Low Serum 25-Hydroxyvitamin D Level as a Potential Risk Factor of Erectile Dysfunction in Elderly Men with Moderate to Severe Lower Urinary Tract Symptoms

Kim, Hyung Suk; Cho, Min Chul

doi:10.5534/wjmh.200176

Cited by 5 publications

(7 citation statements)

References 28 publications

(67 reference statements)

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Section: Introductionmentioning

confidence: 85%

“…Many studies have shown a strong link between 25(OH)D and ED (Crafa et al, 2020; Horsanalı et al, 2020). Other studies have reported that 25(OH)D is also significantly lower in ED patients with diabetes and ED patients with lower urinary tract symptoms (Kim & Cho, 2022; Liu et al, 2022). Another study showed that serum L‐carnitine and 25(OH)D's were significantly reduced in ED patients who did not respond to oral sildenafil citrate (Mostafa et al, 2019).…”

Section: Introductionmentioning

confidence: 89%

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The relationship between serum 25‐hydroxy vitamin D and arteriogenic erectile dysfunction

Zhang

et al. 2022

Andrologia

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This study aimed to assess the relationship between 25(OH) levels and erectile dysfunction (ED), particularly arteriogenic ED (A‐ED). From September 2020 to January 2022, 150 patients diagnosed with ED by the International Index of Erectile Function‐5 (IIEF‐5) questionnaire were included. All patients were classified as organic ED and psychological ED by nocturnal penile tumescence and rigidity (NPTR) examination. Organic ED patients were divided into A‐ED and NA‐ED by penile doppler ultrasound (PDU) examination. Finally, 150 patients complaining of ED were enrolled in our study. 25(OH)D levels were significantly lower in patients with organic ED (18.24 ± 6.04 ng/ml) than in patients with psychogenic ED (20.90 ± 8.79 ng/ml) (p = 0.032). In A‐ED and NA‐ED, the mean of peak systolic flow velocity (PSV) values was 18.94 ± 5.28 cm/s and 51.57 ± 15.42 cm/s (p < 0.001), and the mean of 25(OH)D was 15.66 ± 5.86 ng/ml and 20.48 ± 5.90 ng/ml, respectively (p < 0.001). The results showed that 25(OH)D levels were positively correlated with IIEF‐5 scores and the PSV values in A‐ED patients. The 25(OH)D cut‐off value differentiating between A‐ED and NA‐ED was 15.05 ng/ml. Low 25(OH)D levels may be an independent risk factor for ED, especially A‐ED. ED patients should routinely undergo serum 25(OH)D level measurement, and 25(OH)D replacement therapy is necessary for patients with low vitamin D levels.

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Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 89%

The relationship between serum 25‐hydroxy vitamin D and arteriogenic erectile dysfunction

Zhang

et al. 2022

Andrologia

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“…The age dependence of hypovitaminosis D and ED seems to suggest a possible relationship between the two conditions. Consistent with this theory, it was observed that in patients older than 60 years with moderate to severe ED and lower urinary tract symptoms (LUTS), 25(OH)D levels and VDD were the independent risk factors for ED in the multivariate regression analysis, whereas these associations were not observed in analyses performed in other subgroups according to age and LUTS severity [ 14 ].…”

Section: Introductionmentioning

confidence: 92%

Mechanisms Suggesting a Relationship between Vitamin D and Erectile Dysfunction: An Overview

et al. 2023

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Vitamin D deficiency (VDD) and erectile dysfunction (ED) heavily burden the male population. The higher prevalence of both conditions in the elderly suggests a possible relationship between the two conditions. In addition, in vitro, animal, and human studies have revealed several mechanisms that may relate VDD to ED. The main mechanism by which vitamin D might exert its action on sexual function appears to be through the regulation of endothelial function. Indeed, VDD correlates with several markers of endothelial function. The action of vitamin D on the endothelium would be exercised both indirectly through its intervention in inflammatory processes and through the production of oxygen free radicals, and directly through the regulation of vascular stiffness, the production of nitric oxide, and the regulation of vessel permeability. Furthermore, the ubiquitous distribution of the vitamin D receptor in the human body means that this hormone can also exert a beneficial effect on erectile function by interfering with those comorbidities significantly associated with ED, such as hypertension, diabetes mellitus, hypercholesterolemia, chronic kidney disease, and hypogonadism. In this review, we thoroughly and carefully presented the evidence and mechanisms that would appear to relate vitamin D levels to erectile function. Furthermore, we have summarized the meta-analytic evidence for and against this association to provide a true representation of this topic. Data published to date suggest that low levels of vitamin D could contribute to worsening erectile function through several mechanisms. Therefore, vitamin D levels should be measured in patients with ED and maintained at adequate levels by specific supplementation in case of deficiency. However, the low quality and heterogeneity of clinical trials evaluating the effects of vitamin D administration on erectile function and ED-associated comorbidities do not allow for a univocal conclusion, and indicate the need for further studies to analyze these aspects.

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“…Add a data sharing statement to the paper Add the data sharing statement to the final proof of the edited paper (Fig. 5) [4].…”

Section: How To Deposit Data To the Harvard Dataverse Repositorymentioning

confidence: 99%

How to share data through Harvard Dataverse, a repository site: a case of the <i>World Journal of Men’s Health</i>

Park¹

2022

Sci Ed

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Data are a highly valuable asset for researchers. Earlier, researchers who conducted a study permanently owned their data. Currently, however, these data can be used as a source for performing further research. In 2018, the International Committee of Medical Journal Editors presented data sharing statements for clinical trials. Although this recommendation was limited to clinical trials published in medical journals, it is a meaningful change that formalized the concept of data sharing. However, the trend of data sharing is expected to spread beyond medical journals to include a wider range of scientific journals in the near future. Correspondingly, platforms that provide storage and services to share data will gradually diversify. The World Journal of Men’s Health has adopted a clinical data sharing policy. The data deposit process to Harvard Dataverse, a well-known data repository, is as follows: first, select the type of article for data sharing; second, create an account; third, write a letter to the corresponding author; fourth, receive and validate data from the authors; fifth, upload the data to Harvard Dataverse; and sixth, add a data sharing statement to the paper. It is recommended that scientific journal editors select an appropriate platform and participate in the new trend of data sharing.

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Low Serum 25-Hydroxyvitamin D Level as a Potential Risk Factor of Erectile Dysfunction in Elderly Men with Moderate to Severe Lower Urinary Tract Symptoms

Cited by 5 publications

References 28 publications

The relationship between serum 25‐hydroxy vitamin D and arteriogenic erectile dysfunction

The relationship between serum 25‐hydroxy vitamin D and arteriogenic erectile dysfunction

Mechanisms Suggesting a Relationship between Vitamin D and Erectile Dysfunction: An Overview

How to share data through Harvard Dataverse, a repository site: a case of the <i>World Journal of Men’s Health</i>

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