Low response of granulomatous cheilitis to currently established treatments

Upadacitinib for Treatment of Granulomatous Cheilitis

“…Granulomatous cheilitis is an exclusion diagnosis, and most cases remain isolated; however, it can be associated with systemic diseases such as Crohn disease (CD), sarcoidosis, or Melkersson-Rosenthal syndrome. Current treatment primarily involves topical or intralesional corticosteroids, with severe cases often requiring systemic agents such as biologics, with variable outcomes and frequent relapses . The evidenced role of the Janus kinase–signal transducer and activator of transcription (JAK-STAT) pathway in granuloma formation has brought interest in using JAK inhibitors for granulomatous skin diseases; to our knowledge, their effectiveness in GC remains unexplored.…”