Low Relative Lean Mass is Associated with Increased Likelihood of Abdominal Aortic Calcification in Community-Dwelling Older Australians

Rodríguez, Alexander J.; Scott, David; Khan, Belal; Khan, Nayab; Hodge, Allison; English, Dallas R.; Giles, Graham G.; Ebeling, Peter R.

doi:10.1007/s00223-016-0157-z

Cited by 19 publications

(15 citation statements)

References 37 publications

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“…Higher muscle mass and not having sarcopenia was positively associated with serum albumin levels (149) better physical function (150–159), higher quality of life (157, 159), and longer survival (154, 160–162). Higher muscle mass was also negatively associated with cardiovascular disease risk factors (163), idiopathic pulmonary fibrosis (154), low bone mineral density (164), bone fractures (165), hospitalization (161), poor pulmonary function (166); sarcopenia was associated with poorer disease specific outcomes such as ankylosing spondylitis (164) and poor renal function (167). Better muscle attenuation was associated with improved balance (150), quality of life (159), and survival (168).…”

Section: Outpatient Settingsmentioning

confidence: 99%

Implications of low muscle mass across the continuum of care: a narrative review

et al. 2018

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Abnormalities in body composition can occur at any body weight. Low muscle mass is a predictor of poor morbidity and mortality and occurs in several populations. This narrative review provides an overview of the importance of low muscle mass on health outcomes for patients in inpatient, outpatient and long-term care clinical settings. A one-year glimpse at publications that showcases the rapidly growing research of body composition in clinical settings is included. Low muscle mass is associated with outcomes such as higher surgical and post-operative complications, longer length of hospital stay, lower physical function, poorer quality of life and shorter survival. As such, the potential clinical benefits of preventing and reversing this condition are likely to impact patient outcomes and resource utilization/health care costs. Clinically viable tools to measure body composition are needed for routine screening and intervention. Future research studies should elucidate the effectiveness of multimodal interventions to counteract low muscle mass for optimal patient outcomes across the healthcare continuum. Key messages Low muscle mass is associated with several negative outcomes across the healthcare continuum. Techniques to identify and counteract low muscle mass in clinical settings are needed.

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Section: Outpatient Settingsmentioning

confidence: 99%

Implications of low muscle mass across the continuum of care: a narrative review

et al. 2018

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“…In the current study, low BMI was associated with BMD <70%. Reginster et al reviewed the link between osteoporosis and sarcopenia [ 19 ], and age-related loss of skeletal muscle was associated with cardiovascular mortality in another study [ 20 ]. Treatment to increase muscle volume in addition to BMD may help decrease surgical invasiveness and patients' subsequent healthy life expectancy.…”

Section: Discussionmentioning

confidence: 99%

Association of Postoperative Neutrophil Lymphocyte Ratio (NLR) and Monocyte Lymphocyte Ratio (MLR) with the Presence of Osteoporosis in Japanese Patients after Hip Fracture Surgery: A Retrospective Cohort Study

Bekki

Arizono

Hama

et al. 2021

Journal of Osteoporosis

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Background. The diagnosis of osteoporosis is based on bone mineral density measurements expressed as a percentage of the young adult mean (YAM) in Japan. Osteoporosis is defined as YAM <70%, and intervention is recommended at this cutoff. Because osteoporosis has a strong association with systemic metabolic disorders, we postulated that patients with YAM <70% had higher inflammatory biomarker concentrations owing to the higher systemic stress compared with YAM >70%. Method. We retrospectively reviewed 94 patients with low-trauma hip fractures. Blood examinations were performed on postoperative day (POD) 1 and POD 7. We used neutrophil lymphocyte ratio (NLR) and monocyte lymphocyte ratio (MLR) to evaluate postoperative recovery. After dividing the 94 patients into two groups according to a YAM cutoff of 70%, we compared the differences in NLR and MLR. Results. On POD 1, patients with YAM >70% had a median NLR of 5.7 and a median MLR of 0.66, which were significantly lower than for patients with YAM <70% (8.8 and 0.9, respectively). Similarly, on POD 7, patients with YAM >70% had a median NLR of 2.0 and a median MLR of 0.31, which were significantly lower than for patients with YAM <70% (3.5 and 0.43, respectively). Conclusion. A YAM cutoff of 70% is an appropriate intervention threshold regarding postoperative recovery after hip fracture surgery. Mini-Abstract. Patients with YAM >70% showed lower NLR and MLR on POD 1 and POD 7. A YAM cuffoff of 70% is an appropriate intervention threshold regarding postoperative recovery after hip fracture surgery.

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“…However, Aortic Arch Tail Sign in patients without hip fractures did not make a big impact compared to patients with hip fractures. This outcome may be because hip fracture would be strongly correlated with not only low BMD but also the low relative muscle mass [ 16 ]. A recent study showed the outcome that severe abdominal aortic calcification was significantly related with hip fracture, but not with vertebral or nonvertebral fractures [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Ascending Aortic Calcification as a Potential Predictor for Low Bone Mineral Density: A Pilot Study

Bekki

Arizono

Suzuki

et al. 2021

Journal of Osteoporosis

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Background. Identifying the factors related to low bone mineral density (BMD) can have significant implications for preventing hip fractures. The correlation between ascending aortic calcification and BMD has never been reported. Therefore, the purpose of the current study is to confirm the hypothesis that ascending aortic calcification can be used as a predictive factor for low BMD and to find a radiographic sign to show it. Method. Plain film and computed tomography (CT) images of the thorax were obtained from 91 patients with hip fractures. Using the images, the calcification line of the ascending aorta adjacent to the aortic arch was evaluated. A prominent calcification line confirmed by both plain film and CT was classified as +2. A line which was ambiguous on plain film but confirmed by CT was classified as +1. Cases with no calcification were categorized as 0 (control). We compared the classified score with the BMD and calculated the kappa coefficient to measure intraobserver reliabilities for this radiographic finding. Results. Twenty-eight patients showed a +2 line, twenty-four patients showed a +1 line, and thirty-nine patients showed 0 lines. The median BMD of each group was 0.37 for the +2 line, 0.45 for the +1 line, and 0.51 for the 0 line. The BMD for the +2 group was significantly lower than the others. The kappa coefficient was approximately 0.6 ( p < 0.01 ). Conclusion. The imaging finding of calcification of the ascending aorta might be considered as a potential surrogate marker of low BMD. In such subjects, BMD might be ordered for the confirmation of diagnosis of osteoporosis. Mini-Abstract. The Aortic Arch Tail Sign, a calcification line on the ascending aorta, was relevant to low BMD in the current study. BMD can be ordered for the confirmation of diagnosis of osteoporosis in a subject incidentally found to have ascending aorta calcification on X-ray or CT.

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Low Relative Lean Mass is Associated with Increased Likelihood of Abdominal Aortic Calcification in Community-Dwelling Older Australians

Cited by 19 publications

References 37 publications

Implications of low muscle mass across the continuum of care: a narrative review

Implications of low muscle mass across the continuum of care: a narrative review

Association of Postoperative Neutrophil Lymphocyte Ratio (NLR) and Monocyte Lymphocyte Ratio (MLR) with the Presence of Osteoporosis in Japanese Patients after Hip Fracture Surgery: A Retrospective Cohort Study

Ascending Aortic Calcification as a Potential Predictor for Low Bone Mineral Density: A Pilot Study

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