Low Serum Amylase Levels in Drinking Alcoholics

Maruyama, Katsuya; Takahashi, Hirotaka; Okuyama, Keiji; Yokoyama, Akira; Nakamura, Yuji; Kobayashi, Yasunori; Ishii, Hiromasa

doi:10.1097/01.alc.0000078827.46112.76

Cited by 17 publications

(9 citation statements)

References 3 publications

(2 reference statements)

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“…This may be the most remarkable difference regarding alcohol consumption between serum amylase and HDL-C and adiponectin. Indeed, chronic mild to moderate alcohol consumption often injures and attenuates pancreatic functions [12,13], eventually resulting in chronic pancreatitis and reduced amylase secretion. In contrast, it has been reported that high alcohol consumption increases the risk of developing type 2 diabetes [14], which may be related to low serum amylase.…”

Section: Findings and Discussionmentioning

confidence: 99%

Revisiting the cardiometabolic relevance of serum amylase

Nakajima

Muneyuki

Munakata³

et al. 2011

BMC Res Notes

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BackgroundThe pancreas has dual functions as a digestive organ and as an endocrine organ, by secreting digestive enzymes and endocrine hormones. Some early studies have revealed that serum amylase levels are lower in individuals with chronic pancreatitis, severe long-term type 2 diabetes or type 1 diabetes. Regarding this issue, we recently reported that low serum amylase levels were associated with metabolic syndrome and diabetes in asymptomatic adults. In the light of this, we further investigated the fundamental relationship between serum amylase and cardiometabolic aspects by reanalyzing previous data which comprised subjects without diabetes treatment with oral hypoglycemic drugs or insulin (n = 2,344).FindingsSerum amylase was inversely correlated with body mass index independently of age. Higher serum amylase levels were noted in older subjects aged 55 years old or more (n = 1,114) than in younger subjects (P < 0.0001, ANOVA), probably due to lower kidney function. It was likely that serum amylase may act similarly to other cardiometabolic protective factors such as high-density lipoprotein cholesterol. However, serum amylase levels were significantly lower in drinkers, particularly daily drinkers (n = 746, P < 0.0001, ANOVA). Meanwhile, despite of consistent inverse relationship between serum amylase and fasting plasma glucose, the relationship between serum amylase and HbA1c may be rather complicated in individuals with normal or mildly impaired glucose metabolism (up to HbA1c 6.0% (NGSP)).ConclusionsRevisiting the cardiometabolic relevance of serum amylase may yield novel insight not only into glucose homeostasis and metabolic abnormalities related to obesity, but also possibly carbohydrate absorption in the gut.

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Section: Findings and Discussionmentioning

confidence: 99%

Revisiting the cardiometabolic relevance of serum amylase

Nakajima

Muneyuki

Munakata³

et al. 2011

BMC Res Notes

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“…In contrast, low serum amylase is thought to be due to diffuse pancreas destruction secondary to advanced chronic pancreatitis or alcoholic disease [7-9]. Low serum amylase is also associated with insulin deficiency in patients with type 1 diabetes and, less commonly, with type 2 diabetes [10-13], as well as the pathogenesis of insulin resistance in obese animal models [14,15].…”

Section: Introductionmentioning

confidence: 99%

Low serum amylase in association with metabolic syndrome and diabetes: A community-based study

Nakajima

Nemoto

Muneyuki

et al. 2011

Cardiovasc Diabetol

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BackgroundLow serum amylase levels may reflect impaired exocrine-endocrine relationship in the pancreas. However, few clinical studies have addressed this issue. Therefore, in this epidemiological study, we investigated whether low serum amylase was associated with the pathogenesis of impaired insulin action: metabolic syndrome (MetS) and diabetes.Research Design and MethodsSerum amylase, cardiometabolic risk factors, MetS (Adult Treatment Panel III criteria), and diabetes were examined in 2,425 asymptomatic subjects aged 30-80 years who underwent medical checkups recently (April 2009-March 2010) and 5 years ago.ResultsClinical variables, except for age and estimated glomerular filtration rate (eGFR), shifted favorably with increasing serum amylase levels. Plasma glucose levels at 1- and 2-hr during OGTT increased significantly with decreasing serum amylase levels. Multiple logistic analyses showed that, compared with highest quartile of serum amylase, lowest quartile was associated with increased risk for MetS and diabetes after adjustment for confounding factors [odds ratio (95% CI), 2.07 (1.39-3.07) and 2.76 (1.49-5.11), respectively]. In subjects who underwent checkups 5 years ago (n = 571), lower amylase at the previous checkup were associated with larger numbers of metabolic abnormalities at the recent checkup. The fluctuation over time in serum amylase levels in subjects with low serum amylase at the previous checkup was slight and was unaffected by kidney dysfunction.ConclusionsOur results indicate that low serum amylase is associated with increased risk of metabolic abnormalities, MetS and diabetes. These results suggest a pancreatic exocrine-endocrine relationship in certain clinical conditions.

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“…In alcoholics with pancreatic disorders, the serum amylase levels were higher than the normal levels, and they decreased after the alcohol abstinence [7]. In alcoholics without pancreatic disorders, the serum amylase levels were either low or normal, and they increased after the alcohol abstinence [7].…”

Section: Resultsmentioning

confidence: 89%

“…The use of saliva in the clinical diagnosis has distinct advantages such as the non-invasiveness of its collection, the non-necessity of skilled technicians for its collection and its suitability for repeated sampling Biochemistry Section [7]. Researchers have attempted to analyze the salivary chemical constituents in oral diseases, cancer, alcoholism, endocrine disorders and also in therapeutic drug monitoring [7]. There is a paucity of studies on the salivary biomarkers of alcoholism, and studies which have correlated the salivary changes with those of blood in alcoholics [5,8,9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Alcohol Withdrawl on Glutathione S-transferase, Total Antioxidant Capacity and Amylase in Blood and Saliva of Alcohol-Dependent Males

Peter¹

2013

JCDR

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Introduction: Alcohol biomarkers help in the early detection of alcoholism and its complications. There is a paucity of studies in India on the salivary markers of systemic diseases in general and on salivary alcohol biomarkers in particular.Objectives: The present study was aimed at assessing the effect of alcohol withdrawal on the antioxidants and amylase in blood and saliva, and at finding the correlation between the blood and the salivary parameters in alcoholics.Methods: Sixty alcohol-dependent males who were in the age group of 30 -70 years, who were admitted to the Deaddiction Centre for alcohol withdrawal treatment for one month, were the subjects of this study; age-matched healthy individuals were the controls. In the blood and saliva samples, the activities of Glutathione S-Transferase (GST) and amylase and the Total Antioxidant Capacity (TAC) were assayed. Results:The alcohol-dependent subjects showed significantly lower GST and amylase activities and the TAC in blood and saliva as compared to those in the controls (P<0.001). The alcohol withdrawal caused a significant increase in the GST and amylase activities and the TAC to near-control values. In the alcohol-dependent subjects, there was a significant correlation between the values in blood and saliva with respect to GST and TAC.

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Low Serum Amylase Levels in Drinking Alcoholics

Cited by 17 publications

References 3 publications

Revisiting the cardiometabolic relevance of serum amylase

Revisiting the cardiometabolic relevance of serum amylase

Low serum amylase in association with metabolic syndrome and diabetes: A community-based study

Effect of Alcohol Withdrawl on Glutathione S-transferase, Total Antioxidant Capacity and Amylase in Blood and Saliva of Alcohol-Dependent Males

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