Low serum 25-hydroxyvitamin D level is associated with obesity and atherogenesis in adolescent boys

Naganuma, Junko; Koyama, Satomi; Arisaka, Osamu; Yoshihara, Shigemi

doi:10.6065/apem.2142112.056

Cited by 4 publications

(5 citation statements)

References 39 publications

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“…A population-based study conducted in Norway showed an inverse relationship between low serum 25(OH)D levels and increased BMI [90]. In various other studies, increased body fat and higher BMI are shown to be highly related to 25(OH)D levels [91][92][93][94]. Various meta-analyses have shown an inverse relationship between body weight and vitamin D levels; however, this relationship remains largely confusing due to confounding studies warranting more in-depth research studies to definitively prove the association [91].…”

Section: Other Micronutrientsmentioning

confidence: 96%

“…Various meta-analyses have shown an inverse relationship between body weight and vitamin D levels; however, this relationship remains largely confusing due to confounding studies warranting more in-depth research studies to definitively prove the association [ 91 ]. Most studies show that supplementation with vitamin D does not have an effect on body weight or BMI but does affect body fat distribution [ 92 , 93 ]. In a study on Japanese adolescents, it was shown that low serum vitamin D levels are associated with obesity and atherogenesis in adolescent boys only and not adolescent girls; hence future studies are warranted to establish a concrete relationship [ 92 ].…”

Section: Reviewmentioning

confidence: 99%

“…Most studies show that supplementation with vitamin D does not have an effect on body weight or BMI but does affect body fat distribution [ 92 , 93 ]. In a study on Japanese adolescents, it was shown that low serum vitamin D levels are associated with obesity and atherogenesis in adolescent boys only and not adolescent girls; hence future studies are warranted to establish a concrete relationship [ 92 ].…”

Section: Reviewmentioning

confidence: 99%

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Gut Microbiota Interventions for the Management of Obesity: A Literature Review

Gill¹,

Soni²,

Shringarpure³

et al. 2022

Cureus

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The gut microbiota (GM) has been recognized as an important factor in the development of metabolic diseases such as obesity; it has been reported that the composition of the GM differs in obese and lean subjects, suggesting that microbiota dysbiosis can contribute to changes in body weight. Dysbiosis occurs due to an imbalance in the composition of gut bacteria, changes in the metabolic process, or changes in the distribution of microbiota within the gut. Dysbiosis can change the functioning of the intestinal barrier and the gut-associated lymphoid tissues (GALT). Microbial manipulation may help with preventing or treating weight gain and associated comorbidities. Approaches to this may range from dietary manipulation, which is suitable to treat the individual’s microflora, to probiotics, prebiotics, synbiotics, and fecal microbiota transplant (FMT).

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Section: Other Micronutrientsmentioning

confidence: 96%

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

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Gut Microbiota Interventions for the Management of Obesity: A Literature Review

Gill¹,

Soni²,

Shringarpure³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“…Vitamin D deficiency in childhood and adolescence has been associated with multiple sclerosis (MS) and prediabetes, which are also linked to obesity [ 9 , 29 ]. Adolescent boys with low serum 25-hydroxyvitamin D levels were more likely to be obese and have an increased risk of atherogenic events [ 64 ]. The mechanisms underlying low levels of vitamin D are unclear.…”

Section: Skeletal Comorbiditiesmentioning

confidence: 99%

What is the disease burden from childhood and adolescent obesity?: a narrative review

Lee

2024

JYMS

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The prevalence of childhood and adolescent obesity has increased and exacerbated during the coronavirus disease 2019 pandemic, both in Korea and globally. Childhood and adolescent obesity poses significant risks for premature morbidity and mortality. The development of serious comorbidities depends not only on the duration of obesity but also on the age of onset. Obesity in children and adolescents affects almost all organ systems, including the endocrine, cardiovascular, gastrointestinal, reproductive, nervous, and immune systems. Obesity in children and adolescents affects growth, cognitive function, and psychosocial interactions during development, in addition to aggravating known adult comorbidities such as type 2 diabetes mellitus, hypertension, dyslipidemia, nonalcoholic fatty liver disease, obstructive sleep apnea, and cancer. Childhood and adolescent obesity are highly associated with increased cardiometabolic risk factors and prevalence of metabolic syndrome. The risk of cardiovascular and metabolic diseases in later life can be considerably decreased by even a small weight loss before the onset of puberty. Childhood and adolescent obesity is a disease that requires treatment and is associated with many comorbidities and disease burdens. Therefore, early detection and therapeutic intervention are crucial.

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“…The results of this study provide evidence that low serum 25(OH)D 3 levels are positively associated with the risk of obesity and atherogenesis in Japanese adolescent boys, but not in girls [ 11 ]. This sex difference was presumed to be related to body composition, sun exposure, puberty.…”

mentioning

confidence: 99%

Commentary on “Low serum 25-hydroxyvitamin D level is associated with obesity and atherogenesis in adolescent boys”

Lim

2022

Ann Pediatr Endocrinol Metab

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Low serum 25-hydroxyvitamin D level is associated with obesity and atherogenesis in adolescent boys

Abstract: Low serum 25-hydroxyvitamin D levels are associated with obesity and atherogenesis in adolescent boysRunning title: Low serum 25(OH)D and obesity and atherogenic risk in adolescents

Cited by 4 publications

References 39 publications

Gut Microbiota Interventions for the Management of Obesity: A Literature Review

Gut Microbiota Interventions for the Management of Obesity: A Literature Review

What is the disease burden from childhood and adolescent obesity?: a narrative review

Commentary on “Low serum 25-hydroxyvitamin D level is associated with obesity and atherogenesis in adolescent boys”

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