Low serum bilirubin concentration is associated with coronary artery calcification (CAC)

Tanaka, Muhei; Fukui, Michiaki; Tomiyasu, Ki-ichiro; Akabame, Satoshi; Nakano, Koji; Hasegawa, Goji; Oda, Y.; Nakamura, Naoto

doi:10.1016/j.atherosclerosis.2009.02.010

Cited by 66 publications

(45 citation statements)

References 27 publications

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“…6 Low TB level is associated with coronary artery calcification in Japanese subjects. 7 Gilbert syndrome, a genetic variant characterized by moderate hyperbilirubinemia attributable to reduced hepatic expression of the UDP-glucuronosyltransferase, which conjugates bilirubin, has been associated with a reduced risk for CVD. 8 In patients with cyanotic congenital heart disease, carotid IMT, and hence atherosclerosis disease risk, was decreased, which might be partly because of higher TB levels.…”

Section: Discussionmentioning

confidence: 99%

“…6 Low TB is associated with coronary artery calcification, which is a predictor of coronary artery events in Japanese people. 7 Gilbert syndrome, a genetic variant characterized by moderate hyperbilirubinemia, was reported to be associated with a reduced risk for CVD. 8 In subjects with Gilbert syndrome, elevated TB levels are associated with lower levels of advanced glycation endproducts that promote oxidant stress and inflammation.…”

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confidence: 99%

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Bilirubin Is Negatively Associated With Hemoglobin A1c Independently of Other Cardiovascular Risk Factors in Apparently Healthy Japanese Men and Women

Oda

Kawai

2011

Circ J

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Background: Serum total bilirubin (TB) is a potent antioxidant and may be a negative risk factor of cardiovascular disease. In non-diabetic adults, hemoglobin A1c (HbA1c), but not fasting plasma glucose, is an independent risk factor of cardiovascular disease. Methods and Results:Linear regression using TB as a dependent variable and cardiovascular risk factors, including HbA1c, as independent variables, linear regression using HbA1c as a dependent variable and other cardiovascular risk factors, including TB, as independent variables, and logistic regression using the highest decile (≥5.4%) of HbA1c as a dependent variable and TB and other cardiovascular risk factors as independent variables were performed for 893 apparently healthy male smokers, 1,607 male nonsmokers, and 1,680 women. The standardized regression coefficient of HbA1c for TB and that of TB for HbA1c was -0.12 (P=0.007) and -0.06 (P=0.02), respectively, in the smokers, -0.20 (P<0.0001) and -0.07 (P<0.0001), respectively, in the nonsmokers, and -0.21 (P< 0.0001) and -0.14 (P<0.0001), respectively, in the women. The odds ratio of 1 SD increment in TB for HbA1c ≥5.4% was not significant in the smokers, 0.67 (P=0.002) in the nonsmokers, and 0.55 (P<0.0001) in the women. Conclusions:Bilirubin was negatively associated with HbA1c independently of other cardiovascular risk factors in apparently healthy Japanese men and women. The association was weak in male smokers. (Circ J 2011; 75: 190 - 195 Bilirubin, A1c, and CVD Methods SubjectsBetween April 2008 and March 2010, 3,401 men and 2,095 women visited Medical Check-up Center, Tachikawa Medical Center, for general health screening. Among them 3,375 men and 2,069 women signed informed consent. Excluding subjects with a history of CVD or who were taking antidiabetic, antihypertensive, or antihyperlipidemic medication from those who gave consent, the resulting 2,500 men and 1,680 women comprised the subjects in the present study, which is part of the study on obesity-related cardiovascular risk factors at Tachikawa Medical Center. Data collected at the first visit were used for subjects who visited 2 or more times. The protocol for the study was approved by the ethics committee at Tachikawa Medical Center and written informed consent was given by each subject.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Bilirubin Is Negatively Associated With Hemoglobin A1c Independently of Other Cardiovascular Risk Factors in Apparently Healthy Japanese Men and Women

Oda

Kawai

2011

Circ J

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“…An increase in serum bilirubin of 1 mol/L led to a 14% decrease in odds for having a CAC score Ͼ400 after adjustment for several other major risk factors (15 ).…”

Section: Bilirubin Coronary Artery Disease and Coronary Artery Calcmentioning

confidence: 99%

“…In a recent cross-sectional study of 398 men and 239 women, serum bilirubin concentrations were found to be strongly related to coronary artery calcification (CAC) scores and independent determinants of CAC in both men and women (P Ͻ 0.0001) (15 ). An increase in serum bilirubin of 1 mol/L led to a 14% decrease in odds for having a CAC score Ͼ400 after adjustment for several other major risk factors (15 ).…”

Section: Bilirubin Coronary Artery Disease and Coronary Artery Calcmentioning

confidence: 99%

Serum Bilirubin and Genes Controlling Bilirubin Concentrations as Biomarkers for Cardiovascular Disease

2010

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BACKGROUND: Serum bilirubin has been consistently shown to be inversely related to cardiovascular disease (CVD). Recent studies showed serum bilirubin to be associated with CVD-related factors such as diabetes, metabolic syndrome, and body mass index. Although the association of serum bilirubin with CVD has been found in both retrospective and prospective studies, less information is available on the role of genes that control bilirubin concentrations and their association with CVD.CONTENT: In this review, we provide detailed information on the identity of the major genes that control bilirubin concentrations and their association with serum bilirubin concentrations and CVD risk. We also update the results of the major studies that have been performed on the association between serum bilirubin, CVD, and CVD-related diseases such as diabetes or metabolic syndrome. Studies consistently indicate that bilirubin concentrations are inversely associated with different types of CVD and CVD-related diseases. A conditional linkage study indicates that UGT1A1 is the major gene controlling serum bilirubin concentrations, and this finding has been confirmed in recent genomewide association studies. Studies also indicate that individuals homozygous for UGT1A1*28 have a significantly lower risk of developing CVD than carriers of the wildtype alleles.

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“…We began to research the causes of CHD by MSCT in April 2005 [9][10][11] . Additionally, we began to examine standard 75-g oral glucose tolerance tests (OGTT) in April 2006.…”

Section: Subjects and Study Designmentioning

confidence: 99%

U-Shaped Relationship between Insulin Level and Coronary Artery Calcification (CAC)

Tanaka

Fukui

Tomiyasu³

et al. 2010

JAT

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Aim: Recent studies have suggested that hyperinsulinemia is associated with high cardiovascular risk. The purpose of this study was to assess the relationship between the serum insulin level and coronary artery calcification (CAC). Methods: We performed a cross-sectional study of 582 consecutive and nondiabetic participants with clinical suspicion of coronary heart disease, and assessed the CAC score determined by multislice computed tomography. A standard 75-g oral glucose tolerance test was performed and venous blood was collected at 0, 30, 60 and 120 min for the measurement of plasma glucose and serum insulin.

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Low serum bilirubin concentration is associated with coronary artery calcification (CAC)

Cited by 66 publications

References 27 publications

Bilirubin Is Negatively Associated With Hemoglobin A1c Independently of Other Cardiovascular Risk Factors in Apparently Healthy Japanese Men and Women

Bilirubin Is Negatively Associated With Hemoglobin A1c Independently of Other Cardiovascular Risk Factors in Apparently Healthy Japanese Men and Women

Serum Bilirubin and Genes Controlling Bilirubin Concentrations as Biomarkers for Cardiovascular Disease

U-Shaped Relationship between Insulin Level and Coronary Artery Calcification (CAC)

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