Low Sensitivity of Simtomax Point of Care Test in Detection of Celiac Disease in a Prospective Multicenter Study

Tangermann, Paul; Branchi, Federica; Itzlinger, Alice; Aschenbeck, Jens; Schubert, Stefan; Maul, Jochen; Liceni, Thomas; Schröder, Andreas; Heller, Frank; Spitz, Wolfgang; Möhler, Ulrich; Graefe, U; Radkë, Michaël; Trenkel, Stefan; Schmitt, Markus; Loddenkemper, Christoph; Preiß, J; Ullrich, Reiner; Daum, S; Siegmund, Britta; Bojarski, Christian; Schümann, Michael

doi:10.1016/j.cgh.2018.09.032

Cited by 9 publications

(8 citation statements)

References 25 publications

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“…For optimal results as a screening tool, the POCT must have a high negative-predictive value in order to avoid missing cases. Literature analysis on POCT detecting anti-DGP IgA/IgG antibodies performed well in a population with high prevalence of CD [28], but showed a low sensitivity [29] in prospective studies. For this reason, the selection of a suitable POCT was a long and laborious procedure.…”

Section: Discussionmentioning

confidence: 99%

Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol

et al. 2022

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Coeliac disease (CD) is frequently underdiagnosed with a consequent heavy burden in terms of morbidity and health care costs. Diagnosis of CD is based on the evaluation of symptoms and anti-transglutaminase antibodies IgA (TGA-IgA) levels, with values above a tenfold increase being the basis of the biopsy-free diagnostic approach suggested by present guidelines. This study showcased the largest screening project for CD carried out to date in school children (n=20,000) aimed at assessing the diagnostic accuracy of minimally invasive finger prick point-of-care tests (POCT) which, combined with conventional celiac serology and the aid of an artificial intelligence-based system, may eliminate the need for intestinal biopsy. Moreover, this study delves deeper into the “coeliac iceberg” in an attempt to identify people with disorders who may benefit from a gluten-free diet, even in the absence of gastrointestinal symptoms, abnormal serology and histology. This was achieved by looking for TGA-IgA mucosal deposits in duodenal biopsy. This large European multidisciplinary health project paves the way to an improved quality of life for patients by reducing the costs for diagnosis due to delayed findings of CD and to offer business opportunities in terms of diagnostic tools and support.

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Section: Discussionmentioning

confidence: 99%

Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol

et al. 2022

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“…Using tests that can be completed in a nonclinical setting, patients with CD can self-monitor their gluten intake and report results to their clinicians, permitting diagnosis and alteration of treatment without any direct contact. However, further research is needed in the development of these tests; a study of 1,055 patients found that the sensitivity of the Simtomax point-of-care test for detecting CD was only 79% (48). Chronic liver disease.…”

Section: Telemedicine In the Management Of Chronic Diseasesmentioning

confidence: 99%

Current Applications of Telemedicine in Gastroenterology

et al. 2022

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Telemedicine generally refers to the use of technology to communicate with patients and provide health care from a distance. Advances in technology, specifically computers, cellphones, and other mobile devices, have facilitated healthcare providers' growing ability to virtually monitor and mentor patients. There has been a progressive expansion in the use of telemedicine in the field of gastroenterology (GI), which has been accelerated by the COVID-19 pandemic. In this review, we discuss telemedicine-its history, various forms, and limitations-and its current applications in GI. Specifically, we focus on telemedicine in GI practice in general and specific applications, including the management of inflammatory bowel disease, celiac disease, and colorectal cancer surveillance and its use as an aid in endoscopic procedures.

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“…Dieselbe Sensitivität erbrachte auch eine monozentrische, prospektive Studie mit 112 Patienten aus der Schweiz. Daher sollten aufgrund der unzureichenden diagnostischen Genauigkeit POCTs zum aktuellen Zeitpunkt nicht zur Diagnostik verwendet werden 19 .…”

Section: Diagnostik – Dos and Don’tsunclassified

Neues zur Zöliakie

Poralla¹,

Schümann²

2022

Dtsch Med Wochenschr

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Die Zöliakie ist eine T-Zell-vermittelte Autoimmunerkrankung. Da Gluten wie ein Trigger dieser Autoimmunreaktion fungiert, entstehen bei der Zöliakie Einblicke in die immunpathologischen Zusammenhänge, die die Entwicklung neuer Therapeutika ermöglichen. Dies und Zusammenfassungen relevanter Empfehlungen der in diesem Jahr erscheinenden, aktualisierten Zöliakie-Leitlinie sind Thema des folgenden Artikels.

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Low Sensitivity of Simtomax Point of Care Test in Detection of Celiac Disease in a Prospective Multicenter Study

Cited by 9 publications

References 25 publications

Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol

Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol

Current Applications of Telemedicine in Gastroenterology

Neues zur Zöliakie

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