Low sensitivity of the comet assay to detect acetaldehyde-induced genotoxicity

Speit, Günter; Fröhler-Keller, Manuela; Schütz, Petra; Neuss, Simone

doi:10.1016/j.mrgentox.2008.07.010

Cited by 13 publications

(4 citation statements)

References 28 publications

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“…a strandbreaking effect) in acetaldehyde-treated isolated human lymphocytes under alkaline and neutral conditions. Theoretically, if cross-links and strand breaks are induced at the same time, reduced and increased DNA migration could cancel each other out, which results in a low sensitivity of CMT to detect acetaldehyde-induced genotoxicity (Speit, Fröhler-Keller, Schütz, & Neuss, 2008). Inflammation in the respiratory and olfactory system can be a possible non-genotoxic mechanism of acetaldehyde carcinogenicity (Woutersen, Appelman, Van, & Feron, 1986).…”

Section: Analysis Of Individual and Combinations Of Testsmentioning

confidence: 99%

Combinations of genotoxic tests for the evaluation of group 1 IARC carcinogens

Bhagat

2017

J of Applied Toxicology

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Section: Analysis Of Individual and Combinations Of Testsmentioning

confidence: 99%

Combinations of genotoxic tests for the evaluation of group 1 IARC carcinogens

Bhagat

2017

J of Applied Toxicology

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“…Posteriormente, Sako e col. (Sako et al, 2003;Sako et al, 2002) Kuykendall et al, 1992;Mao et al, 1999;Speit et al, 2008). Este mecanismo propõe, baseado em dados da literatura, que sistemas de reparo (incluindo NER e proteína de recombinação homóloga (Yang et al, 2002;Yang et al, 2001), troca de cromátides irmãs (Obe et al, 1987), aumento de polimerases como TLS (Minko et al, 2003) e aberrações cromossomais levam formação de câncer (Obe et al, 1979).…”

Section: Lesões Em Dna Promovidas Por Acetaldeídounclassified

“…O estabelecimento da concentração real de acetaldeído a que os fibroblastos foram expostos, medidas pela reação com DNPH, não foi avaliado em alguns trabalhos recentemente publicados (Duryee et al, 2008;Pereira et al, 2010;Speit et al, 2008).…”

Section: Efeito Citotóxico E Genotóxico Do Acetaldeído Em Fibroblastounclassified

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Quantificação de danos em DNA induzidos por acetaldeído. Potencial biomarcador de poluição ambiental

García¹

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À FAPESP pelo apoio financeiro e pela bolsa de doutorado. Ao CNPQ, Finep e INCT de processos redox em biomedicina-Redoxoma pelo apoio financeiro À Profa. Dra. Marisa H. G. Medeiros que me aceitou como aluna de iniciação científica quando eu mal sabia o que era DNA e me formou doutora, meu agradecimento e gratidão eternos. Ao Osmar F Gomes, pela amizade, companheirismo, paciência e colaboração de tantos anos. À Profa. Dra. Ana Paula de Melo Loureiro, uma das pessoas mais doces do mundo, que me ensinou desde as primeiras pipetadas até como se portar em um laboratório. À Dra. Sabrina de Almeida Marques, minha também orientadora de Iniciação Cientifica é uma das responsáveis por tudo que me tornei hoje, além de uma excelente amiga a qual sinto muita falta.

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Acetaldehyde as a Food Flavoring Substance: Aspects of Risk Assessment

Cartus,

Lachenmeier,

Guth

et al. 2023

Molecular Nutrition Food Res

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The Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG) has reviewed the currently available data in order to assess the health risks associated with the use of acetaldehyde as a flavoring substance in foods. Acetaldehyde is genotoxic in vitro. Following oral intake of ethanol or inhalation exposure to acetaldehyde, systemic genotoxic effects of acetaldehyde in vivo cannot be ruled out (induction of DNA adducts and micronuclei). At present, the key question of whether acetaldehyde is genotoxic and mutagenic in vivo after oral exposure cannot be answered conclusively. There is also insufficient data on human exposure. Consequently, it is currently not possible to reliably assess the health risk associated with the use of acetaldehyde as a flavoring substance. However, considering the genotoxic potential of acetaldehyde as well as numerous data gaps that need to be filled to allow a comprehensive risk assessment, the SKLM considers that the use of acetaldehyde as a flavoring may pose a safety concern. For reasons of precautionary consumer protection, the SKLM recommends that the scientific base for approval of the intentional addition of acetaldehyde to foods as a flavoring substance should be reassessed.

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Low sensitivity of the comet assay to detect acetaldehyde-induced genotoxicity

Cited by 13 publications

References 28 publications

Combinations of genotoxic tests for the evaluation of group 1 IARC carcinogens

Combinations of genotoxic tests for the evaluation of group 1 IARC carcinogens

Quantificação de danos em DNA induzidos por acetaldeído. Potencial biomarcador de poluição ambiental

Acetaldehyde as a Food Flavoring Substance: Aspects of Risk Assessment

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