel

Cole

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Abstract:The importance of lipids in the understanding of disease states is constantly increasing. Whilst the link between metabolic disorders and lipids seems to be clear, interpreting lipid regulation in the context of neuropsychiatric disorders is a new approach. Mental disorders account for almost 15% of the total global disease burden with Alzheimer's disease, depression or schizophrenia being amongst the most widespread mental disorders in the general population. For this reason rapid and early diagnosis is crucial and finding the right biomarkers is of great importance. Lipids appear to be essential in learning the aetiopathology of neuropsychiatric diseases as well as in biomarker research as they are most abundantly present in the brain. This study discusses recent findings in neuropsychiatry in the context of lipid analysis.

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Low serum cholesterol and suicide

Cited by 463 publications

References 19 publications

Serum lipid levels and suicidality among male patients with schizoaffective disorder

Serum lipid levels and suicidality among male patients with schizoaffective disorder

Intensity of pain and biochemical changes in blood plasma in spinal cord trauma

Application of fatty acid and lipid measurements in neuropsychiatry

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